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MSRA Dermatology [3] > [23] Skin Manifestations of Systemic Diseases > Flashcards

[23] Skin Manifestations of Systemic Diseases Flashcards

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Dermatology Board Prep flashcards
1
Q

How does erythema nodosum present?

A

Painful blue-red lesions on anterior shins

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2
Q

What conditions can cause erythema nodosum?

A 
Sarcoid
Strep infections
IBD
TB
Behcet's
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3
Q

What drugs can cause erythema nodosum?

A

Sulfonamides

OCP

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4
Q

How does erythema multiforme present?

A

Symmetrical traget lesions on palms, soles, and limbs

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5
Q

What is the presentation of erythema multiforme possibly mediated by?

A

IgM deposition

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6
Q

What is erythema multiforme usually secondary to?

A

Infection

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7
Q

What infections can cause erythema multiforme?

A

HSV

Mycoplasma

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8
Q

What drugs can cause erythema multiforme?

A 
Sulphonamides
NSAIDs
Penicillins
Nitrofurantoin
Phenothiazines
Anti-convulsants
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9
Q

What are Stevens-Johnson syndrome and TEN (toxic epidermal necrosis)?

A

Severe variants of erythema multiforme

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10
Q

What causes Stevens-Johnson syndrome and TEN?

A

Nearly always drug induced

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11
Q

How do Stevens-Johnsons syndrome and TEN present?

A

Fever

Mucosal and skin ulceration and necrosis

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12
Q

How does pyoderma gangrenosum present?

A

Wide (10cm), deep ulceration with violent border, undermined edge, and purulent surface

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13
Q

Where does pyoderma gangrenosum commonly occur?

A

On legs

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14
Q

How does pyoderma gangrenosum appear once its healed?

A

Cribiform (pitted) scars

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15
Q

What conditions is pyoderma grangrenosum associated with?

A 
IBD
Autoimmune hepatitis 
Wegener's 
RA
Leukaemia
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16
Q

How is pyoderma gangrenosum managed?

A

High-dose systemic steroids

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17
Q

How does vitiligo present?

A

Chalky white patches with hyperpigmented borders

18
Q

What happens to vitiligo in sunlight?

A

Itches

19
Q

What is vitiligo associated with?

A

Autoimmune disorders

20
Q

How does livedo reticularis present?

A

Persistent mottled red/blue lesions that don’t blanch

21
Q

Where is livedo reticularis commonly found?

A

Legs

22
Q

What triggers livedo reticularis?

A

Cold

23
Q

What are the causes of livedo reticularis?

A

Idiopathic
Vasculitis
Obstruction
Sneddon’s syndrome

24
Q

What kinds of vasculitis can cause livedo reticularis?

A

RA
SLE
Polyarteritis nodosum

25
Q

What are the obstructive causes of livedo reticularis?

A

Anti-phospholipid syndrome

Cryoglobulinaemia

26
Q

What does Sneddon’s syndrome consist of?

A

Livedo reticularis and CVAs

27
Q

What are the skin manifestations of rheumatic fever?

A

Erythema marginatum

28
Q

What are the skin manifestations of lyme?

A

Erythema chonicum migrans

29
Q

What are the skin manifestations of dermatomyositis?

A 
Heliotrope rash on eyelids
Macular rash
Gottron's papules 
Mechanic's hands
Nailfold erythema and telangiectasis
30
Q

What are the skin manifestations of diabetes mellitus?

A 
Ulcers
Candida
Kyrle disease
Acanthosis nigricans
Necrobiosis lipoidica on shins
Granuloma annulare on hands and feet
31
Q

What are the skin manifestations of sarcoidosis?

A 
Erythema nodosum
Erythema multiforme
Lupus pernio
Hypopigmented areas
Red/violet plaques
32
Q

What are the skin manifestations of coeliac disease?

A

Dermatitis herpetiformis on elbows

33
Q

What are the skin manifestations of grave’s disease?

A

Pre-tibial myxodema on lateral malleolus

34
Q

What are the skin manifestations of RA?

A

Rheumatoid nodules

Vasculitis appearing as palpable purpura

35
Q

What are the skin manifestations of SLE?

A

Facial butterfly rash

36
Q

What are the skin manifestations of systemic sclerosis?

A 
Calcinosis
Raynaud's 
Sclerodactyly
Telangiectasia
Generalised skin thickening
37
Q

What are the skin manifestations of liver disease?

A 
Palmar erythema
Spider naevi
Gynaecomastia
Decreased secondary sexual hair 
Jaundice
Bruising
Excoriations
38
Q

What are the skin manifestations of end-stage renal disease?

A

Pruritis
Xerosis
Pigment change
Bullous disease

39
Q

What additional skin manifestations may be present with end-stage renal disease?

A

Manifestations associated with cause, or associated with transplant

40
Q

What skin manifestations may be associated with transplant in end-stage renal disease?

A

Cushingoid appearance
Gingival hyperplasia
Infections
BCC, SCC, or melanoma

41
Q

What are the skin manifestations of neoplasia?

A

Acanthosis nigricans
Dermatomyositis
Thrombophlebitis migrans
Acquired ichthyosis

MSRA Dermatology [3] (26 decks)

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