21/22 - Appetite II

Question 1

POMC expression elevated with? knock out mice?

Answer 1

expression elevated with satiety. MC4-R (aMSH receptor) knockout mice = obese

Question 2

a MSH: inhibits? alters?

Answer 2

inhibits NPY release. alters metabolism to increase energy expenditure

Question 3

ACRP: name? normally expressed?

Answer 3

agouti protein: normally expressed in periphery, but can be expressed ectopically

Question 4

AGRP: action on receptors?

Answer 4

blocks melanocortin MC3, 4 receptors

Question 5

hypothesis for NPY?

Answer 5

affects synpatic inputs to parvocellular neurons of PVN

Question 6

NPY: inhibits what current?

Answer 6

inhibts IPSC in = more excitable

Question 7

melanocortin 4 agonist: effect?

Answer 7

increases NPY inhibited IPSC. wrks only on the GABA system.

Question 8

aMSH and AgRP on IPSC?

Answer 8

aMSH increases IPSC amplitude. AgRP blocks this action

Question 9

CART: effect when injected? costored?

Answer 9

causes weight loss. costored in POMC neurons

Question 10

MCH: effect when injected? knockout?

Answer 10

causes eating when injected. knockout: becomes lean

Question 11

MCH: found where? colocalized?

Answer 11

LH, projects to DMH, VMH. colocalized with CART

Question 12

orexin: injection causes? knock out causes?

Answer 12

eating when injected. knockout becomes lean

Question 13

ORX-1R knock out?

Answer 13

narcolepsy

Question 14

CCK: what and from where? receptors where? but?

Answer 14

peripheral signals from duodenum. CCK B receptors in brain by CCK doesn’t cross BBB

Question 15

orixigenic and anorexigenic peptides

Answer 15

orexigenic/stimulate appetite = NPY, ACRP, MCH, orexin. anorexic: aMSH, CART