16-17 Principles of Cancer Chemotherapy

Question 1

Equation for chemotherapeutic index (CTI)

Answer 1

CTI= Toxicity to Cancer Cells (LD50)/Toxicity to Normal Cells

Question 2

Name some cells that are susceptible to chemotherapy

Answer 2

Sperm, hair follicles, GI cells, not oocytes

Question 3

Drug resistance can be reversed by ________ by _______________

Answer 3

Verapamil, quinidine, cyclosporine by blocking calcium channels

Question 4

Over expression of this protein increases resistance to anthracyclines and vinca alkyloids

Answer 4

MRP

Question 5

Expression of _____ causes greater production of _______ which is involved with drug efflux

Answer 5

MDR1, cell surface p-glycoproteins

Question 6

Know the 3 effects of myelosuppresion and symptoms of each

Answer 6

Lower WBCs, RBCs, and platelets

Question 7

3 Serotonin receptor antagonists and their importance

Answer 7

Dolasetron, Granisetron, Ondansetron; first line of therapy to treat N and V

Question 8

3 Anti-dopaminergic drugs and their importance

Answer 8

Prochloroperazine, Fluphenazine, Chlorpromazine; second line of therapy to treat N and V

Question 9

Anticancer agents currently listed as susceptible to MDR-1 mediated resistance

Answer 9

Anthracyclines, vinca alkyloids, paclitaxel, etoposide, mitomycin, plicamycin
PPVEAM

Question 10

Drug given to increase RBCs in anemic cancer pt

Answer 10

Recombinant Erythropoeitin

Question 11

ABVD

Answer 11

Adriamycin, bleomycin, vinblastine, and dacarbazine

Question 12

MOPP

Answer 12

Mustargen, Oncovin, Procarbazine, Prednisone