2024 POI Guidelines

Question 1

What nucleotide repeats make up the mutation for Fragile X ?

Answer 1

CGG

Question 2

What is the normal number of nucleotide repeats at the FMR1 gene locus

Answer 2

Less than 55

Question 3

How many repeats are in the premutation for fragile X

Answer 3

Between 55 and 200

Question 4

21-hydroxylase autoantibodies (21OH-Abs)
should be
performed in women with POI of unknown cause. Why is this

Answer 4

These antibodies are associated with auto immune Addisons disease which is where the immune system attacks the 21 hydroxylase enzyme, which ruins cortisol and aldosterone synthesis, but it I also associated with polyglandular autoimmune syndrome, which does what it says on the tin.

Question 5

Assessment of thyroid function should be done with (1) and repeated every (2) years, or when symptoms arise.

Answer 5

1. TSH
2. 5

Question 6

What is the average age of menopause in the UK

Answer 6

51