2015 - 5th Flashcards
These findings were obtained from a patient who was admitted to the ICU with septic shock: WBC: 40 (high); Hb:105 (low); Platelets: 25 (low); PT: 20 (high); APTT: 60 (high); TT: 20 (high); D- dimer: 4000 (high); FDP: 1.1 (high). What is the most appropriate management for this patient?
a. Treat the underlying infection
b. Fresh frozen plasma infusion
c. Anticoagulation with heparin
d. Packed RBCs transfusion
a. Treat the underlying infection
Note: Patient has DIC, the most important step is to fix the underlying cause.
A 48-year-old heavy smoker was admitted to the hospital with anterior MI from which he was recovering. One week later he experienced severe lower leg pain. It was pale, cold, and puseless. What is the cause?
A. cerebral embolism
B. arterial embolism
C. deep venous thrombosis
D. peripheral vascular disease
B. arterial embolism
First, deep vein thrombosis is characterized by the following:
1)Cause: Virchow triad (endothelial injury ‚venous stasis, hypercoagulability) gives rise to venous thrombosis.
2)Classic findings (all have low sensitivity and specificity):
-Low extremity pain and swelling (worse with dependency/walking, better with elevation and rest).
-Homans sign(calf pain on ankle dorsiflexion).
-Palpable cord.
-Fever.
What is the difference between peripheral vascular disease and acute arterial occlusion(embolism):
A 75-year-old patient came for his regular checkup. His lab test values were as follows:
Hb 146 (normal)
MCV 90 (normal)
WBC 52x10^9 (very high)
Platelets 257 (normal)
Lymphocytes 80% of total WBC, most were smudge cells What is the most possible complication?
a. Autoimmune hemolytic anemia
b. Polycythemia vera
a. Autoimmune hemolytic anemia
A diabetic and hypertensive patient presents with chest pain upon walking and climbing stairs specially after food. The pain has been there for two weeks but becoming more severe in the past two days. What is the most likely diagnosis?
A. Diffuse esophageal spasm
b. Unstable angina
C. Vasospastic angina
b. Unstable angina
what is the most sensitive indicator of contrast-induced nephropathy?
a. urine output < 600
b. hematuria
c. rising creatinine > 26 in 24 hours
c. rising creatinine > 26 in 24 hours
A patient presented with painless lymphadenopathy. He also had weight loss and night sweats. What is the diagnosis?
a. Hodgkin’s lymphoma
b. Non-hodgkin’s disease
c. Infectious mononucleosis
d. Thyroid cancer
a. Hodgkin’s lymphoma
A patient with the history of valvular heart disease presents with this ECG. What do you give to prevent disabling neurological damage?
A. Beta blockers
B. Warfarin
C. Aspirin
B. Warfarin
Anticoagulants should be used with atrial fibrillation to prevent thromboembolism. The large left atrium predisposes to atrial fibrillation, giving rise to symptoms such as palpitations. Atrial fibrillation may result in systemic emboli, most commonly in cerebral vessels, producing neurological sequelae, but mesenteric, renal, and peripheral emboli are also seen, so anticoagulant should be used to prevent thromboembolism.
25 years old Kuwaiti woman, history of continuous productive cough at childhood. Admitted to the hospital several times during childhood for recurrent dyspnea, cough, and fever. Increased symptoms the last 1 month. On physical examination, somewhat tachypneic, localized crackles in left lower zone, and bilateral rhonchi.
What is the diagnosis that explains the above?
A. Bronchiectasis
B. Acute exacerbating of asthma
C. Pneumonia
D. Congenital emphysema
A. Bronchiectasis
A patient with progressive right-side hearing loss. Upon Weber test he heard louder on the left side. What is his condition?
A. Left conductive deafness
B. Right sensorineural defenses
C. Right conductive deafness
D. Left sensorineural deafness
B- Right sensorineural defenses
A patient with T2DM and ESRD presenting to the ER with a fever of 38. He was found to have right lower lobe pneumonia. Sodium is 123, glucose is 60, and PH is 7.38. Which of the followingis true? (I think urea is missing?)
A. He is in DKA
B. He is in a hyperosmolar state
C. The cause of his hyponatremia is due to osmotically-active glucose-mediated diuresis
D. He has a high osmolal gap
B. He is in a hyperosmolar state
A patient presented to the clinic with gait instability, he cannot walk keeping his heel touching his toe, what does he have?
Cerebellar ataxia (gait ataxia?)
A patient with blisters on the face (shingles) (they didn’t say where exactly on the face), what nerve is hurt?
A. Facial
B. Trigeminal
B. Trigeminal
A type 2 diabetic patient is on metformin and statins, he however now has high triglycerides despite being on statins. What should be given to him?
