2016 Flashcards
what are the predisposing factors of oral candidosis?
- prolonged antibiotic use
- poor oral hygiene
- denture wearer
- immunocompromised
- diabetes
- dialysis
- burn unit patient
what are the virulence factors of candida albicans?
- phospholipase contributes to host cell penetration
- haemolysin facilitates hyphal invasion
- proteinase aids in adhesion to epithelial cells
what infections can be caused by candida?
- periodontitis
- denture stomatitis
- UTIs
- endocarditis
what classification of oral candidosis is shown here?
pseudomembranous
what classification of oral candidosis is shown here?
chronic hyperplastic
what classification of oral candidosis is shown here?
angular chelitis
what are the 3 types of erthematous candidosis?
newtons type 1- localised inflammation
newtons type 2- diffuse inflammation
newtons type 3- granular inflammation
what are the signs and symptoms of denture induced stomatitis?
- inflamed mucosa, particularly under upper denture
- burning sensation
- discomfort
- bad taste
name 4 types of candida species
- albicans
- glabrata
- parasilosis
- tropicalis
how is denture stomatitis diagnosed in the lab?
- smear test / microscopy
- swab /culture on sabouraud’s agar / germ tube formation
angular cheilitis and acute pseudomembranous candidosis also the same
what are the 3 types of antifungal therapy?
- echinocandins
- azoles- fluconazole
- polyenes
how would you treat denture stomatitis in an immunocomprosed patient?
- systemic antifungal- fluconazole
- topical antifungal (nystatin)/ chlorhexidine rinse
how would you treat an oral fungal infection in a patient with poor oral hygiene?
- need to improve oral hygiene first
- chlorhexidine rinse
how would you treat an oral fungal infection in a patient with dry mouth?
topical antifungal e.g. nystatin
avoid systemic antifungals
how would you treat an oral fungal infection in a patient with large erosive lesions?
same as an immunocompromised patient
systemic antifungal with either topical antifungal or chlorhexidine rinse
give an example of an azole (antifungal medication)
fluconazole
give an example of a polyene (antifungal medication)
nystatin
give an example of an echinocandin (antifungal medication)
micofungin
what is the drug action of flucanazole?
interupts conversion of lanosterol to ergosterol by interacting with the enzyme which catalyses the conversion which stops formation of fungal membrane
what is the drug action of nystatin?
binds to sterols in plasma membrane of fungi, causing cells to leak
this causes fungal cell death
what are the four key design elements of randomised control trials?
- specification of participants
- control/comparison groups
- randomisation
- blinding/masking
name an advantage of randomised control trials
provide the strongest and most direct epidemiologic evidence for causality
give disadvantages of randomised control trials
- more difficult to design and conduct than oberservational studies
- not suitable for all research questions
- high costs
- still some risk of bias
what is a cross-sectional study?
observational study that analyses data collected from a population, or a representative subset, at a specific point in time
what is a case-series report?
description of the medical history of one or more patients
what is a case-control study?
people with a disease are matched to those without it and earlier exposure to different factors are compared
what is a cohort study?
participants are recruited to a study and followed up over time. Exposures and diseases are measured prospectively
what is a systematic review and meta analysis?
all the evidence for RCTs looking at effectiveness of a particular treatment are synthesised
what are case-series reports used for?
- hypothesis generation
- to identify a new disease outcome
what are the disadvantages of case series reports?
- cannot demostrate valid statistical associations
- lack of control group
what are cross sectional studies used for?
- estimating prevalence of a disease
- to investigate potential risk factors
what are the disadvantages of cross-sectional studies?
- recall bias
- causality
- confounding factors
what are case-control studies used for?
looking at potential causes of a disease
what are the disadvantages of case-control studies?
- confounding factors
- recall/selection bias
- time relationships (did exposure occur before disease)
what are cohort studies used for?
- estimating incidence of disease
- investigating cause of disease
- determining prognosis
- timing and direction of events
what are disadvantages of cohort studies?
- controls are difficult to identify
- confounding factors
- blinding is difficult
- need large samples for rare diseases
- very expensive and time consuming
what does a confidence interval do?
tells us the range of values that a true population treatment effect is likely to lie
what does a confidence interval that overlaps the value of no difference between treatments indicate?
there is insufficient evidence for a difference. between the treatment and control group in the population
what does it mean if the confidence interval overlaps 1?
there is insufficient evidence that there is a difference between the drug and the placebo
what is the absolute risk difference?
the difference in risk between groups
what is the value of no difference?
when there is no absolute risk difference
what is the ‘number needed to treat’ (NNT)?
the number of patients you would need to treat to prevent one patient from developing the disease/condition/outcome
what is the risk ratio?
number of events of interest/
total number of observations
what is the odds ratio?
number of events of interest/
number without the event
what are the principles of waste disposal?
- segregation
- storage
- disposal
- documentation
name 3 regulations for waste disposal
- the controlled waste regulations 2012
- the hazardous waste directive 2011
- the environmental protection act 1990