2.09 - Hip Fractures, Surgery and DVT Flashcards
What is the function and composition of ligament tissue?
- Resist tension
- Collagen I
What is the function and composition of tendon tissue?
- Resist tension
- Collagen I
What is the function and composition of cartilage?
- Resist compression
- Collagen I
What is the function and composition of fibrocartilage?
- Resist compression
- Collagen I + II
What is the function and composition of bone?
- Resist compression
- Hydroxyapatite
What is the function and composition of synovium?
- Provide lubrication
- Mainly cellular
What is the function and composition of muscle?
- Relaxation and contraction
- Myocytes
What is the function and structure of elastic cartilage?
- Irregualar structure, Large cells
- Type II
- Eg. Pinna
What is the function and structure of hyaline cartilage?
- Most common type
- Type II collagen
- Shock absorption
- Provides an articular surface
What are the different types of bone?
- Long
- Short
- Flat
- Irregular
- Sesamoid
What are the two strutural types of bone?
- Cortical (Compact)
- Trabecular (Spongy)
What are the functions of bone?
- Calcium storage
- Visceral support
- Protection
- System of levers
- Possible endocrine function?
- Haematopoiesis
What is the structure of woven bone?
- Primary type
- Involved in fracture repair and embryonic development
What is the function of lamellar bone?
- Bone of the skeleton
- Can either be compact or spongy
What is the extracellular matrix of bone?
- Molecules that provide biochemical and structural support to the cells
- Eg. Calcium Hydroxyapatite
What are the different cell types found in bone?
- Osteocytes
- Osteoclasts
- Osteoblasts
- Lining cells
What is the function of osteoblasts?
- Principle function of bone formation
- Synthesis bone matrix and ensure it is primed
- Large cuboidal cells
- Form an epithelial layer on the cell surface
What is the function of osteocytes?
- Mature blast cells that are engulfed in matrix during mineralisation -> Entombed in bone matrix
- Relied on canaliculi to maintain junctions with other entombed cells
What is the function of osteoclasts?
- Large multinucleated cells responsible for the reabsorption of bone
- Distinct ruffled border appearance
What is the function of lining cells?
- Mature blast cells that can be reactivated
- Play a role in bone remodelling
What is type I collagen?
- Made bone proteogylcan and some other non-callagenous proteins such as osteocalcin, osteorectin, osteopontin
What is hydroxyapatite?
- Mineral
- Complex calcium-phosphate salt molecule
What is the fucntion of compact bone?
- Strength
- High density
What are the two types of bone ossification?
- Endochondral
- Intramembranous
How does intramembranous ossification occur?
- Via remodelling of mesenchymal connective tissue that acts as blueprint
- Growth occurs from inside to outside
- Framework becomes calcified and traps osteoblasts
In which bones does intramembranous ossification occur?
- Flat bones
What is the function of mesenchymal cells?
- Acts as blueprint framework
- From periosteum on the outer surface
How does endochondral ossification occur?
- When bone forms in the place of a hyaline cartilage precursor
- Chondrocyte death occurs in the cartilage which allows inward migration of osteoblasts
- Involves growth plates
Which bones does endochondral ossification take place?
- Long bones
- Bones that utilise growth plates
How do bones heal?
- Process of bone remodelling
- Bone callous forms which is then reformed into mature bone
- Can return to original form and strength
How do tendons repair?
- Limited ability to heal
- Has a poor blood supply which contributes to the slower healing process
- Inflammatory process
- Fibroblasts
How do muscles heal?
- Have a limited ability to heal similar to tendons
- Satellite cells (type of muscle cell) become activated and proliferate then differentiate into myoblasts
- These fuse to form new muscles cells
- Not returned to original strength
How does being elderly effect fracture incidence?
- Increasing age is a ris factor for fractures
- Due to increased incidence of osteoporosis
How does osteoporosis occur?
- Imbalance of bone breakdown and bone formation leads to a reduction in the density of bone
What is osteoporosis?
- Characterised by low bone mass and micro-architectural deterioration of bone
- This results in increased fragility
What level of bone mass density is classed as osteoporotic?
- When bone mineral density is 2.5 standard deviations below mean peak mass for their age
What is the epidemiology behind osteoporosis?
- Affects over 2 million people in the UK
- Prevalence increases with age
Which group are most at risk of osteoporosis?
- Post-menopausal women
What are the clinical features associated with osteoporosis?
- Bones that break more easily
- Crumbly bone appearance
- Stooped posture
- Loss of height
Why does osteoporosis occur?
