2. Path Markers - Path Flashcards
Pathologic Markers for Prostate Cancer
- PSA
- Prostatic acid phosphatase
PSA
Prostate specific antigen
- Used to screen for prostate carcinoma
- Can also be elevated in BPH and Prostatitis
Prostatic Acid Phosphatase
- Marker of prostate carcinoma
CEA
Carcinoenbyonic antigen
- Very non-specific
- Most colorectal and pancreatic cancers
- Some gastric, breast, and thyroid medullay carcinomas
Pathologic Marker for Non-Seminomatous Germ Cell Testicular Tumors (Yolk Sac Tumor)
a-fetoprotein
a-fetoprotein
- Marker for Non-Seminomatous Germ Cell Testicular Tumors (Yolk Sac Tumor)
- Low levels seen in Down’s syndrome
- High levels seen in neural tube defects
Pathologic Marker for Hydatidiform Moles
b-HCG
- Levels also increased in Choriocarcinoma and Gestational trophoblastic tumor
b-HCG
Human Chorionic Gonadotropin
- Marker for Hydatidiform moles, Choriocarcinomas, and Gestational trophoblastic tumors
“HCG = Hydatidiform moles, Choriocarcinoma, Gestational trophoblastic tumor”
Pathologic Marker for Choriocarcinoma
b-HCG
- Levels also increased in Hydatidiform moles and Gestational trophoblastic tumor
Pathologic Marker for Gestational Trophoblastic Tumor
b-HCG
- Levels also increased in Choriocarcinoma and Hydatidiform moles
Pathologic Marker for Ovarian Cancer
CA-125
- Levels also increased in malignant epithelial tumor
Pathologic Marker for Malignant Epithelial Tumors
CA-125
- Levels also increased in Ovarian cancer
CA-125
Marker for Ovarian cancer or Malignant epithelial tumor
Pathologic Marker for Melanoma
S-100
- Levels also increased in Neural tumors and Schwannomas
Pathologic Marker for Neural Tumors
S-100
- Levels also increased in Melanoma and Schwannomas
Pathologic Marker for Schwannoma
S-100
- Levels also increased in Neural tumors and Melanoma
S-100
Marker for:
- Melanoma
- Neural tumors
- Schwannomas
Pathologic Marker for Bone Metastases
Alkaline Phosphatase
- Levels also elevated in Obstructive biliary disease and Paget’s of the bone
Pathologic Marker for Obstructive Biliary Disease
Alkaline Phosphatase
- Levels also elevated in Bone metastases and Paget’s of the bone
Pathologic Marker for Paget’s of the Bone
Alkaline Phosphatase
- Levels also elevated in Obstructive biliary disease and Bone Metastases
Alkaline Phosphatase
Marker for:
- Metastases to the bone
- Obstructive biliary disease
- Paget’s of the bone
Pathologic Marker for Neuroblastoma
Bombesin
- Levels also elevated in lung and gastric cancer
Pathologic Marker for Lung Cancer
Bombesin
- Levels also elevated in Neuroblastoma and Gastric cancer
Pathologic Marker for Gastric Cancer
Bombesin
- Levels also elevated in Neuroblastoma and Lung cancer
Bombesin
Marker for:
- Neuroblastoma
- Gastric Cancer
- Lung Cancer
Pathologic Marker for Hairy Cell Leukemia
TRAP
- Tartrate-resistant acid phosphatase
“TRAP the HAIRY animal”
TRAP
- Tartrate-resistant acid phosphatase
- A marker for Hairy cell leukemia - a B cell neoplasm
Pathologic Marker for Pancreatic Adenocarcinoma
CA-19-9
CA-19-9
Marker for Pancreatic adenocarcinoma
Pathologic Marker for Thyroid Medullary Carcinoma
Calcitonin
High Calcitonin Levels
Marker for Thyroid Medullary Carcinoma
Psammoma Bodies
Marker for:
- Papillary thyroid adenocarcinoma
- Serous papillary cystadenocarcinoma of the ovary
- Meningioma
- Malignant mesothelioma
“PSaMMoma = Papilly thyroid adenocarcinoma, ovarian Serous papillary cystadenocarcinoma, Meningioma, Mesothelioma”
Pathologic Marker for Papillary Thyroid Adenocarcinoma
Psammoma Body
- Also seen in Ovarian serous cystadenocarcinoma, Meningioma, Mesothelioma
“PSaMMoma = Papilly thyroid adenocarcinoma, ovarian Serous papillary cystadenocarcinoma, Meningioma, Mesothelioma”
Pathologic Marker for Ovarian Serous Cystadenocarcinoma
Psammoma Body
- Also seen in Papillary thyroid adenocarcinoma, Meningioma, Mesothelioma
“PSaMMoma = Papilly thyroid adenocarcinoma, ovarian Serous papillary cystadenocarcinoma, Meningioma, Mesothelioma”
Pathologic Marker for Meningiomas
Psammoma Body
- Also seen in Papillary thyroid adenocarcinoma, Ovarian serous cystadenocarcinoma, Mesothelioma
“PSaMMoma = Papilly thyroid adenocarcinoma, ovarian Serous papillary cystadenocarcinoma, Meningioma, Mesothelioma”
Pathologic Marker for Mesothelioma
Psammoma Body
- Also seen in Papillary thyroid adenocarcinoma, Ovarian serous cystadenocarcinoma, Meningioma
“PSaMMoma = Papilly thyroid adenocarcinoma, ovarian Serous papillary cystadenocarcinoma, Meningioma, Mesothelioma”
