2012 - 5th Flashcards

1
Q

Patient had a surgery to repair his heart’s septal defect. After surgery he developed salpitations, tachycardia, etc. What is the most likely diagnosis?

A

open cardiac syndrome or something like that

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2
Q

What is found in primary ovarian failure?

A

A. high FSH / low estradiol/ normal prolactin

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3
Q

A patient came with alopecia, and other extra articular manifestation (mouth ulcer etc.) what will be positive in this case?

A

Anti-nuclear antibodies (suspecting SLE)

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4
Q

Which is true about contrast dye in a renal impaired patient?
a. likely to cause irreversible kidney damage
b. takes 2 weeks for the adverse effects to develop

A

a. likely to cause irreversible kidney damage
* An irreversible decline in kidney function after recovery is more likely in patients over age 65 years, lower baseline GFR, hypoalbuminemia, and comorbidities including hypertension and heart failure “up-to-date” (2012 Tafree’3)

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5
Q

Right Ear hearing loss, weber’s test shows lateralization to right ear, rinne’s test on the right ear shows bone conduction > air conduction and left ear showing air conduction superior to it. What’s the likely diagnosis?
A. Right Ear hearing Conductive loss
B. Right ear sensorineural loss

A

A. Right Ear hearing Conductive loss

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6
Q

A 68 yr old man presented with hemoptysis and rapidly progressive renal failure, his biopsy showed anti GBM antibodies with linear deposition on immunofluorescence, what’s the most likely dx:
Good pasture syndrome
Post streptococcal
Wagner’s granulomatosis
Lupus nephritis

A

Good pasture syndrome

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7
Q

Female gets diplopia after reading for 10 minutes, and muscle weakness after climbing stairs, she is completely normal at rest. What test helps in the diagnosis?

A

Tesilon test (edrophonium) or serum Anti-AChR or nerve stimulation test

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8
Q

Patient with severe headache (11/10). When asked about photophobia he answered yes. He can’t sit still, and walks back and forth.
A. tension headache
B. migraine
C. subarachnoid hemorrhage D. cluster headache

A

?
assuming that the patient CAN’T sit still

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9
Q

A case with PMN > 600

A

SBP (maybe) (spontaneous bacterial peritonitis)
Neutrophil count > 250 cells/mm3 = SBP

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10
Q

68-year-old patient with chronic kidney disease about to undergo dialysis. What can you
tell him about dialysis?

A

Peritoneal dialysis is chosen treatment in Chronic Heart Disease
since hemodialysis can cause cardiovascular stress

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11
Q

A patient with asymmetrical hypertrophy and MR?
a. pulses alternates
b. pulses paradoxical
c. pulses bigiminus

A

a. pulses alternates

I think this question is missing more details, but:
Pulsus alternans:
-It is characterized by beat to beat variability of the arterial pressure waveform.
-It occurs most commonly in heart failure due to increased resistance to LV ejection,as occurs in hypertension,aortic stenosis, coronary atherosclerosis ,and dilated cardiomyopathy.
Pulsus paradoxus:
-It is characterized by exaggerated fall in patient’s blood pressure during inspiration by greater than 10 mmHg(normally should be less than 10).
-It is often due to pericardial disease ,particularly cardiac tamponade and to a lesser degree constrictive pericarditis.
Pulsus bigeminus:
-It is characterized by groups of two heart beats closed together followed by a longer pause .The second pulse is weaker than the first.
-The most common cause of pulsus bigeminus is hypertrophic obstructive cardiomyopathy.
Note:
-there is many types of HCM ,and one of these types is asymmetrical septal hypertrophy with obstruction which can lead to
MR(I think the previous question is about this type, but more details is needed ).so for me the answer is pulsus bigeminus.
-If the question mentioned AS rather than MR with signs of heart failure ,it is most probably pulsus alternans.
The following article explains the association between HOCM and MR:

