24: Extrinsic regulation of arterial pressure, long term

Question 1

What are the mechanisms for renin release

Answer 1

Renal baro-receptors
Decreases in salt in tubule cells (macula densa)
Sympathetic stimulation

Question 2

How do baro-receptors release renin

Answer 2

Sense change in glomerular arterial pressure

Decreased pressure on juxtaglomerular cells trigger renin release

Question 3

What does Renin release trigger

Answer 3

angiotensin 2 production

Question 4

What does Angiotensin 2 trigger

Answer 4

aldosterone and ADH release

Question 5

Speed of aldosterone’s actions

Answer 5

slow

Question 6

Increased stimulation of RAAS

Answer 6

Increased: 
TPR
Na retention
Water retention
Blood pressure

Question 7

ADH

Answer 7

acts on renal collecting duct to increase water absorption

Question 8

When are vasopressin levels high

Answer 8

Dehydration and hemorrhage

Question 9

What is atrial natriuretic peptide (ANP)

Answer 9

peptide released during excessive stretch

Increase diuresis and natiuresis

Question 10

What is the primary trigger for ANP release

Answer 10

hypervolemia

Question 11

ANP action on vasculature

Answer 11

Vasodilator

Question 12

ANP direct effects

Answer 12

inhibit aldosterone
Inhibit collecting duct Na reabsorption
Increased filtration pressure