22-23 Intro to CNS Drugs

Question 1

Na channel blocker, puffer fish

Answer 1

Tetrodotoxin

Question 2

Nicotinic Ach receptor antagonist (ligand gated), binds irreversibly and competitively to the Ach receptor at NMJ paralysis, snake venom

Answer 2

Alpha-bungarotoxin

Question 3

GABAA Receptor antagonist (ligand gated), noncompetive antagonist to GABA Cl channels (channel blocker), south pacific plant

Answer 3

Picrotoxin

Question 4

Glycine receptor antagonist (ligand gated), opens Cl channels convulsions/prolonged activity in motor neurons, Indian Plant

Answer 4

Stychnine

Question 5

Nucleus in the pons that is involved with physiological responses to stress and panic (produces NE)

Answer 5

Locus coeruleus

Question 6

Order of metabolism of the 3 catecholamines

Answer 6

Tyrosine, Dopa, Dopamine, Norepinephrine, Epinephrine

Question 7

an NE reuptake inhibitor—prolongs the effect of NE

Answer 7

Cocaine

Question 8

Name three SNRIs

Answer 8

Desipramine, Maprotyline, and Protryptiline

Question 9

Contraindication of SNRIs

Answer 9

Pt being treated for hypertension with Guanethedine, which blocks NE release upon being brought in by NE transporters (SNRIs block NE transporters)

Question 10

Release NE by disrupting synaptic vesicle transporters

Answer 10

Rauwolfia alkaloids (like reserpine)

Question 11

3 dopaminergic pathways, disease associated, and treatment of that disease

Answer 11

1- Nigrastriatal, Parkinsons, bind DA to receptors
2- Mesolimbic, psychosis, D2 receptor antagonists
3- Tuberofundibular, hyperprolactinemia, dopamine inhibits release of prolactin

Question 12

Levodopa + Carbidopa

Answer 12

Sinemet

Question 13

inhbits peripheral metabolis of l-dopa so that more crosses the BBB for a greater CNS affect (via inhibition of dopa decarboxylase)

Answer 13

Carbidopa

Question 14

Types of Phenothiazines (anti-psychotics)

Answer 14

Spiroperidol, Pimozide, Haloperidol

Question 15

primary nucleus of serotonin production

Answer 15

Raphe magnus

Question 16

Target of antidepressants

Answer 16

Serotonin Receptors/5HT projection sites

Question 17

SSRIs

Answer 17

Fluoxetine, escitalopram, fluvoxamine, paroxetine, trazodone, imipramine (+/-)

Question 18

GABA stimulation causes

Answer 18

hyperpolarization due to Cl influx resulting in CNS depression

Question 19

drug that stimulates GABA

Answer 19

Barbituates

Question 20

Increases GABA binding by binding to a seperate site on the GABA receptor complex/ anti-anxiety medication

Answer 20

Benzodiazepines

Question 21

Two important benzodiazepines

Answer 21

valium and librium

Question 22

Ach receptor and agonist

Answer 22

Musacrinic (M1), Musacrine

Question 23

Dopamine receptor and agonist

Answer 23

D1; D2, None; bromocriptine

Question 24

GABA receptor and agonist

Answer 24

GABAa, Muscimol, barbituates

Question 25

Glutamate receptor and agonist

Answer 25

Glutamate receptor, NMDA

Question 26

Glycine receptor and agonist

Answer 26

Glycine receptor, Taurine, B-alanine

Question 27

5HT (serotonin) receptor and agonist

Answer 27

5HT1a, LSD