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Hemostasis and Thrombosis > 2.1 > Flashcards

2.1 Flashcards

1
Q

Which of the following initiates in vivo coagulation by activation of factor VII?
a. Protein C
b. Tissue Factor (TF)
c. Plasmin Activator
d. Thrombomodulin (TM)

A

b. Tissue Factor (TF)

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2
Q

Which of the following clotting factors plays a role in clot formation in vitro, but not in vivo?
a. Factor VIIa
b. Factor IIa
c. Factor XIIa
d. Factor Xa

A

c. Factor XIIa

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3
Q

The anticoagulant of choice for most routine coagulation studies is:
a. Sodium oxalate
b. sodium citrate
c. heparin
d. EDTA

A

b. sodium citrate

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4
Q

Which anticoagulant to blood ratio is correct for coagulation procedures?
a. 1:4
b. 1:5
c. 1:9
d. 1:10

A

c. 1:9

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5
Q

Which results would be expected for PT and APTT in a patient with polycythemia?
a. both prolonged
b. both shortened
c. Normal PT, prolonged APTT
d. Both Normal

A

a. both prolonged

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6
Q

Which reagents are used in the PT Test?
a. Thromboplastin and sodium citrate
b. Thromboplastin and potassium chloride
c. Thromboplastin and calcium
d. Actin and Calcium cloride

A

c. Thromboplastin and calcium

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7
Q

Which test would be abnormal in a patient with factor X deficiency?
a. PT only
b. APTT only
c. PT and APTT
d. Thrombin Time (TT)

A

c. PT and APTT

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8
Q

Which clotting factor is NOT measured by the PT and APTT tests?
a. Factor VIII
b. Factor IX
c. Factor V
d. Factor XIII

A

d. Factor XIII

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9
Q

A modification of which procedure can be used to measure fibrinogen?
a. PT
b. APTT
c. TT
d. Fibrin degradation products

A

c. TT

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10
Q

Which of the following characterizes vitamin K?
a. It is required for biological activity of fibrinolysis
b. Its activity is enhanced by heparin therapy
c. It is required for carboxylation of glutamate residues of some coagulation factors
d. It is made by endothelial cells

A

c. It is required for carboxylation of glutamate residues of some coagulation factors

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11
Q

Which fragments of fibrin clot degradation are measured by the D-dimer test?
a. Fragments X and Y
b. Fibrinopeptide A and B
c. Fragments D and E
d. The D-D domains

A

d. The D-D domains

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12
Q

Which of the following clotting factors are measured by the APTT test?
a. Factors II, VII, IX, and X
b. Factors VII, X, V, II, I
c. Factors XII, XI, IX, VIII, X, V, II, I
d. Factors XII, VII, X, V, II, I

A

c. Factors XII, XI, IX, VIII, X, V, II, I

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13
Q

Which coagulation test(s) would be abnormal in a patient with Vitamin K deficiency?
a. PT only
b. PT and APTT
c. Fibrinogen level
d. TT

A

b. PT and APTT

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14
Q

Which of the following is correct regarding the international normalized ratio (INR)?
a. It uses the international sensitivity ratio (ISR)
b. It standardizes PT results
c. It standardizes APTT results
d. It is used to monitor heparin therapy

A

b. It standardizes PT results

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15
Q

Which of the following is referred to as an endogenous activator of plasminogen?
a. Streptokinase
b. Transamidase
c. Tissue plasminogen activator (tPA)
d. tPA inhibitor

A

c. Tissue plasminogen activator (tPA)

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16
Q

Which protein is the primary inhibitor of the fibrinolytic system?
a. Protein C
b. Protein S
c. A2-antiplasmin
d. A2-macroglobulin

A

c. A2-antiplasmin

17
Q

Which of the following statements is correct regarding the D-dimer test?
a. Levels are decreased in DIC
b. Test detects polypeptides A and B
c. Test detects fragments D and E
d. Test has a negative predictive value

A

d. Test has a negative predictive value

18
Q

A protein that plays a role in both coagulation and PLT aggregation is:
a. Factor I
b. Factor VIII
c. Factor IX
d. Factor XI

A

a. Factor I

19
Q

A standard 4.5 mL blue top tube is filled with 3.0 mL of blood was submitted to the laboratory for PT and APTT tests. The sample is from a patient undergoing surgery the following morning for a tonsillectomy. Which is the necessary course of action by the technologist?
a. Run both tests in duplicate and report the average result
b. reject the sample and request a new sample
c. report the PT result
d. report the APTT result

A

b. reject the sample and request a new sample

20
Q

Which statement is correct regarding sample storage for the PT test?
a. Stable for 24 hours if the sample is capped
b. Stable for 24 hours if the sample is refrigerated at 4 C
c. Stable for 4 hours if the sample is stored at 4 C
d. Should be run within 8 hours

A

a. Stable for 24 hours if the sample is capped

21
Q

In primary fibrinolysis, the fibrinolytic activity results in response to:
a. increased fibrin formation
b. spontaneous activation of fibrinolysis
c. increased fibrin monomers
d. DIC

A

b. spontaneous activation of fibrinolysis

22
Q

Plasminogen deficiency is associated with:
a. Bleeding
b. thrombosis
c. increased fibrinolysis
d. increased coagulation

A

b. thrombosis

23
Q

Which of the following clotting factors are activated by thrombin that is generated by tissue pathway (TF-VIIa)?
A. Factors XII, XI
B. Factors XII, I
C. Factors I, II
D. Factors V, VIII

A

D. Factors V, VIII

24
Q

Which substrate is used in a chromogenic/amidolytic factor assay?
A. p-nitroaniline (pNA)
B. Chlorophenol Red
C. Prussian Blue
D. Ferricyanide

A

A. p-nitroaniline (pNA)

25
Q

Which of the following antibodies is used in the D-Dimer assay?
A. Polyclonal antibody directed against X and Y fragments
B. Polyclonal antibody directed against D-dimer
C. Monoclonal antibody against D and E fragments
D. Monoclonal antibody against D-dimer

A

D. Monoclonal antibody against D-dimer

Hemostasis and Thrombosis (5 decks)

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