23 - RTKs in Cancer Flashcards
What can multiple RTK inputs cause?
Multiple RTK inputs can cause cells to divide, replicate DNA, and undergo cytokinesis to create two new cells
What do RTK inputs stimulate?
- They stimulate survival pathways through the activation on PI3K and PKB
- Stimulate cell differentiation which is important in specialisation of cells for example differentiation of blood cells into red and white
What happens if you remove growth factor stimulation?
When you remove growth factor stimulation this causes cells to die which is also a regulated response, there are two types: apoptosis and necrosis
What happens to RTKs during cancer?
What happens during cancer is there is hyperactivation of stimulation of RTKs, often in the absence of ligand
o So, in this case what happens is the cells lose their ability to die, we get uncontrolled promotion of cell survival, cells undifferentiate so they return to a simpler state and divide uncontrollably
What research has been done in oncogenes and cell growth?
Considerable effort has been made to characterise the signal transduction pathways involved in the control of cell growth and proliferation by growth actor and oncogenes
What has the study of cell transformation lead to?
The study of cell transformation by oncogenes has led to many advances in the elucidation of normal cell proliferation control pathways
What work first suggested a link between growth factors and growth of cancer cells?
The first suggestion of a link between growth factors and growth of cancer cells came from work suggesting that transformed cells might synthesise and secrete growth factors which would act in an AUTOCRINE or PARACRINE fashion to stimulate growth
What can mutations result in (relating to oncogenesis)?
There are normally growing cells but sometimes mutations occur that lead to aberrant cell proliferation
* So uncontrolled cell proliferation we get expansion of the population and they start to swamp the normally growing cells so they become the minor growing population
What can be amongst the senescent cells?
Amongst the senescent cells we begin to generate cancer cells and they can proliferate
o At this point we have loss of tumour suppressors which normally control proliferation
o There is also expansion of malignant cells
Timeline of the discovery of oncogenes
1916- Francis Peyton Rous
- Rous sarcoma virus
- Ground up cancerous tumour from a chicken and filtered out everything larger than a virus
- The resulting liquid produced cancer when injected into other chicken
1966- Rous shared the Nobel Prize for Physiology or Medicine for his work
1976- J. Michael “Moke” Bishop and Harold Varmus discover oncogenes
-Identified the src gene as a cancer-causing gene is Rous sarcoma virus
- Whose normal functions have gone awry
1989 - Bishop and Various win the Nobel Prize in Physiology or Medicine
What was most important about the discovery of oncogenes?
More important than the technical details was the revolution this caused in thinking about cancers
How many known oncogenes are there?
There are now over 80 known oncogenes that have been identified
Quote by J.M. Bishop?
“If a cellular gene can cause cancer, then aberrations of normal cellular metabolism can cause cancer” -J.M. Bishop
What are oncogenes?
Mutated versions of normal regulatory genes (proto-oncogenes)
Where are oncogenes from?
From host genome (c-onc) or viruses (v-onc)