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12
Q

A 31-year-old previously healthy woman with no past medical history presents with anxiety, insomnia, heat intolerance and new onset atrial fibrillation. Which of the following would explain the patient’s symptoms?
A. TSH is abnormally high
B. TSH is abnormally low
C. The patient has unexplained weight gain
D. The patient’s symptoms are due to panic attack
E. The patient’s symptoms are due to type IV hypersensitivity reaction

A

B. TSH is abnormally low

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13
Q

Patient with severe headache, photophobia, intolerance to sound. A. migraine without aura
B. migraine with aura C. cluster headache D. tension headache

A

A. migraine without aura
*the question didn’t mention anything about preceding symptoms (Aura)

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14
Q

Question about paralysis and sensory loss at umbilicus what level?

A

T10

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15
Q

50-year-old female with retrosternal chest pain after eating with bitter taste. No difficulty or pain while swallowing. What is the best investigation to evaluate the etiology of her symptoms? a. 24 hr esophageal pH.

A

*GERD is a clinical diagnosis based on response to PPI. Endoscopy has specific indications (failure of response to PPI or alarming symptoms). If endoscopy is normal and diagnosis is still questioned, 24hr pH monitor & esophageal manometry are used.

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16
Q

5-year-old with facial dropping, can’t maintain puffed cheeks, has flat nasolabial folds, left eye closure is slightly weaker than right eye. Where is the lesion?

A

*he has complete lower face paralysis and slightly upper face paralysis left-sided lower motor lesion of the facial nerve

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17
Q

A patient presented with anaphylactic shock after eating peanuts. What would give
him?
A. Epinephrine
B. Propranolol

A

A. Epinephrine

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18
Q

Q4. A hypertensive patient regularly taking his medication developed pedal edema. What’s the name of the drug?

A

a. Ca channel blocker
*“-dipines”

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19
Q

A young woman who is tall and lean with short anterior diameter of the chest with occasional palpitations was diagnosed with mitral regurgitation with anterior and posterior valve prolapsed. What is the best management?
a. Mitral valve replacement
b. Beta-blockers

A

b. Beta-blockers

-The previous question describes features of Marfan’s syndrome and it is associated with myxomatous degeneration that leads to mitral prolapse and can prognose to mitral regurgitation in some cases.
- in the case of mitral prolapse, if the patient is:
1)Asymptomatic:no treatment reassurance.
2)Symptomatic:B blocker and avoidance of stimulants(caffeine) for significa : palpitation, anticoagulants if Afib.
3)surgical treatment is only indicated if symptomatic and significant MR, and mitral repair is favored over replacement.
Note:Advantage of repair over replacement:low rate of endocarditis,no anticoagulation is needed ,and less chance of re-operation.
Indications of mitral valve replacement(patients who are not good candidate for percutaneous ballon valvotomy and mitral valve repair who are:
1)Moderate to severe MS and NYHA class 3-4
Z)severe MS (mitral valve area <lcm) and severe pulmonary HI (pulmonary artery systolic pressure >60 mmlig,
Bisevere mira stenosis who are underooino suroerv for another reason.
A severe MS who would have been candidates for valotomy but have contraindications to the procedure
brecurrent thromboembolic exisodes despite anficooulation in coniunction with mitra stenosis

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20
Q

A patient came to the clinic complaining from a unilateral headache. She said when it comes she can’t tolerate loud sounds, TV, and become sensitive to lights. She can’t know when it will come.
A. Migraine with aura
B. Migraine without aura C. Cluster
D. Tension headache

A

B. Migraine without aura

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21
Q

A patient had hemoptysis and hematuria (a wegner granumalatosis case). What will be positive?

A

c-ANCA

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22
Q

A patient with signs and symptoms of UC is at risk of what disease?

