21.4 NS: Cellular basis of behavioural illness Flashcards
1
Q
What is OCD behaviour linked to changes in?
What happens if we knockout this in mice?
A
Microglia- HoxB8 (knockout=exscessive grooming)
2
Q
What is the WRT pathway important in?
A
Neuronal development (cell becoming a neuron or glia)
3
Q
What is abnormal in autism? (3 points)
A
- Microglia
- Dorsolateral prefrontal cortex
- Increase in grey matter density, increase in gre/white volume
4
Q
What are SNPs in autism a balance between?
A
Protective and risk factors