A. Fenofibrate
B. Clofibrate
C. Gemfibrozil
D. Omega 3
Answer: B. Clofibrate (most likely, not 100% sure)
Note: Gemfibrozil increases blood levels of repaglinide (Prandin) in people with diabetes, increasing the likelihood of developing low blood sugar (hypoglycemia). This combination should be avoided.
A young patient spontaneously had golden crusted painful lesions in upper lip chin and nasolabial folds. Also had fever. What is the most common organism cause if this condition worldwide?
A. Staphylococcal aureus
B. Streptococcus pyogenes
C. Staphylococcus epidermis
B. Streptococcus pyogenes
(this is impetigo)
A patient with long arm and hands with a diastolic murmur what will you find on examination?
A. Pulses bisternis or alterntis
B. Collapsing pulse
B. Collapsing pulse
(aortic regurgitation in patients with marfans syndrome)
What is the best time for the patient to take omeprazole if once daily regimen?
A) before bedtime
B) before breakfast
C) before lunch time
D) before dinner
B) before breakfast
A patient is having tonic-clonic seizure, after 10 minutes he is still in the seizure. How will you manage?
A. Brain CT
B. Electroencephalogram
C. Administer IV phenytoin
D. Carbamazepine
C. Administer IV phenytoin
(Carbamazepine does not have a role in treating status epilepticus)
A patient with chronic pancreatitis presented with steatorrhea. He is a smoker and an alcohol drinker. How would you treat him?
A. Insulin
B. Pancreatic enzymes replacement
B. Pancreatic enzymes replacement
A patient underwent subtotal thyroidectomy and was given levothyroxine. Came in later with palpitations and TSH was found low. how to manage?
A. Lower the dose
B. Leave the dose
A. Lower the dose
A patient with beta thalassemia major, hypopituitarism, infertility, and dark skin. What is your management for this patient?
a. iron chelating therapy
b. bone marrow transplantation
c. wait and re-evaluate approach / wait for one year
d. reduce amount of transfusions
a. iron chelating therapy
A female patient who is a known case of rheumatoid arthritis and given both her RF and anti-citrullinated antibodies are high. Which of the following is not one of the extra manifestations of the disease?
A. Amyloidosis
B. lung fibrosis
C. myositis
D. entrapment neuropathy
C. myositis (the musculoskeletal extra manifestation are: tenosynovitis, bursitis, and carpal tunnel. myositis is not one of them)
Which of the following cannot be obtained from a spirometer?
A. Inspiratory capacity
B. Expiratory reserve volume
C. Functional residual capacity
C. Functional residual capacity
A 23 year old female with polyarticular joint pain for the past 2 months. Which of the following suggesting inflammatory arthritis?
A. morning stiffness less than 15 min
B. fatigue
C. pain worse with movement
D. weight gain
B. fatigue
Which is a characteristic of ulcerative colitis and not Crohn’s?
A- rectal involvement
B- Segmental involvement
C- Granuloma at biopsy
D- Palpable abdominal mass
A- rectal involvement
A patient underwent an aortic valve replacement with St. Jude mechanical valve as he had rheumatic heart disease. No postoperative complications seen. Now he must be discharged. What do vou give him as a lifelong treatment?
A. Clopidogrel
B. Warfarin and aspirin
C. Dabigatran
D. Rivaroxaban
B. Warfarin and aspirin
-Both Dabigatran and Rivaroxaban are contraindicated in mechanical heart valve.
A patient had a stroke and developed weakness of the right side (face and arms) and right homonymous hemianopia and disturbed speech. Which arterial territory is affected?
A- Left middle cerebral artery
B- Posterior cerebral artery
C- Posterior inferior cerebellar artery
D- Anterior choroidal artery
A- Left middle cerebral artery
(MCA stroke symptoms: unilateral weakness and/or numbness, facial droop, and speech deficits ranging from mild dysarthria and mild aphasia to global aphasia.)
(Posterior circulation strokes commonly present with symptoms of altered mental status, vision changes, speech changes, nystagmus, vertigo, ataxia, limb weakness, headache.)
Patient with fibrosis involving upper zones of the lung predominates. What is the most likely diagnosis?
A. IPF
B. Asbestosis
C. Sarcoidosis
D. Scleroderma
C. sarcoidosis
(bilateral lymphadenopathy and infiltrate in the mid upper zones are characteristic of sarcoidosis.)
25-year-old female with SLE, presented with anemia, jaundice, dark urine, high reticulocytes, high LDH.
A. Liver cell failure
B. Autoimmune hemolytic anemia
C. Paroxysmal nocturnal hemoglobinuria
D. Thalassemia major
B. Autoimmune hemolytic anemia
Which of the following microbial infections is associated with eosinophilia (or esoniphiluria)?