- Increased osteoclast activity
- Level osteoblast activity
How do glucocorticoids increase risk of osteoporosis?
- They can stimulate increased turnover of bone which can lead to osteoporosis
What are the two types of risk factors seen in the development of osteoporosis?
- BMD dependant
- BMD independant
What are some BMD dependant risk factors for osteoporosis?
- Female sex
- Causcasian/Asian
- CKD
- Vitamin D deficiency
- Chronic liver disease
- Endocrine disorders
- Multiple myeloma
- Osteogenesis imperfecta
What are some BMD independant risk factors for osteoporosis?
- Previous fragility fracture
- FHx
- Corticosteroids
- Alcohol (3+ units a day)
- Smoking
- Low BMI
- Rheumatoid arthritis
What is a low BMD associated with?
- Significant increased fracture risk from low impact events such as a fall from standing height
What is the normal first-line treatment for osteoporosis?
- Oral biphosphonates
- Alendronate - 30 minutes before food
- Zoledronic acid - IV injection once a year
How does denosumab help with the treatment of osteoporosis?
- Inhibits osteoclast formation/survival
- Type of human monoclonal antibody
- Decreases bone resorption
How is raloxifene used in osteoporosis management?
- Selective estrogen receptor modulator
- Decreased bone resorption
- Increased risk of VTE and stroke
What lifestyle factors can be addressed in osteoporosis?
- Smoking
- Alcohol
- Falls assessment
How is hormone replacement therapy used in osteoporosis?
- Form of oestrogen +/- progesterone
- Prevention of fractures in women
- Used in younger women
- Multiple side effects
What tool can be used to assess a persons risk of fracture over a 10 year period?
- FRAX
- QFracture
What is the pathophysiology behind osteoporosis?
- Increased osteoclast activity
- This leads to increased breakdown of bone
- This is unmatched by osteoblast activity
- Bone mass decreases
What is investigation is used to assess bone mass density?
- Dual-energy X-ray absorptiometry (DXA) scan
What are the meanings behind DXA scan results?
- Scored with a T-score
- > -1 = normal
- -1 -> -2.5 = osteopenia
- ≤ -2.5 = osteoporosis
What are some secondary causes of osteoporosis?
- Endocrine conditions
- Malabsorptive conditions
- Chronic liver disease
- Certain rheumatological conditions
What is the most common type of hip fracture?
- NOF fracture
In what regions can a NOF fracture occur in?
- From subcapital region of femoral head to 5cm distal to lesser trochanter
What is an intra-capsular NOF fracture?
- From subcapital region to basocervical region of neck
What are the two types of extra capsular fracture?
- Inter-trochanteric
- Sub-trochanteric
How are NOF fractures graded?
- Garden classification
What are the different grades in the garden classification?
1 - Incomplete, undisplaced
2 - Complete, undisplaced
3 - Complete, partial displaced
4 - Complete, fully displaced
What is the gold standard investigation for suspected NOF fractures?
- Plain film radiograph
- AP and lateral
What radiological feature can be used as a reference for a NOF fracture?
- Shenton’s line
What blood test should be done in suspected NOF fractures?
- CK blood test
- To assess for rhabdomyolysis
What are the three parts of surgical intervention care?
- Pre-operative
- Peri-operative
- Post-operative
What are the aims of the a peri-operative assessment?
- Identification of significant co-mobidities
- 2-4 weeks before surgery
What are the two main parts of a pre-operative assessment?
- Full general examination
- Anaesthetic examination
What are the blood tests conducted as part of a pre-operative assessment?
- FBC
- U&E
- LFT’s
- Clotting profile
What cardiac investigations are undertaken in a pre-operative assessment?
- ECG
- ECHO
- Myocardial perfusion scans
What respiratory investigations are used in a pre-operative assessment?
- Spirometry in chronic conditions
- CXR
What other investigations are undertaken in a pre-operative assessment?
- Urinalysis
- MRSA swabs
- CPET (Cardiopulmonary exercise testing)
What are main principles of peri-operative management?
- Anaesthesia
- Pain relief
What are the principles of anaesthesia?
- Hypnosis
- Analgesia
- Muscle relaxation
What is the main goal of anaesthesia?
- Involves the loss of feeling or sensation
What are the different type of anaesthesia?
- General - Propofol IV
- Regional
- Conscious
What are the different types of regional anaesthesia?
- Neuroaxial - Epidural/Spinal
- Peripheral - Nerve block
What is the main aim of analgesia in peri-operative care?
- Loss of nociception/pain response