24 Feb Nutrition Flashcards
B12 def due to omeprazole use
B12 is ingested bound to animal protein and must be liberated in the stomach by PEPSIN.
Pepsin is activated from pepsinogen by Gastric Acid.
Pts in long term PPI develop b12 def due to achlorhydria.
Dx : B12 levels
If inconclusive:
Methylmalonic acid levels
Homocyteine levels
First sign of B12 def
Symmetric Lower extremity paresthesia due to myelinated peripheral nerve damage.
Alarm signs for pathologic constipation
Delayed passage of meconium
Fever/vomiting
Ribbon stools
Poor growth
Severe abd distension
Constipation around 6months and ttt
Functional constipation due to dietary change(weaning) solid foods with low fibre and decreased fluid content.
Exam :
unremarkable with normal growth
(Maybe some abd distension , LLQ firmness or palpable stool)
Ttt:
🥾Dietary change with non digestible osmotically active carbs -sorbitol , Apple prune pear juice/puree
🥾polyethylene glycol (refractory)
Indication forBariatric surgery
BMI >- 35
BMI > - 30 with T2DM
BMI >- 30 with failure to lose weight or uncontrolled comorbidities
Options for pts unable to lose weight through lifestyle modification.
Weight loss medications :
🥁Pts who are overweight (BMi 25-29.9) With comorbidities
🚜Orlistat , semaglutide , tirzepatide
👠Naltrexone/bupropion, phentermine, topiramate.
Bariatric surgery :
🚨BMi >- 35 or BMI >-30 with DM and comorbidities.
🚨Medication failure not a criteria req for surgery
🚨Wt loss medication plus Surgery can also b pursued.
Pathogenesis and cause of Dumping Syndrome
Destruction or bypass of pyloric sphincter
Rapid emptying of hypertonic gastric contents.
Cause :
➡️Esophageal /Gastric resection or Reconstruction
➡️Vagal Nerve injury (Nissen fundoplication)
S/S of dumping syndrome
👐15-30 min after meals
👐Abd pain , diarrhea , nausea
👐Hypotension /Tachycardia
👐Dizziness /confusion , Fatigue , diaphoresis
Ttt of dumping Syndrome
Clinical dx
Dietary modification is best ttt.
Small freq meals
Replacement of simple sugars with complex carbs
Incorporation of high fibre and protein rich foods
Symptoms diminish over time
Minority of pts benefit from a trial of octreotide or reconstructive surgery.
How to identify dumping syndrome ina scenario
Post gastrectomy pt with GI symptoms nausea diarrhea abd cramps and vasomotor S/S : palpitations , diaphoresis
2 types if Dysphagia
🦵🏾Oropharyngeal :
Food stuck in throat , nasal regurg , coughing , choking
🦵🏾Esophageal dysphagia :
Food stuck in chest
Common cause Of oropharyngeal Dysphagia
Stroke
Advanced dementia
Oropharyngeal malignancy
Neuromuscular dx ( Myasthenia)
How to evaluate Dysphagia
💩Diff initiating swallow
Coughing, choking, nasal regurg (oropharyngeal)
⬇️
Do VideoFluoroscopic barium swallow
💩Diff with food passing thru esophagus
Food gets stuck in Chest (esophageal)
↪️If dysphagia with solids and liquids at onset (achalasia ).
⬇️
Do Barium swallow and then manometry with endoscopy
↪️If dysphagia of solids progressing to liquids (malignancy)
⬇️
Do Upper GI endoscopy (with/wo Barium swallow beforehand)
Cause of blood streaked stool in a well appearing child of age <6mo
FPIAP (If stools are loose with mucus)
Anal fissure (if constipated)
DD meckel diverticulum. Rarely presents before 6mo. And chikdren are mostly ill appearing.
Chemotherapy induced diarrhea
Secretory (Nocturnal diarrhea)
Watery voluminous and persistent despite periods of fasting.
Ttt: Oral hydration
Loperamide
Workup fro chemo induced diarrhea
CBC , serum chemistry
Stool for CDI , fecal occult.
Postbariatric anastomotic leak CF
Happens due to breakdown of either gastronejunal or jejunojenunal anastomosis
CF:
Usually in the first week post op
Fever
Abd pain
Tachypnea
Tachycardia
HR >120/min (most sensitive predictor)
Dx of anstomotic leak
Dx
Oral contrast enhanced Abd CT scan
Upper GI series
Ttt:
Urgent surgical repair
Esophagoduodenoscopy is Contraindicated as it can worsen the leak and cause perforation.
SIBO risk factors
➗anatomic abnormalities (strictures , surgery , Small bowel diverticulosis)
➗motility disorders (diabetes, scleroderm, opioid use)
➗immunodef (IgA def)
➗chronic Pancreatitis
➗gastric hypochlorhydria , PPI use
Mechanism of SIBO
The prox small intestine contains minimal bacteria colonization due to Gastric Acidity and peristalsis.
In roux en Y Gastric bypass , a blind loop of intestine allows for excessive bacterial growth.
Condition that alter motility(Systemic Sclerosis , DM) , anatomy (strictures) , Gastric / Pancreatic secretions (atrophic Gastritis , chronic Pancreatitis ) predispose to SIBO.
Nutritional Deficiencies of SIBO
Nutritional def ;
B12 , fat soluble vitamin def
Macrocytic anemia
Folic acid and vit K maybe elevated due to inc production from enteric bacteria.
Test to confirm SIBo
Lactulose and glucose breath test( that measures the production of Hydrogen and methane by intestinal flora )
Gold standard:
Endoscopy with jejunal aspirate and culture shows inc bacterial burden (>103 colony forming units)
Ttt of SIBO
Empiric Ab (rifaximin)
CI to breast feeding
⚫️Galactosemia in newborn
⚫️Maternal HIV infection in dev countries where formula is available
⚫️Herpetic breast lesions , active varicella
⚫️Most chemo and radio ttt
⚫️Active TB until no longer contagious (2w of anti TB ttt)
⚫️Active substance use dx without enrollment in a methadone or buprenorphine ttt program
Conc of methadone in Breast milk are low and BF is encouraged regardless of prescribed dose
Newborns of mothers taking methadone during pregnancy are at inc risk for Neonatal abstinence syndrome (withdrawal from in utero exposure to opioids)