A. Treponema Palladium
B. Streptococcus Pneumonia
C. Cryptococcus Neoformans
D. Strongyloides Stercoralis
D. Strongyloides Stercoralis
A patient with symmetrical joint narrowing and suspected rheumatoid arthritis. How to detect Rheumatoid factor?
A. Nephelometey
B. Flow cytometry
C. ELISA
D. Immunoflurocence
A. Nephelometey
A pair of newlyweds took a premarital screening test for inherited blood disorders, one of them has sickle cell trait and the other has thalassemia trait. Which of the following statement is true?
a. There is 25% that their children will have thalassemia major
b. There is 25% that their children will have thalassemia trait
c. All their children will have thalassemia/sickle disease
d. All their children will have abnormal genes
b. There is 25% that their children will have thalassemia trait
A blood film report came mentioning the presence of “howel-jolly bodies”. What does thid finding indicate?
a. autoimmune hemolytic anemia
b. splenomegaly
c. splenectomy
d. liver cell failure
c. splenectomy
A 70-year-old patient came with progressive cough and shortness of breath, no other abnormalities, and no past medical history. What is true about diagnosis of IPF?
A. HRCT scan can diagnose IPF with confidence
B. Bronchioalveolar lavage and biopsy is needed for diagnosis
A. HRCT scan can diagnose IPF with confidence
A 35-year old lady who works as a secretary, presented with productive cough and low-grade fever. Physical examination showed clubbing, febrile 37.5 c, BP 110/70. Cardiovascular and abdominal examination were unremarkable. On chest examination, coarse crackles were heard in left axillary base and right posterior base. As a teenager, she experienced recurring bouts of productive cough that worsened over the years, but she ignored following up with her GP. What is the best test to diagnose her condition?
A. Bronchoscope and lavage
B. Throat swab
C. High Resolution CT scan
C. High Resolution CT scan
Note: HRCT is gold standard diagnosis of bronchiectasis
A patient was taking lamotrigine. Two weeks later he developed a scaling rash. what is true about this condition? (there was a picture in black and white —> toxic epidermal necrolysis from the picture)
A. Patients develop conjunctivitis and corneal ulceration
B. Patients should get a skin prick test as they are allergic to this drug
C. Patients have an infection with EBV
D. Patients have antibodies against desmoglein 1 and 3
A. Patients develop conjunctivitis and corneal ulceration
A patient was admitted to the hospital with sudden onset of chest pain. ECG was shown (Inferior MI). Which artery is affected?
A. Right coronary artery
B. Left anterior descending coronary artery
C. Left circumflex artery
A. Right coronary artery
Areas of infraction/ischemia:
A 30-year-old patient presented with itchy skin, scaly excoriation on trunk, scattered papules, few pustules on body but face is spared. Nodules on scrotum and linear rashes all over the body. What is a secondary finding?
A. Excoriation
B. Vesicle
C. Papule
D. Pustule
A. Excoriation (secondary means due to the primary lesions being itchy, there are
excoriation marks due to the scratching, this scenario likely depicts scabies)
A 30-year-old patient presented with hypertension. Urinalysis showed microscopic hematuria. 24 hour urine protein collection revealed protein 0.75 mg. complement levels were normal. what is the most likely diagnosis?
a. SLE
b. IgA nephropathy
c. post-strept GN
d. membranous GN
b. IgA nephropathy
Patient presents with weight loss you suspect diabetes type 1 which will confirm the diagnosis?
A. fasting plasma glucose 6.5
B. fasting plasma glucose 7.5
C. random glucose 10.5
D. plasma glucose 10 mmol after OGTT
B. fasting plasma glucose 7.5
Note: if the potassium is LOW or NORMAL we either fix the abnormality or give prophylactic KCL because the insulin will definitely lower the potassium. We only refrain from KCL infusion when the potassium is high before starting NS
A pregnant lady presents with fever and cough. On examination, there is consolidation in the right lower zone. What is the diagnosis?
A. Asthma
B. Pneumonia
B. Pneumonia
A patient presented with unilateral miosis and ptosis. He has a history of tackle in American football. What is the diagnosis?
A. Horner syndrome
B. Myasthenia gravis
C. Third nerve palsy
A. Horner syndrome
• Horner syndrome causes unilateral miosis and ptosis
• Myasthenia gravis doesn’t affect pupils
• 3rd n. palsy causes ptosis and mydriasis (pupils dilation).
A 25-year-old female, hypertensive on hydralazine, presented with joint pain. Labs show ANA+ anti histone positive, negative dsDNS. What is the most appropriate management?
A. Stop hydralazine
B. Start azathioprine
A. Stop hydralazine ( a mnemonic for drug induced lupus My Two HIPS: methyledopa, TNA-alpha inhibitors, Hydralazine, Isoniazid, Procanamide/Phenytoin, Sulfa drugs)
A 32 years old male, who has stress at work, presents with diarrhea relived by defecation. He
underwent a colonoscopy, which showed multiple diverticulosis otherwise normal mucosa. He went back to work after the appointment and had abdominal pain relieved by defecation. What is the diagnosis?
