25 Heart Vasculature Coupling

Question 1

What will contractility changes do to a cardiac function curve?

Answer 1

-Shift up or down with a “widening” of the shift as well

Question 2

What will afterload changes do to a cardiac function curve?

Answer 2

-Shift up or down

Question 3

What are the 2 variables in a cardiac function curve?

Answer 3

• Stroke Volume (or cardiac output)

- RAP (a.k.a. preload)

Question 4

What effect on distribution of blood in the vessels will an increase in cardiac output have?

Answer 4

Translocate blood from venous to arterial side

Question 5

What effect will increased blood volume have on a reversed cardiac function curve?

Answer 5

None, but the vascular function curve will shift up and right on its slope

Question 6

What effect will increased venous compliance have on a reversed cardiac function curve?

Answer 6

Shift down and left

Question 7

What effect will increased TPVR have on a reversed vascular function curve?

Answer 7

Down and left (with a “widening” on the left side)

Question 8

Renin, Ang 2, Aldosterone all have what effect on BP?

Answer 8

• Increase

- Ang 2 also increases SNA, thirst, and sodium appetite by binding AT1R’s

Question 9

What effect will Ang 1-7 have on BP?

Answer 9

-Decrease by binding to Mas receptor, antagonizing AT1R (the Ang 2 receptor)

Question 10

Why is Atrial Natriuretic Peptide released, and what effect will it have?

Answer 10

• In response to atrial distension

- Vasodilation, sodium excretion (inhibit resorption)