A

sclerosing cholangitis

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23
Q

Patient with autoimmune disease heard that some autoimmune diseases can
predispose to cancer. What can you tell her about this?
A. Rheumatoid Arthritis can cause lymphoma
B. Pernicious anemia with leukemia
C. Good pasture with lung cancer

A

A. Rheumatoid Arthritis can cause lymphoma

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24
Q

A female with arrhythmia. which drug can work on slow Ca channel?
a. Varapamil
b. Adensine
c. Amiodarone
d. Phenvtoin

A

a. Varapamil

  • Verapamil is a class 4 antiarrhythmic drug which works as a calcium channel blocker -> slows phase 4 spontaneous depolarization -> slows AV conduction.
    -Adenosine is an adenosine receptor agonist.
  • Amiodarone is a class 3 antiarrhythmic drug ,which works by blocking potassium channel -> prolongs phase 3 reporalization -> prolongs refractory period.
    -Phenytoin is an anticonvulsant ,which work as NA channel blocker.
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25
Q

Which substance is food for the small bowl?

A

glutamine

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26
Q

A patient came with UGIB. You did the ABC and resuscitated him. On endoscopy you saw varices with stigma of recent bleeding. What’s the most appropriate next step?
a. IV omeprazole
b. Band ligation
c. TIPS
d. Balloon tamponade

A

b. Band ligation
How to approach upper GI bleed (stepwise): 1) if varices- iv octreotide and iv antibiotics, if PUD- iv ppi 2) Esophageal banding 3) if banding fails, insert a Sengstaken-blakemore tube 4) followed by emergent TIPS 5) to prevent further bleeding, give beta blockers.

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27
Q

A question about Child Pugh

A

?

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28
Q

patient having hyponatremia + high serum osmolality:
Hyperglycemia
Hyperlipiddmia
SIADH

A

Hyperglycemia
*hyperlipidemia causes pseudohyponaterima, however, plasma osmolality would be normal. On the other hand, hyperglycemia increases plasma osmolality and decreases sodium through osmotic diuresis.

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29
Q

A female with jaundice, nausea, and anorexia recently traveled to Syria and has no drug history. ALT & AST are very high (thousands), Bil and ALP elevated, PT normal. What antibody would you find?

A

HAV IgM
Clinical picture of jaundice, nausea, and anorexia indicates hepatitis. Elevated ALT and AST
indicates a hepatocellular injury which is usually found in hepatitis. Nothing in the stem
indicates a parental/sexual/transfusion cause, therefore it has to be fecal-oral (either HAV or
HEV). Also a recent travel to Syria is more relevant with HAV.

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30
Q

A young patient had sudden pain in the upper back, few days later she developed vesicles with dermatomal distribution. What virus is this?
A. VZV
B. HSV

A

A. VZV

31
Q

A 36-year-old lady with 8 years old history of rheumatoid arthritis. X-ray of her hand shows erosions to metacarpophalangeal joint, what is the pathology behind it?

A

Pannus formation
*pannus, granulation tissue, is formed secondary inflammation initiated by immune complex deposition and cytokines. It is responsible for limited range of motion in the late stages due to ankyloses.

32
Q

A patient with psoriasis. What extra articular manifestation will prsent?

A

Nail pitting

33
Q

A patient on a medication for her illness showed anti-histone antibodies. What will you
do?

A

Stop the medication ( the medications mentioned above of drugs induced lupus)

34
Q

you give a hypertensive patient treatment. patient develops lower limb edema. what is the most likely agent?

A

calcium channel blocker

35
Q

Ceruplasmin high normal a. wilson’s disease
b. Hemochromatosis
c. Autoimmune hepatitis
d. Acute hepatitis

A

-

36
Q

A wife comes to you complaining that her 42-year-old husband is snoring in his sleep and his breath is interrupted. The husband denies his wife’s claims and says he’s feeling just fine. During work the husband is known for his sleepiness. Which one better explains the nature in this type of sleep apnea?
a. both nasal effort and respiratory efforts are reduced
b. the nasal effort is maintained while respiratory effort is reduced
c. the nasal effort is reduced while respiratory effort is maintained
d. there is no association between nasal and respiratory effort

A

c. the nasal effort is reduced while respiratory effort is maintained

The hallmark of OSA are the witnessed apneas (cessation of breathing) during sleep. It is associated with frequent loud snoring, restless sleep, nocturia, and excessive daytime sleepiness. Despite increasing breathing efforts, the upper airway collapse results in episodes of obstructive
hypopneas/ apneas. The breathing effort is still present, but the upper airway is collapsed.

