(2.2) Lymphatics Flashcards
Describe an overview of the lymphatic drainage system.
Lymphatic capillaries -> Afferent Lymphatic Vessels -> Lymph Nodes -> Efferent Lymphatic Vessels -> Lymphatic Trunks -> Collecting Ducts -> Subclavian Veins
Describe the structures within a lymph node.
- Afferent lymphatic vessels going in & Efferent lymphatic vessel going out
- Lymphatic sinuses
- Parenchyma = Cortex (outer) & Paracortex (middle) & Medulla (centre)
What are the roles of lymph nodes?
- Phagocytic cells act as a filter of micro-organisms and particles
- Antigen presenting to activate adaptive and innate immune system
Name 2 Primary Lymph organs.
- Bone marrow
- Thymus (under sternum)
Name some Secondary lymph organs. Suggest some places where they can be found.
- Spleen
- Lymph nodes
- Lymphoid follicles
- Tonsils
- MALTs
- GALTs (Adenoid, Peyer’s patches)
Suggest some places where there is a high concentration of lymph nodes.
- Head and Neck
- Axilla
- Groin
What cells can be found in the 3 layers of a parenchyma of a lymph node?
- Cortex: B cells
- Paracortex: T cells & activated B cells
- Medulla: Macrophages & Plasma cells & B memory cells
How do you distinguish a Lymphadenopathy caused by an infection and a malignancy anatomically? What symptoms do they both cause?
- Infection: tender & smooth
- Malignancy: non-tender & craggy
- Sore throat & Dysphagia
What is the most common malignancy in head and neck? What symptoms does it cause?
- Squamous cell carcinoma
- Lymphadenopathy
- Sore throat
- Dysphagia
What is the most common virus cause of Glandular fever? What symptoms does it cause?
- Epstein Barr Virus
- Lymphadenopathy
- Sore throat
- Dysphagia
- Fever & fatigue
Describe the organisation and drainage of the lymph nodes in H&N.
- Regional group x12 groups
- Terminal group x3 groups
- All lymph nodes drain into Jugular Trunks either directly or via Terminal lymph nodes
Give some examples of the regional lymph nodes.
- Occipital
- Post-auricular (Mastoid)
- Pre-auricular (Parotid)
- Buccal (Facial)
- Submental
- Submandibular
- Anterior & Posterior Cervical
- Superficial Cervical - along the External Jugular Vein
What are the three groups of Terminal Lymph Nodes? Where are they found?
- Internal Jugular
- Supraclavicular
- Spinal Accessory
- Found along the Internal Jugular Vein e.g. deep within Carotid Sheath
Tonsillitis causes lymphadenopathy of?
Lymphadenopathy of Jugulo-Digastric node associated with?
Oral cancer causes lymphadenopathy of?
Lymphadenopathy of Jugulo-Omohyoid Node associated with?