2 Normal Aging pt.2 Flashcards

1
Q

Art 3

Definition of Gerontopsychology

A
  • It explores the effects of ageing on the brain and on personality. It explores how cognitive functions change with ageing and how individuals can cope with such change in order to maintain a high quality of life. An important age-related cognitive change is dementia, which is a disease that causes people to lose their memory and their capabilities.
  • Gerontopsychology assumes that processes of development and change in the course of ageing are not necessarily unidirectional decline processes. Rather they are multidirectional or stable.The focus of gerontopsychology is on the developmental potentials of ageing individuals’ (personal and environmental) resources, thereby stimulating the shift from pathological- to healthy ageing
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2
Q

Art 3

The two basic concepts of gerontopsychology

A

Cognitive health=
Cognitive health is not just the absence of disease, but rather the development and presentation of cognitive abilities that allows the elderly to maintain social connections, a sense of purpose, to function independently, to recover from illnesses and to cope with functional deficits.
2. Quality of Life=
The QoL is the subjective representation of the functionality of one’s resources (‘Can I perform complex activities that serve my life-goals?’).

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3
Q

Art 3

There are two types of cognitive abilities

A

Fluid intelligence=
Processing of information, working memory, cued and free recall, reasoning and verbal fluency. Decreases with age.
- Crystallized intelligence=
Experience- and culture-dependent non-speeded performance such as vocabulary. Increases with age

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4
Q

Art 3

main theories that explain age related differences in fluid and crystallized intelligence

A

The processing speed theory=
Age related differences in performance are a consequence of a general decrease in speed of performing mental operations. This is related to all the aspects of cognition (with or without the speed component).
2. The resources theory=
Age related decline is cognitive functioning is the result of reduced processing of attentional resources (in the working memory), which are used to manipulate and process information.
3. The inhibitory deficit theory=
Age related decline in cognitive functioning is the result of the decline in inhibitory control. This inhibitory control is the ability to suppress irrelevant information, which could lead to less workspace for new materials in the working memory.
4. The Sensory Deficit Theory=
Deficits in sensory functioning are linked to deficits in cognitive functioning (common cause hypothesis: sensory function, as a general marker of the intactness of the neurobiological architecture
is fundamental for all cognitive functions and has, when it declines, a generally negative effect on all cognitive abilities).

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5
Q

Art 3

Schaie

A

Most age-differences in cognitive performance are the result of cohort differences, rather than age differences. Conclusion: the universal decline in adult intelligence is at best an methodological artifact.
This suggests that other factors than age and practice in specific cognitive skills should be considered when looking at the development of cognitive abilities during a life span.

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6
Q

Art 3

Cognitive health

A

Cognitive health=
The individuals’ ability to adapt their cognitive performances to changes in the environment and focus on the ability to stabilize cognitive functioning.
Plasticity=
Is the individual’s latent cognitive potential or its cognitive capacity under certain specified conditions. It is closely connected to cognitive health. Cognitive plasticity should be observable in both neuronal and behavioral data. The exact relationship between them is still unclear. Some researchers have demonstrated that in older people there are only small or negative effects between cognitive performance and the reductions in cortical volume.
- The theory of active cognitive reserve=
Brain activity copes with or can compensate for pathology. This is observed in individuals with higher levels of intelligence and higher educational achievements

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7
Q

Art 3

Quality of Life

A

There are two main approaches to determine QoL in old age:
1. sQoL=
A subjective evaluation of an individual’s overall life situation. This is a subjective state, which reflects the discrepancy between the individual’s current life situation and the ideal/optimal life situation.
2. oQoL=
The QoL from the outside from an individual, for example: measuring health impairments. This is an objective measure. The higher the oQoL, the better (less impaired) the resources of the individual are. (Note: it doesn’t take into account individual differences).
fQOL model=
QoL as an integration of multiple subjective representations of the functionality of one’s resources. A higher fQoL means that someone’s resources are more strongly, so the person is able to perform complex activities that serve their goals in life. It is a subjective assessment, but not about the satisfaction, it is an assessment about one’s functionality.