A. Diverticulitis
B. Irritable bowel syndrome
B. Irritable bowel syndrome
Bloating, constipation and abdominal pain that is relieved by defecating is IBS. IBS is associated with a normal colon on colonoscopy, and is mainly induced by stress.
A tall female, with mid-systolic click and a late systolic murmur. What is the most likely finding on echo?
A. Myxomatous degeneration of mitral valve
B. Thick intersental wall
C. Calcified aortic valves
A. Myxomatous degeneration o mitral valve
Mid systolic click and late systolic murmur >Mitral valve prolapse
A patient with psoriasis. What is an extra musculoskeletal manifestation? (there was a scenario indicating psoriasis scaly erythematous rash and polyarticular joint?)
A. Dactylitis
B. Heberden nodes
C. Bochard nodes
D. Subcutaneous nodules
A. Dactylitis ( all of the others are not in psoriasis and please check the extra manifestation of psoriasis)
A lesion (1 or more than one cm) raised, flat, solid with length more than depth?
A. Papule
B. Nodule
C. Patch
D. Plaque
D. Plaque
A healthy 35-year-old male presented with indigestion and retrosternal heartburn. No alarm symptoms. Labs within normal limits. Which of the following is most proper initial step?
A) Empiric trial of PPI
B) Esophageal manometry
C) Non-invasive H. Pylori tests
D) Upper GI endoscopy.
A) Empiric trial of PPI
Indigestion and retrosternal heartburn indicate GERD. GERD is mainly a clinical diagnosis, a trial of PPIs for two weeks with patient response is usually sufficient to make a diagnosis.
23-year-old woman admitted with lobar pneumonia. she was given IV ampicillin and gentamicin. she also had a CT with contrast on the first day. one the 4th day her serum creatinine was normal. On the 8th day her serum creatinine was 250. what is the main cause of her AKI?
a. Sepsis due to pneumonia
b. Gentamicin
c. Contrast
d. AIN
b. Gentamicin
The effect of gentamicin starts in the second week
A 27-year-old female had a left sided unilateral throbbing headache associated with nausea, vomiting, and years ago, she experienced similar episode. how would you treat her?
Sumatriptan
What is true about antibodies?
A. IgM antibodies form a dimer in the blood
B. IgG and IgA antibodies can cross the placenta
C. Ig’s can only have a single light chain kappa or lambda
D. During infection, IgG appears first in the blood then IgM
C. Ig’s can only have a single light chain kappa or lambda
A 37-year old smoker (30 pack years) presented with dyspnea that is worsening. Chest x- ray is significant for heterogeneous translucency of both upper and lower lobes and flattened diaphragm. Which test is helpful?
A. Leptin
B. alpha 1 anti-trypsin level
C. ghrelin level
D. protease level
B. alpha 1 anti-trypsin level
Patient with sickle cell disease and presented with signs/symptoms of pancytopenia and big spleen. What is the diagnosis?
splenic sequestration crisis
Which of the following supports the diagnosis of bacterial meningitis?
A. Normal glucose levels in CSF
B. High lymphocyte count
C. Negative gram stain
D. WBC > 2000
D. WBC > 2000
51 y/o Female with moderate to severe headache and photophobia, her mother is migraineur. Which of the following raises suspicion of secondary headache?
A. moderately to severe headache
B. photophobia
C. age after 50
D. family history
C. age after 50
Red flags for secondary headaches: SNOOP4
• Systemic signs and symptoms
• Neurological finding on examination
• Older than 50 y/o
• Onset sudden
• Postural headache
• Precipitated by valsava, cough, or sneeze
• Progression of headache
• Presence of papilledema
a 61-year-old patient had low urine output one day after coronary angiography. What will be a characteristic finding in urine?
a. Eosinophiluria
b. proteinuria 2.5
c. urine with high osmolarity
c. urine with high osmolarity
Patient was diagnosed with MS and was found to have oligoclonal bands in CSF, what are oligoclonal bands?
A. immunoglobulins in CSF
A female presents with one-week history of abdominal pain and vomiting. Her serum creatinine is found to be 150. What is your next step of management?
a. CT with contrast to diagnose the cause
b. IV fluid infusion
b. IV fluid infusion
The patient had dehydration!
Which of the following conditions increases the risk of having carcinoma of the colon?
A. Diverticular colitis
B. Ischemic colitis
C. Microscopic colitis
D. Ulcerative colitis
D. Ulcerative colitis
Which part of the skin is absent in the lesional skin of psoriasis?
A. Stratum Corneum
B. Stratum Spinosum
C. Stratum Basale
D. Stratum Granulosum
D. Stratum Granulosum