37
Q

Case of PCOS. Which of the following is present?
A. Low Estrogen
B. Predisposes to DM
C. High levels of Testosterone
D. High prolactin
E. Increased FSH: LH ratio

A

B. Predisposes to DM

38
Q

patient underwent operation and is now oligouric. ultrasound shows bilateral hydronephrosis. patient also has resonant suprapubic mass. What is the initial treatment?

A

insert urinary catheter

39
Q

A patient came with dry cough, SOB, fine inspiratory crackles (ILD case). How to confirm your suspicion?
a. High resolution CT
b. Do the whole PFTs
c. Ventilation perfusion test
d. Bronchoscopy with biopsy

A

a. High resolution CT
HRCT is usually the key component of the diagnostic evaluation of ILD. Although bronchoscopy and/or surgical lung biopsy may be required to make a confident diagnosis of a specific ILD, it is not always necessarily done. HRCT can confidently exclude (rule out) an ILD diagnosis if it had no findings and so is therefore invaluable.

40
Q

A question about Methacholine challenge test

A

Asthma

41
Q

18 yr old girl presented with jaundice malaise. on examination she is confused and disoriented. PT 42s, ALT 3200. what is the appropriate initial investigation?

A

check serum paracetamol levels
Main cause of an acute fulminant liver is paracetamol. Young girl presenting with sudden symptoms of acute liver injury may be closely associated with paracetamol overdose.

42
Q

Extra articular manifestation of rheumatoid arthritis ?

A

pleural effusion

43
Q

A 57-year-old male with COPD treated with loop diuretics. pH 7.38 (normal), PCO2 9.9 kPa (high), PO2 6.9 kPa (low), PHCO3 53.8 mmol/l (high).
a. Normal acid base status
b. Simple respiratory acidosis
c. Simple metabolic alkalosis
d. Mixed respiratory acidosis and metabolic alkalosis

A

d. Mixed respiratory acidosis and metabolic alkalosis

44
Q

A nurse talking in the phone suddenly she pauses says 3 words then smacks her cheek then she says sorry i have to go and closes her phone?

A

Absence seizure
*incomplete choices for this question (not absence, maybe simple partial ?)

45
Q

A pregnant lady came from India with symptoms of hepatitis. Which agent is likely to cause her symptoms?
a. HBV
b. HCV
c. HAV
d. HEV

A

Clues indicating it is HEV: pregnant lady and a travel to India, which is relevant with the fecal oral route of transmission.

46
Q

Right eye constricts. Left eye constricts in return rt eye dilatation

A

Relative afferent nerve affects

47
Q

A secretary came for examination of carpal tunnel syndrome. He also complains from fatigue. What’s best for his management?
A. tinal test
B. Phalens test
C. Thyroid function test

A

C. Thyroid function test

48
Q

A 60-year-old patient came with burning chest pain that radiates to both sides of the chest and exacerbates when leaning forward. Where is it coming from?
a. Pancreas
b. Esophageal
c. Heart

A

b. Esophageal
Burning chest pain that radiates to both sides of the chest and exacerbates when leaning forward is indicative of GERD.