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8
Q

Art 3

Individual Coping Strategies

A

Individual Coping Strategies=
QoL and cognitive health depend strongly on personal and environmental factors and also on one’s abilities to adapt to different environments and situations. A self-regulatory mechanism that helps a successful and healthy adaptation, is the selective optimization with compensation strategy (SOC).
- Selection=
Choosing tasks of high individual performance & that match the individual’s abilities.
o Elective selection (ES)=
Guided by preference or social norms.
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Downloaded by Michelle Maslin
(mlennonmaslin@gmail.com)
o Loss-based selection (LS)=
Guided by a loss of internal or external resources.
Because of loss of resources, the number of achievable goals decreases with age.
- Optimization=
To achieve a selected goal, persons have to optimize their strategies by acquiring, refining and deploying resources. It can be realized through learning, training and high motivation.
- Compensation=
The acquisition of alternative ways to reach given personal goals in face of decreases in resources.
A correct utilization of the SOC strategy should lead to better health, successful ageing and improved relationship quality.

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9
Q

Art 3

Another self-regulatory approach is related to cognitive functioning

A

‘Resource orchestration strategy’=
This strategy assumes that performance of complex cognitive tasks requires dynamic orchestration and timing of multiple skills. So, improvements in simple mental abilities is unlikely to improve complex, integrated behavior. Interventions based on this model focus on improving the orchestration processes itself by identifying goals, relevant abilities and making optimal decisions.

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10
Q

Art 3

The current state of Europe

A

One of the biggest challenges is the prevalence of dementia (a faster loss of cognitive abilities than normal ageing). The results of dementia:
- Losing memory
- Later: losing physical functioning.
Average of Europe’s population with dementia is 6,2%. 60-70% of that population suffers from a specific dementia: Alzheimer’s Disease (AD). This number is higher than that of Asia and Africa (probably due to the fact that these are less developed continents and therefore have shorter life expectancies). In 2050, the number of dementia disease will double, and in less developed regions even triple!

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11
Q

Art 3

Can we stop dementia?

A

Therefore, we should identify the resources, the way they interact and the factors that contribute to strengthen cognitive resources.
1. Individual and environmental resources:
o Cognitive and intellectual stimulation.
Could prevent dementia, contributes to cognitively healthy ageing.
Global cognitive stimulation is more effective than training of specific cognitive functions.
o Physical conditions: absence of diabetes and nutritional factors Has a protective effect on dementia.
o Socially and physically stimulating activities.
2. Adaptation of the environment:
Adults with dementia also have housing and care needs, this must be an individual adaptation to the environment.
There are differences in Europe in care provision= South Europe: family predominantly provides care. Western Europe: collective responsibility, majority of dementia patients still cared for at home.

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12
Q

Art 4
Social Gerontology
and the three levels

A

Studies the social context of ageing.
It focusses on 3 broad areas of activity=
1. Macro-level perspective=
Examining the demographic, structural, cultural and economic transformations due to the increase of older people. The social effects of population ageing.
SOCIETY
2. Meso-level perspective=
Studying the social context and social structures of groups and individuals. For example: gender, class, ethnicity, etc.
SPECIFIC GROUPS
3. Micro-level perspective=
Studies the individual level of experience of old age. For example: social roles, meaning and interpretation of old age. INDIVIDUALS

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13
Q

Art 4

The theory and theoretical perspectives in social gerontology have been perceived as problematic

A

There seems to be an imbalance between the accumulation of data and the development of theory.

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14
Q

Art 4

Three theories for ageing at the individual micro-level

A
  1. Disengagement Theory
  2. Activity Theory
  3. Continuity Theory
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15
Q

Art 4

Disengagement Theory

A

Natural and inevitable disengagement from the workplace and social relationships. A smooth transfer of roles, prepares the elderly for ultimate withdrawal: death. Older adults will go to a ‘triple loss’:

  1. Loss of social roles;
  2. Loss of social contacts;
  3. Loss of engagement in social values

Isolation is the manifestation of the disengagement theory. Critics:

  • Validating the neglect of real problems of older people.
  • Supporting indifference towards lonely and isolated older people. - Devaluating contributions of older people to society.

As a response to these criticisms: Activity Theory

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16
Q

Art 4

Activity Theory

A

Maintenance of roles and relationships is the key to a successful old age. When people age, new activities and roles should be adopted to compensate for losses. This is the first theory that promotes ‘successful’ ageing.
Both the disengagement and activity theory=
- Are derived from a functionalist school of sociology.
- Suggest that successful ageing is achieved by movement in a single direction. - Are both prescriptive.

