2.5 Biological Membranes Flashcards
What is the role of membranes?
- Provides a partially permeable barrier
- Compartmentalisation
- Antigens to recognise cells as ‘self’
- Enzymes in metabolic pathways
- Releases chemicals for cell signalling
- Receptors for chemical signals for other cells
What are functions of internal membranes?
- Partially permeable membrane
- Compartmentalisation - localising regions in an organelle
- enclose enzymes e.g. in lysosomes
- transports substances in vesicles
What is the fluid mosaic model?
explains how biological molecules are arranged to form cell membranes
What are the features of the fluid mosaic model?
Phospholipids
Cholesterol
Glycoproteins and glycolipids
Transport proteins
Why are membranes described as ‘fluid’?
- phospholipids and proteins can move around via diffusion
- The phospholipids mainly move sideways, within their own layers
- The many different types of proteins interspersed throughout the bilayer move about within it (a bit like icebergs in the sea) although some may be fixed in position
What are phospholipids?
- Forms the basis of the membrane
- tails form a hydrophobic core and heads form the hydrophilic outer layer
How does the phospholipid bilayer act as a barrier?
it acts as a barrier to most water-soluble substances (the non-polar fatty acid tails prevent polar molecules or ions from passing across the membrane)
What is the role of cholesterol?
- It binds to the hydrophobic tails of the bilayer
- Cholesterol increases the fluidity of the membrane, stopping it from becoming too rigid at low temperatures - Interaction between cholesterol and phospholipid tails also stabilises the cell membrane at higher temperatures by stopping the membrane from becoming too fluid
- Increases strength and stability
What is the role of glycolipids and glycoproteins?
- Both contains extrinsic carbohydrate chains - acts as receptor molecules
What are the types of receptor?
- Signalling receptors for hormones and neurotransmitters
- Cell to cell recognition e.g. antigens
- Cell adhesion and stabilisation
- Receptors in endocytosis
What are the roles of proteins in the membrane?
Transport proteins create hydrophilic channels to allow ions and polar molecules to travel through the membrane
1. Carrier proteins
2. Channel proteins
What is the effect of temperature below 0 on membranes?
- Phospholipids have no energy so cannot move
- Rigid membrane structure
- Phospholipids packed closely together
- Channel and carrier proteins denature
What is the effect of temperature from 0 - 45 on membranes?
- Phospholipids can move around - membrane is partially permeable
- Increasing temp gives molecules more kinetic energy - means they more more making the membrane more ‘leaky’ and permeable
What is the effect of temperature from 45 + on membranes?
- Phospholipids break down and membrane becomes more permeable
- Channel and carrier proteins denature so cannot control what enters or leaves the cell - increased permeability of the membrane
How does solvent concentration affect the membrane?
Organic solvents can increase cell membrane permeability as they dissolve the lipids in the membrane, causing the membrane to lose its structure