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Hemostasis and Thrombosis > 2.3 > Flashcards

2.3 Flashcards

1
Q

The APTT is sensitive to a deficiency of which clotting factor?
a. Factor VII
b. Factor X
c. PF3
D. Calcium

A

b. Factor X

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2
Q

Which test result would be normal in a patient with dysfibrinogenemia?
a. TT
b. APTT
c. PT
d. Immunologic fibrinogen level

A

d. Immunologic fibrinogen level

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3
Q

A patient with a prolonged PT is given IV vitamin K. PT is corrected to normal after 24 hours. Which clinical condition most likely caused these results?
a. Necrotic liver disease
b. Factor X deficiency
c. Fibrinogen deficiency
d. Obstructive jaundice

A

d. Obstructive jaundice

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4
Q

Which factor deficiency is associated with prolonged PT and APTT?
a. Factor X
b. Factor VIII
c. Factor IX
d. Factor XI

A

a. Factor X

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5
Q

A prolonged APTT is corrected with factor VIII-deficient plasma but not with factor IX-deficient plasma. Which factor is deficient?
a. Factor V
b. Factor VIII
c. Factor IX
d. Factor X

A

c. Factor IX

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6
Q

Which of the following is a characteristic of classic hemophilia A?
a. abnormal PLT aggregation
b. Autosomal recessive inheritance
c. Mild to sever bleeding episodes
d. Prolonged PT

A

c. Mild to sever bleeding episodes

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7
Q

Refer to the following results:
PT = prolonged APTT = Prolonged PLT count = Decreased
Which disorder might be indicated?
a. Factor VIII deficincy
b. vW Disease
c. DIC
d. Factor IX deficiency

A

c. DIC

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8
Q

Which of the following is a predisposing condition for the development of DIC?
a. Adenocarcinoma
b. Idiopathic thrombocytopenia purpura (ITP)
c. Post transfusion purpura (PTP)
d. Heparin-induced Thrombocytopenia (HIT)

A

a. Adenocarcinoma

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9
Q

Factor XII deficiency is associated with:
a. Bleeding episodes
b. Epistasis
c. decreased risk of thrombosis
d. increased risk of thrombosis

A

d. increased risk of thrombosis

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10
Q

The following results were obtained on a patient: normal PLT count and function, normal PT, and prolonged APTT. Which of the following disorders is most consistent with these results?
a. hemophilia A
b. Benard-soulier syndrome
c. vW disease
d. Glanzmann thrombasthenia

A

a. hemophilia A

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11
Q

The following lab results were obtained from a 40-year-old woman: PT: 20 sec; APTT 50 sec; TT 18 sec. What is the most probably diagnosis?
a. Factor VII deficiency
b. Factor VIII deficiency
c. Factor X deficiency
d. Hypofibrinogenemia

A

d. Hypofibrinogenemia

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12
Q

When performing a factor VIII activity assay, a patient’s plasma is mixed with:
a. Normal patient plasma
b. Factor VIII-deficient plasma
c. plasma with a high concentration of factor VIII
d. normal control plasma

A

b. Factor VIII-deficient plasma

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13
Q

The most suitable product for treatment of facto VIII deficiency is:
a. Fresh frozen plasma (FFP)
b. Factor VIII concentrate
c. Prothrombin complex concnetrate
d. factor V leiden

A

b. Factor VIII concentrate

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14
Q

Which of the following is associated with an abnormal PLT aggregation test result?
a. Factor VIII deficiency
b. Factor VIII inhibitor
c. lupus anticoagulant
d. afibrinogenemia

A

d. afibrinogenemia

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15
Q

Refer to the following results:
PT: Normal, APTT: Prolonged, PLT count: Normal, PLT aggregation to ristocetin: Abnormal
a. Factor VIII deficiency
b. DIC
c. vW disease
d. Factor IX deficiency

A

c. vW disease

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16
Q

Which results are associated with hemophilia A?
a. Prolonged APTT, normal PT
b. Prolonged PT and APTT
c. Prolonged PT, Normal APTT
d. Factor IX deficiency

A

a. Prolonged APTT, normal PT

17
Q

Fibrin monomers are increased in which of the following conditions?
a. primary fibrinolysis
b. DIC
c. Factor VIII deficiency
d. Fibrinogen deficiency

A

b. DIC

18
Q

Which of the following is associated with multiple factor deficiencies?
a. an inherited disorder of coagulation
b. severe liver disease
c. dysfibrinogenemia
d. lupus anticoagulant

A

b. severe liver disease

19
Q

Normal PT and APTT results in a patient with poor wound healing may be associated with:
a. Factor VII deficiency
b. Factor VIII deficiency
c. Factor XII deficiency
d. Factor XIII deficiency

A

d. Factor XIII deficiency

20
Q

Fletcher factor (prekallikrein) deficiency may be associated with:
A. Bleeding
B. Thrombosis
C. Thrombocytopenia
D. Thromboscytosis

A

B. Thrombosis

21
Q

One of the complications associated with a severe hemophilia A is:
a. hemarthrosis
b. mucous membrane bleeding
c. mild bleeding during surgery
d. immune-mediated thrombocytopenia

A

a. hemarthrosis

22
Q

The most common subtype of classic von Willebrand disease?
a. Type 1
b. Type 2a
c. Type 2b
d. Type 3

A

a. Type 1

23
Q

Prolonged APTT and PT are corrected when mixed with normal plasma, which factor is most likely deficient?
a. Factor VIII
b. Factor V
c. Factor XI
d. Factor IX

A

b. Factor V

Hemostasis and Thrombosis (5 decks)

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