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17
Q

Art 4

Continuity Theory

A

Individuals will uphold a lifestyle that resembles their lifestyle at an earlier age. They will seek to preserve activities and roles and any change will be adaptive and incremental. This theory is much less prescriptive and more an adaptive theory loss, maintenance and new roles and activities.

A key critic of the functionalist theories was their failure to engage with the influences of key social structures, such as age, class, gender, etc. These theories didn’t focus on the experiences of individuals.As a response, critical gerontology emerged.

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18
Q

Art 4

Critical gerontology

A

Critical gerontology assumes that old age is socially constructed, generated by interactions with their social context and which are constrained by socio-cultural factors (gender, class, etc.).
- The most influential theory within Critical Gerontology is the ‘Political Economy’ theory of old age (which sought to understand the position of older people and the experience of old age as it related to advanced capitalist society).
- Critics of Critical Gerontology:
o Overemphasis on social class. o Lack of agency and autonomy ascribed to older people.

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19
Q

Art 4

The life course perspective

A

Consists of a series of stages (or social roles) that individuals pass through as they age. This is different for each individual. Usually, but not always, a certain event marks the transition to a new course. Events can shape the years to come, and the social context can influence how the lives of individuals progress. The life course consists of different entities: education, occupation, family, etc. The analysis of the life course can be done on three different types of time:
- Historical time.
- Biological time. - Social time.
This perspective isn’t used very often to understand social relationships.

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20
Q

Art 4

The current state of Europe in social gerontology

A

Pre-old age characteristics cause a lot of variance among older adults in Europe. Successful ageing is determined by longevity and QoL. These are prompted by the interaction between three sets of factors:

  • Social engagement / participation.
  • Reduction of disease.
  • Promotion of physical and mental functioning.
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21
Q

Art 4

The variations between older Europeans in social functioning can be categorized in three levels

A
  1. Contact with relatives or friends.
  2. Perceived evaluation of social contact.
  3. Loneliness.
22
Q

Art 4

Social participation

A

Is high in the Northern countries, and low in the Southern and Eastern countries

23
Q

Art 4

Social networks

A

Convoy model of support (‘convoys’ of support vary between individuals and over time). Social networks are high in the Northern countries and low in the Southern and Eastern countries.Satisfaction of relations shows an unclear pattern.

24
Q

Art 4

Loneliness

A

Is the gap between;

  • Desired quantity and quality of social relationships.
  • The reality of an individual’s social engagement.

Loneliness is high in the Soviet Block countries (Eastern Europe) and low in the Northern countries.

Age, gender and physical health have NO consistent relation with loneliness, the expectation about one’s health does have a relationship with loneliness. Also, the post-war population of migrants seem to report higher rates of loneliness. Young and midlife adults with poor health also report higher degrees of loneliness.

25
Q

Art 4

Globalisation

A

The trend whereby the world is becoming increasingly interconnected. This could influence older people adversely: widening the inequalities between older people and working age people

26
Q

Lec

Parkinson´s disease

A

Crash Rates and Errors
- No increased risk of crashes compared to age-matched controls
- Majority (2/3) of drivers with PD pass BTW
- Drivers with PD are more likely to commit errors:
o Lane changing, failing to check blind spot, reduced usage of mirrors, backing out of
space, indecisiveness at intersections
Cognition
Research designs:
- Prediction of error counts in BTW exam
- Comparing PD drivers evaluated as safe, unsafe or marginal sage
- Comparing PD drivers passing and failing simulation ride
Neuropschological measures relevant for driving in PD
- Executive functions (i.e. Trailmaking Test B)
- Visuospatial abilities
- Visual attention

27
Q

Lec

How do we study the aging brain?

A
  • Post mortem
  • Problem: limited sample sizes
  • Recent years: neuroimaging techniques
For the structure of the brain:
- Computerized Tomography (CT)
- Magnetic Resonance Imaging (MRI)
For the activity of the brain:
- Functional Magnetic resonance imaging (fMRI)
- Positron Emission Tomography (PET)
28
Q

Lec

Changes in the Human Brain

A

Weight of the brain can decrease up to 10% by the 10th decade.
Male brain is heavier.
Weight of the brain relative to body weight stays relatively stable from the age of 20 years and older.

