22.12 Pharmacotherapy: Antipsychotics (Doses)

Question 1

Name typical antipsychotic agents (2)

Answer 1

• Haloperidol (Haldol®)
• Chlorpromazine (Largactil®)

Question 2

Name doses: Haloperidol (Haldol®)

• Starting dose
• Maintenance
• Maximum

Answer 2

• Starting dose:
  
  • 2-5 mg IM q4-8h
  • 0.5-5 mg PO b/tid
  • 0.2 mg/kg/d PO
  • Based on clinical effect
• Maintenance:
  
  • Based on clinical effect
  • 20 mg/d PO
• Maximum: 20 mg/d PO

Question 3

Name doses: Chlorpromazine (Largactil®)

• Starting dose
• Maintenance
• Maximum

Answer 3

• Starting dose: 10-25 mg PO b/t/qid
• Maintenance: 400 mg/d PO
• Maximum: 1000 mg/d PO

Question 4

Name atypical antipsychotic agents (in order of potency from high to low) (6)

Answer 4

• Risperidone (Risperdal®, Risperdal Consta® for IM long acting preparation, Risperdal® M-Tab for melting form – placed on tongue)
• Paliperidone (Invega®)
• Olanzapine (Zyprexa®, Zyprexa Zydis® for melting form – placed on tongue, Zyprexa Intramuscular®)
• Aripiprazole (Abililfy®)
• Quetiapine (Seroquel®, Seroquel XR® for extended release®)
• Clozapine (Clozaril®)

Question 5

Name doses: Risperidone

• Starting dose
• Maintenance
• Maximum

Answer 5

• Starting dose: 1-2 mg OD/bid
• Maintenance:
  
  • 4-8 mg/d PO
  • 25 mg IM q2wk
• Maximum: 8 mg/d PO

Question 6

Name doses: Paliperidone (Invega®)

• Starting dose
• Maintenance
• Maximum

Answer 6

• Starting dose: 3 mg/d PO
• Maintenance: 3-12 mg /d PO
• Maximum: 12 mg/d PO

Question 7

Name doses: Olanzapine (Zyprexa®, Zyprexa Zydis® for melting form – placed on tongue, Zyprexa Intramuscular®)

• Starting dose
• Maintenance
• Maximum

Answer 7

• Starting dose: 5 mg/d PO
• Maintenance: 10-20 mg/d PO
• Maximum: 30 mg/d PO

Question 8

Name doses: Aripiprazole (Abililfy®)

• Starting dose
• Maintenance
• Maximum

Answer 8

• Starting dose: 10-15 mg/d PO
• Maintenance: 10-15 mg/d PO
• Maximum: 30 mg/d PO

Question 9

Name doses: Quetiapine (Seroquel®, Seroquel XR® for extended release®)

• Starting dose
• Maintenance
• Maximum

Answer 9

• Starting dose: 25 mg PO bid
• Maintenance: 400-800 mg/d PO
• Maximum: 800 mg/d PO

Question 10

Name doses: Clozapine (Clozaril®)

• Starting dose
• Maintenance
• Maximum

Answer 10

• Starting dose: 25 mg PO bid
• Maintenance: 300-600 mg/d PO
• Maximum: 600 mg/d PO