21-22

Question 1

Diabetic nephropathy is characterized by ___

Answer 1

Proteinuria >300 mg/day on at least 2 occasions separated by 3-6 months

Question 2

Hallmarks of diabetic nephropathy

Answer 2

HTN
Progressive increase in proteinuria
Progressive decline in GFR

Question 3

Screening recommendations for microalbuminuria

Answer 3

Type I diabetic dx for more 3-5 years and over 12 years check annually
-all type II diabetics check annually

Question 4

Treatment for anyone with proteinuria?

Answer 4

ACEI or ARB

If that doesn’t work use diltIazem or verapamil (nondihydropyridines CCBs)

Question 5

Most common causes of kidney failure

Answer 5

Diabetes

Then HTN

Question 6

Stages of CKD

Answer 6

1. > 90 GFR
2. 60-89
3. 30-59
4. 15-29
5. <15 not on dialysis = kidney failure
6. <15 on dialysis = ESRD

Question 7

Advanced stage of CKD when multiorgan system derangements become clinically manifested

Answer 7

Uremia

Question 8

Don’t use rosuvastatin in CKD because ___

Answer 8

Very potent
Intensifies proteinuria
Impairs renal function

Question 9

1st, 2nd, and 3rd line therapies for CKD

Answer 9

ACEI/ARB
CCB - nondihydropyridines
Diuretic

Question 10

Use ___ in patients with elevated uric acid.

Side effect?

Answer 10

Allopurinol

Stevens-Johnson syndrome (skin rxn)

Question 11

Tx for uremic coagulopathy

Answer 11

Cryoprecipitate
Desmopressin
Estrogen
Dialysis

Question 12

Uremic coagulopathy dx test

Answer 12

Bleeding time

-others will be normal (PT, PTT, INR)