2016 Mock Exam

Question 1

1. Which of the following toxins reaches its target cell using retrograde axonal transport?
   a. tetanospasmin
   b. botulinum toxin
   c. syntaxin
   d. SNAP-25

Answer 1

a. tetanospasmin

Question 2

2. All of the following EXCEPT which are true regarding high mobility group box protein 1 (HMGB-1)?
   a. it is a histone-related nuclear protein
   b. it is an alarmin
   c. it can bind TLR2
   d. can cause release of IL-1

Question 3

3. Which of the following is present in neutrophil specific granules?
   a. acid hydrolases
   b. alkaline phosphatase
   c. elastase
   d. cationic proteins

Answer 3

b. alkaline phosphatase

Question 4

4. Which of the following occurs under hypoxic conditions?
   a. hydroxylation of HIF-α
   b. HIF-α binds von Hippel-Lindau protein
   c. HIF-α binds p300BP
   d. HIF-α is ubiquinated