2.1 CYTOKINES/ GROWTH FACTORS Flashcards

1
Q

EPO PCS

A

❖ Kidney (peritubular interstitial cell)

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2
Q

EPO PTC

A

❖ Bone marrow erythroid progenitors (BFU-E and CFU-E)

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3
Q

EPO BA

A

❖ Simulates proliferation of erythroid progenitors and prevents apoptosis of CFU-E

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4
Q

G-CSF PTC

A

❖ Neutrophil precursors
❖ Fibroblasts
❖ Leukemic myeloblasts

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5
Q

G-CSF BA

A

❖ Stimulates granulocyte colonies ❖ Differentiation of progenitors toward neutrophil lineage
❖ Stimulation of neutrophil maturation

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6
Q

GM-CSF PTC

A

❖ Bone marrow progenitor cells
❖ Dendritic cells
❖ Macrophages
❖ NKT cells

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7
Q

GM-CSF BA

A

❖ Promotes antigen presentation
❖ T cell homeostasis
❖ Hematopoietic cell growth factor

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8
Q

IL-2 PTC

A

❖ T cells
❖ NK cells
❖ B cells
❖ Monocytes

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9
Q

IL-2 BA

A

❖ Cell growth/activation of CD4+ and CD8+ T cells
❖ Suppress Treg responses
❖ Mediator of immune tolerance

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10
Q

IL-3 PTC

A

❖ Hematopoietic stem cells and progenitors

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11
Q

Multi potential CSF

A

IL-3

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12
Q

IL-3 Works with?

A

SCF

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13
Q

IL3 WORKS WITH SCF FOR?

A

BASOPHIL DIFFERENTIATION

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14
Q

IL-3 BA

A

❖ Proliferation of hematopoietic progenitors

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15
Q

IL-3 difference with GM-CSF

A

IL-3 works at earlier level

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16
Q

IL-5 BA

A

Eosinophil differentiation
Activates cytotoxic T-cells
Induces immunoglobulin secretion

17
Q

IL-6 BA

A

Duplication and or differentiation of committed CFU-G and CFU-M/CMT

❖ Co-stimulation with other cytokines
❖ Cell growth/activation of T cells and B cells
❖ Megakaryocyte maturation
❖ Neural differentiation
❖ Acute phase reactant

18
Q

IL -9 BA

A

T Cell growth factor
Mast cell activating factor

19
Q

IL-6 PTC

A

❖ T cells
❖ B cells
❖ Liver

20
Q

IL-10 PTC

A

❖ T cells
❖ Macrophages

21
Q

IL-10 BA

A

❖ Inhibits cytokine production
❖ Inhibits macrophages

22
Q

IL-12 PTC

A

❖ T cells

23
Q

IL-12 BA

A

❖ T cell, Th1 differentiation

24
Q

IL-15 PTC

A

❖ CD4+ T cells
❖ CD8+ T cells
❖ NK cells

25
Q

IL-15 BA

A

❖ CD4+/CD8+ T cell proliferation
❖ CD8+/NK cell cytotoxicity

26
Q

IFN- (ALPHA) PTC

A

❖ Macrophages
❖ NK cells

27
Q

IFN- (INTERFON ALPHA) BA

A

❖ Antiviral
❖ Enhances MHC expression

28
Q

Treatment for neutropenia

A

G-CSF

29
Q

Panmyeloid hematopoietic growth factor

A

GM-CSF