24 - Infections

Question 1

astrocytes: what protein

Answer 1

glial fibrillary acidic protein GFAP

Question 2

most abundant cell type in CNS?

Answer 2

astrocytes

Question 3

types of astrocytes

Answer 3

Type I, Type II, fibrillary, protoplasmic, radial

Question 4

astrocytes major functions (4)

Answer 4

biochemical support of endothelia cells that form BBB, provide nutrients to nervous tissue, maintain extracellular ion balance, role in repair/scarring process after injury

Question 5

oligodendrocytes: what %? dervied from? what are they?

Answer 5

5 - 10 % of all CNS cells. neuroectoderm. myelin producing cells that provide structural support for axons satellite cells

Question 6

major functions of astrocytes (2)

Answer 6

produce myelin = increase axonal transmission speed, reduce axonal capacitance during saltatory propagation

Question 7

oligodendrocytes: prototype expressed proteins (3)

Answer 7

myelin basic protein MBP. proteolipid protein PLP. 2’3’ cyclic nucleotide 3’ phosphodiesterase CNPase

Question 8

microglia: what %? derived from?

Answer 8

~10% of all CNS cells. from yolk sac, but also from infiltrating blood macrophages and monocytes.

Question 9

major functions of microglia (2)

Answer 9

sentinel sensors of CNS, recognize + respond to potentially damaging stimuli (like injuries or infections)

Question 10

what do microglia do (2)

Answer 10

phagocytose damaged cells, infectious agents, blood. produce inflammatory molecules.

Question 11

3 prototype expressed proteins for microglia

Answer 11

MHC Class II, Iba-1, CD68

Question 12

microglia: part of what immune system?

Answer 12

innate (first line non specific, rather than the adaptive)