49
Q

A young female with chronic RA presents with bilateral flank pain and microscopic hematuria, she is on MTX and NSAIDs for many years!! Which of the following is consistent?
Bladder carcinoma
Chronic GN
Amyloidosis of kidney
Chronic tubulointerstitial nephritis
Papillary necrosis

A

Papillary necrosis
As chronic tubulointerstitial nephritis is usually asymptomatic and found incidentally (2012 Tafree’3)
My explanation: as NSAIDS lead to inhibition of prostaglandin- mediated vasodilation in the vasa recta -> causing ischemia -> necrosis and sloughing of the papillae will occur -> ureteral obstruction. Patient will present with flank pain, hematuria.
Causes of papillary necrosis: POSTCARDS: P: pyelonephritis, O: obstruction, S: sickle cell disease, T: tuberculosis, C: Cirrhosis, A: Analgesics (NSAIDS), R: Renal transplant rejection, D: DM, S: systemic vasculitis.

50
Q

A case presented with changed of bowel habits and everything else was normal.

A

IBS

51
Q

The antidote of unfractionated heparin?

A

protaminesulfate

52
Q

A 12-year-old boy known case of type 1 DM. He checks his blood glucose level once a month and think that he’s controlling it very well. How to know the level of glucose for the last 3 months?
A. HBA1c
B. Fasting blood glucose C. 2h OGTT

A

A. HBA1c

53
Q

PFT showing low FEV1/FVC with significant bronchodilator reversibility (dlco rv and tlc normal). What does the patient have?

A

Bronchial asthma
Answer: A
Bronchial asthma shows decreased FEV1 and FEV1/FVC ratio on PFT, that is reversible upon administering bronchodilators. (meaning that it results in an increase of at least 12%)

54
Q

What is true about the small cell carcinoma of the lung?
a. least associated with smoking among all lung cancers
b. Distant metastasis is common
c. Best for resection in comparison to other types
d. Better treated with radiation

A

b. Distant metastasis is common
SCLC tumors are usually nonresectable and quickly metastasize. Their prognosis is very poor, and chemotherapy is usually used alone as initial treatment.

55
Q

A middle age male presented with upper arm blood pressure 180/100 and lower limb 160/90. What is the diagnosis?

A

Coartication of aorta
Coarcatation of the aorta is characterized by HTN in the upper extremities with hypotension in lower extremities.
Another important feature is: Radio-Femoral delay

56
Q

patient with constipation have (RCC: renal cell carcinoma ) +bone metastasis and liver. What is the cause of his constipation?
a. hyperkalemia
b. hypercalcemia
c. hypoparathyroidism

A

b. hypercalcemia
hypercalcemia is a well-known paraneoplastic syndrome in renal cell carcinoma.

57
Q

Case of pancreatitis, what signifies bad prognosis?

A

low oxygen saturation
*check Ranson’s criteria

58
Q

A 38-year-old woman presented to the primary care physician for routine evaluation. She has no past medical history of disease. Physical examination revealed moist mucous membranes and no peripheral edema. Examination of the heart, lungs, GI were all normal. Lab investigations showed serum sodium of 126 (low) and serum osmolarity of 305 (high). What could explain the findings above?
a. Hyperglycemia
b. Hyperlipidemia
c. Nephrotic syndrome d. SIADH

A

a. Hyperglycemia
*hyperlipidemia causes pseudohyponaterima, however, plasma osmolality would be normal. On the other hand, hyperglycemia increases plasma osmolality and decreases sodium through osmotic diuresis.

59
Q

An 82-year-old female with uncontrolled COPD has an episode of exacerbation and is treated with IV cephalosporin. One week later she develops abdominal tenderness and intractable diarrhea. Sigmoidoscopy showed yellow discoloration on the mucosa of sigmoid and rectum. What is the diagnosis?
a. Pseudo-membranous colitis b. Crohn’s

A

a. Pseudo-membranous colitis
It occurs after taking antibiotics. Using antibiotics can cause the bacterium Clostridium difficile
(C. diff) to grow and infect the lining of the intestine (yellow discoloration on the mucosa),
which produces the inflammation.

60
Q

What is the diagnosis of a patient with the following labs?
Low Hb, high MCV, slightly elevated WBC, very low platelets, direct Coombs: negative and schistocytes are positive.

A

a. TTP

61
Q

60-year-old heavy smoker male with COPD. Which is true?

