2.1 CYTOKINES/ GROWTH FACTORS Flashcards
EPO PCS
❖ Kidney (peritubular interstitial cell)
EPO PTC
❖ Bone marrow erythroid progenitors (BFU-E and CFU-E)
EPO BA
❖ Simulates proliferation of erythroid progenitors and prevents apoptosis of CFU-E
G-CSF PTC
❖ Neutrophil precursors
❖ Fibroblasts
❖ Leukemic myeloblasts
G-CSF BA
❖ Stimulates granulocyte colonies ❖ Differentiation of progenitors toward neutrophil lineage
❖ Stimulation of neutrophil maturation
GM-CSF PTC
❖ Bone marrow progenitor cells
❖ Dendritic cells
❖ Macrophages
❖ NKT cells
GM-CSF BA
❖ Promotes antigen presentation
❖ T cell homeostasis
❖ Hematopoietic cell growth factor
IL-2 PTC
❖ T cells
❖ NK cells
❖ B cells
❖ Monocytes
IL-2 BA
❖ Cell growth/activation of CD4+ and CD8+ T cells
❖ Suppress Treg responses
❖ Mediator of immune tolerance
IL-3 PTC
❖ Hematopoietic stem cells and progenitors
Multi potential CSF
IL-3
IL-3 Works with?
SCF
IL3 WORKS WITH SCF FOR?
BASOPHIL DIFFERENTIATION
IL-3 BA
❖ Proliferation of hematopoietic progenitors
IL-3 difference with GM-CSF
IL-3 works at earlier level
IL-5 BA
Eosinophil differentiation
Activates cytotoxic T-cells
Induces immunoglobulin secretion
IL-6 BA
Duplication and or differentiation of committed CFU-G and CFU-M/CMT
❖ Co-stimulation with other cytokines
❖ Cell growth/activation of T cells and B cells
❖ Megakaryocyte maturation
❖ Neural differentiation
❖ Acute phase reactant
IL -9 BA
T Cell growth factor
Mast cell activating factor
IL-6 PTC
❖ T cells
❖ B cells
❖ Liver
IL-10 PTC
❖ T cells
❖ Macrophages
IL-10 BA
❖ Inhibits cytokine production
❖ Inhibits macrophages
IL-12 PTC
❖ T cells
IL-12 BA
❖ T cell, Th1 differentiation
IL-15 PTC
❖ CD4+ T cells
❖ CD8+ T cells
❖ NK cells
IL-15 BA
❖ CD4+/CD8+ T cell proliferation
❖ CD8+/NK cell cytotoxicity
IFN- (ALPHA) PTC
❖ Macrophages
❖ NK cells
IFN- (INTERFON ALPHA) BA
❖ Antiviral
❖ Enhances MHC expression
Treatment for neutropenia
G-CSF
Panmyeloid hematopoietic growth factor
GM-CSF
