23 - Thermoregulation Flashcards
body temperature is ___ but not? what is important
regulated, but not invariant: when you measure is important
body tempr is regulated about __? using? system involves?
set point, using feedback control mechanisms. regulated system that involves sensors, controller/comparator and effectors
first line of defense?
peripheral sensation
cells that respond to temp found where? what area is the control area? and why?
throughout the neruoaxis. hypothalamus: ideally positioned to monitor deep body temperature
NTs and body temp? also affects? drugs?
nearly every NT affects body temp if introduced into hypothalamus. nearly every transmitter that affects body temp also affects food intake/energy expenditure. drugs interact with NTS - can affect temp
effect of ecstacy? other drugs?
causes hyperthermia in warm enviornments. alcohol = hypothermia
2 main goals of thermoregulatory effectors
maximise or minimize heat exchange with environment. alter heat production
what control for fine tuning?
vasomotor control = fine tuning of thermoregulatory heat loss
only means of eliminating excess body heat?
sweating: only way when ambient temperature > core temperature
muscles and heat?
important source of metabolic heat + are recruited for thermoregulatory function during shivering. skeletal/motor NS recruited for autonomic function
non shivering thermogenesis: occurs when? can be ramped up by?
by product/inefficiency of cellular metabolism. sympathetic NS (NA and adrenaline) hormones (thyroid), diet
brown fat: role? obesity research
neonates: important source of metabolic heat. goal: turn WAT into BAT
what is fever
change in set point; neuroimmune respose
feber: generated in? requires? activate?
periphery, requires signalling to brain. activation of immune cells aka microglia in CNS
NSAIDs
antipyretics, inhibit prostaglandin synthesis
responses to LPS (5)
feber, increased sleep, anorexia, sickness behaviour, hyperalgesia
concl: body temp regulated? changes?
body temp regulated around a set point, set point can change (circadian, monthly, infection, etc)
concl: system has? control? what interferes?
system has afferents = thermoreceptors in skin, deep body + brain. hypothalamus = major control area. drugs can interfere