A

Long term oxygen therapy improves survival
Home oxygen therapy, along with smoking cessation, are the only two interventions shown to lower mortality. Vaccinations for Influenza and S. Pneumonae are also offered to all patients.

62
Q

patient with recurrent infection otitis media/pneumonia/hemophilis influenza, what is deficient in this patient?
A. Natural killer cell
B. Interferon
C. AIDs/HIV
D. Complement
E. Antibodies

A

E. Antibodies

63
Q

A 20-year-old male with 5-year history of psoriasis presented with pain and swelling of the heel for 2 weeks duration. Which of the following is a musculoskeletal manifestation of the disease?
A. Heberden nodes
B. Bouchard nodes
C. Squaring of 1st metacarpophalangeal joint
D. Enthesitis

A

D. Enthesitis

64
Q

A patient with red tender nodules on legs and shins with 3 weeks history of joint paint. The patient has an upper respiratory tract infection 6 weeks ago, mild leukocytosis and high ESR. What is the diagnosis?

A

Erythema nodosum. (most likely streptococcal infection in upper respiratory tract)

65
Q

A female patient came for cholecystectomy surgery. Her blood tests showed normal platelet count and prothrombin time. The APTT was prolonged.
What factor is deficient?
a.Fibrinogen
b.Factor X
c.Factor V
d.Von wilibrand factor
e. Factor VII

A

d.Von wilibrand factor

66
Q

Q about prolonged appt supposed to be factor 12 but no factor 12 in choices.

A

-

67
Q

They put a picture of reed Sternberg cells of Hodgkin lymphoma and the patient had the lumps in his neck and groin area. What stage is this?
a. IB
b. IIIb (assuming the question had B symptoms)
c. IV A

A

b. IIIb (assuming the question had B symptoms)

68
Q
  1. A diabetic man had microalbuminuria in urine test. How will you manage?
    A. ACE inhibitor
    B. beta blockers
A

A. ACE inhibitor

69
Q

A picture of malar rash presenting with symptoms of renal failure and high urea and
creatinine. What will be positive?

A

Anti-dsDNA antibodies

70
Q

A 75-year-old has chest pain with exertion the past 2 months then had 2 episodes of fainting
a. MS
b. MR
c. AS
d. AR
e. Respiratory something

A

c. AS

-One of the etiologies of AS is calcified aortic valve that occur in elderly.
-Other etiologies include :congenital(bicuspid, unicuspid),and rheumatic disease.
-Clinical presentation of AS include:
1)Angina
2)Syncope
3)CHF
-Pathophysiology of AS and its clinical presentation:Outflow obstruction->increased EDP->concentric LVH->LV failure
->subendocardial ischemia.

71
Q

A patient with B symptoms and bloody diarrhea underwent colonoscopy. It showed inflamed mucosa with ulceration from the rectum to the transverse colon. What else you will look for?
a. fistula
b. Sclerosing cholingitis

A

A clinical picture of bloody diarrhea along with inflamed mucosa with ulceration on pathology indicates ulcerative colitis, which is closely associated with sclerosing cholingitis.

72
Q

What is the most sensitive way to confirm COPD?
a. low FEV 50%-75%
b. measurement of airflow and lung volumes
c. lung volumes such as tidal lung capacity, and total volume
d. lung volume such as ERV, total volume and tidal lung capacity

A

b. measurement of airflow and lung volumes
PFT (spirometry) is the definitive diagnostic test. Obstruction is based on decreased FEV1 and FEV1/FVC ratio, as well as increased TLC, RV, and FRC (these are lung volumes). Vital Capacity (VC) is decreased.

73
Q

A 24-year-old female with bilateral pain in her wrist and morning stiffness lasting more than one hour. What is your diagnosis?
A. Osteoarthritis
B. Osteoporosis
C. Rheumatoid arthritis

A

C. Rheumatoid arthritis (inflammatory pain)

74
Q

A question about MLF lesion

A

-