2. RESEARCH METHODS Flashcards
Research
What is the definition of research?
The systematic study of a subject in order to establish facts and reach new conclusions.
Research
What are some synonyms for research?
- Investigation,
- experimentation,
- testing,
- exploration,
- analysis,
- fact-finding,
- examination.
What is isolated research?
Research that looks only at an isolated part of the whole picture and thereby draws false conclusions from it.
What is science?
the systematic study of the structure and behaviour of the physical and natural world through observation and experiment
How does the medical approach to disease view symptoms?
The symptom is seen as the disease and cause at the same time.
Why might a patient be pronounced ‘healthy’ even if they feel sick?
If no measurable or observed symptoms are found, the patient is pronounced ‘healthy’, even though they feel sick.
When symptoms have become chronic over decades, and measurable tissue changes have taken place, a patient can be declared as “sick”, often too late to be successfully treated.
What is the issue with treating symptoms without addressing the cause?
The disease continues, and the patient may get worse over time and deal with adverse effects resulting from the “orthodox” treatment given.
What is an example of suppression in medical treatment?
Using anti-inflammatories for fever, painkillers for pain, and anti-histamines for allergies.
Suppression drives the disease deeper into the body.
It makes a symptom disappear without treating the true cause
Why is getting rid of amyloid-ß not a successful treatment for Alzheimer
Aß or Amyloid-beta is part of a protective response, and removing it can be damaging
Natural medicine looks at WHY ß-Amyloid has formed.
Amyloid is a potent pathogen fighter and part of a protective response of the brain to invading pathogens and suboptimal levels of nutrients
What is a common shortcoming of medical research?
- Not searching for the true causes of disease
- **Isolates specific aspects **of the problem without reference to the whole picture
- set out to prove what the industry wants to sell
- Naive approach (remove the symptom)
Isoltated situations: in vitro, research on tissues, controlled clinical trials)
Why are animal studies in medical research problematic?
- Laboratory animals are under stress, leading to distorted results, and the studies can be inhumane and brutal.
- Animal physiology is different from human.
What are the two competing paradigms in disease theory?
Germ Theory (disease comes from outside the body - Louis Pasteur) and Terrain Theory (disease occurs from within the body - Antoine Béchamp).
Pleomorphism: inert bacteria transform itself - response to the terrain
Bacteria/viruses are the after-effects not the cause of the disease. Diseases are the result of an acidic, low oxygenated terrain, where the diseased tissue suppourts the growthof micro-organisms which can develop in different forms (pleomorphism)
What is an RCT in medical research?
Randomised Controlled Trial:
- a ‘gold standard’ clinical trial often involving a drug tested against a placebo,
- is conducted on humans, with identical pathology and no other complicating factors
- subject to strict rules (i.e. double-blinding)
What are some weaknesses of RCTs?
- They don’t reflect real life,
- assume patients are identical,
- and can have cherry-picked data
Real people don’t come as standard
Coffee healthy? W hat are the negative effects of coffee ?
Latest research promotes coffee as healthy, but :
- leads to physical dependency,
- aggravates other addictions such as smoking, sugar, sweets,..
- impairs sleep,
- increases cortisol, which causes weight gain and suppresses the immune system
- suppresses reproductive and thyroid functions.
Why is alcohol research on its health benefits flawed?
The research is conducted on an isolated constituent of wine which may reduce heart attacks, but it ignores the overall negative effects of alcohol and other variables in lifestyle.
Who generally funds medical and food research? why is this important?
The pharmaceutical and food industries fund it, influencing results to promote their products.
Research
How does natural medicine research differ from biomedical research?
It is based on observations and focuses on individual patient experiences rather than isolated variables.
Research assumptions
What are the research assumptions in Natural Medicine? in Biomedical?
- In Natural Medicine:
* aims to demonstrate the effectiveness of a treatment strategy
* no patent for natural products and treatments –> no profit
* embraces complexity and variability as part of life anf patient experience
* assumes that patients are different (bioindividualisation of ttt) - In Biomedical:
* aims to demonstrate the effectiveness of a single treatment
* funded by vested interests for major profits
* test simplistic hypotheses (cuts out complexity and variability
* assume people are all the same and will respond similarly to drugs
Qualitative research
What are the benefits of qualitative research in natural medicine?
It encompasses variability and complexity, focuses on experiences, and admits changing perspectives.
It refers to any research that is impossible to accurately measure (how people feel about sth,..)
Case study
What is a case study in natural medicine research?
Detailed notes on patient consultations, used to compare treatment effectiveness in real-world settings, individual responses to ttt.
Clinical audits
What is the purpose of clinical audits?
To determine whether best practices are being carried out and to draw data regarding treatment effectiveness
Outcomes research
What is outcomes research?
Research that assesses the delivery of care, use of resources, and benefits to patients.
Biomedical research
What are some methods used in qualitative research?
Interviews, questionnaires, and observation.
What is an emic perspective?
Understanding the thoughts and beliefs of local people from the inside
What is an etic perspective?
Studying cultures scientifically from the outside
Biomedical research
What is the role of ethics in biomedical research?
Ensuring beneficence (act of doing good), non-malfeasance (do not harm), confidentiality, and informed consent
Research on animals is not ethical.
What is narrative medicine?
A qualitative approach using patients’ narratives to understand their health problems better
Biomedical research
How to read research ?
- find out who wrote it (vested interests)
- who publishes it
- who funds it
- how is the design
- suggestion of bias, confounding factors)
- is the interpretation justified?
- what are the outcome measures
Q°: what are they gaining from the study?
Look for declarations: if there are conflicts of interest these should be made clear.
Look also at the reference list and bibliography for eventual “circular referencing” (using their own previous research as references)
What is the significance of good research principles?
They ensure the integrity, reliability, and validity of research findings.
Lack of bias and confounding factors, declaration of conflicts of interest, ethical conduct of researchers.