29
Q

Lec

Brain volume

A

Cerebral cortex as a whole declines:

  • 0,12% per year in younger adults
  • 0,35% per year in 52+

Strong differences between regions
-Some show relatively steep decline, other stable volume over time

30
Q

Lec

Grey matter

A

Reduction in: caudate nucleus, lateral prefrontal cortex, cerebellar hemispheres, hippocampus
Stable, or minimal reduction in: primary visual cortex, entorhinal cortex
Age related atrophy of grey matter differs across regions:
- Frontal lobes show steepest rate of atrophy (0,9-1,5% per year)
- Pariental lobes second steepest rate of atrophy (0,34-0,9% per year)
Decline becomes steeper with increasing age:
- Hippocampus (0,86% py in 26-82 years and 1,85% py in 70+)

31
Q

Lec

White matter

A

Changes throughout the entire brain. Greatest lost in frontal regions (white matter loss is more
extensive than grey matter loss).
Anterior to posterior gradient!

32
Q

Lec

Brain cavity and cerebrospinal fluid

A

Between 20 and 50 the brain occupies 90% of the cranial cavity.
Thereafter: the brain occupies progressively less space:
- Increase in the volume of cerebrospinal fluid and widening of the sulci

33
Q

Lec

Neurotransmitters – the case of Dopamine

A

Two main families of dopamine receptors (D1 and D2)
Aging: loss of D1 and D2 receptor binding (decrease 7-10% per decade!!)
Dopamine transporter: 4,4-8% per decade
Anterior to posterior gradient!

34
Q

Lec

Strucual changes SUMMARY

A
  • Both white and grey matter decline in aging
    o Most prominent in advanced aging
    o Anterior-posterior gradient
    o Brain occupies progressively less space in brain cavity
  • Neurotransmitters: loss of receptors and transporters

Do these structural changes have a negative influence on cognition? Yes!!
- Significant correlations between the decline of the structure of the brain and cognitive
functioning
- Do all cognitive functions show an age-related decline?
o Decline in: Speed of processing, working memory, Long-term memory,
o Mild decline: Short-term memory
o Increase: Verbal knowledge
No differences between cultures on non-verbal neuropsychological tests!
Differences between cultures in verbal neuropsychological tests!

35
Q

Lec

Functional changes in the brain

A
  • Neural activity associated with cognition shows both age-related decreases as well as
    increase!
    o Young adults and older adults (partly) recruit different areas of the brain for the same
    task
  • Refers to age-related compensation and adaptation
  • Two patterns
    o Posterior-Anterior Shift in Aging (PASA)
    o Hemispheric Asymmetry Reduction in older adults (HAROLD)
36
Q

Lec

Posterior-Anterior Shift in Aging (PASA)

A

Older adults show:
- Decreased activation in posterior areas of the brain
- Increased activation in anterior areas of the brain
o Involvement of higher order cognitive processes
- Additional recruitment of higher order functions allow older adults to maintain a good
accuracy level, most often at the expense of slower reaction time!!

37
Q

Lec

Hemispheric Asymmetry Reduction in older adults (HAROLD)

A

Examples with word-pair cued recall, word-stem cued recall and word recognition.
Two explanations:
1. Compensation
a. Bilateral activity is associated with successful cognitive performance
b. Found in high-performing rather than low-performing older adults
2. Dedifferentiation account: more widespread activation reflects an age-related difficulty in
engaging specialized neural mechanisms

38
Q

Lec

Cognitive Functions

A

Memory: Implicit memory, episodic/declarative memory (encoding, retrieval, recognition)
Executive functions: planning, cognitive flexibility, set-shifting, inhibition, working memory
Attention: Sustained, Divided and selective attention
Visual perception: space perception, object perception, face perception
Language, etc….
Visual perception attention and recognition memory
- Age related occipital decrease accompanied by frontal increase = PASA
Working memory, language, memory encoding and retrieval
- Age related decrease in hemispheric asymmetry = HAROLD
 PASA and HAROLD are differentially related to different cognitive functions!

39
Q

Lec

Brain Daza and cognitive Aging theories

A
  1. Sensory deficit theory
  2. Resources deficit theory
  3. Speed deficit theory
  4. Inhibition deficit theory
  5. Scaffolding Theory of Aging and Cognition
40
Q

Lec

1. Sensory deficit theory

A

Age related deficits in sensory processes play a major role in age-related cognitive decline
Older adults show considerable deficits in simple vision and auditory processing
Strong correlations between age-related differences in sensory processing and cognitive
performance!
Top down compensation for bottom-up, because bottom up doesn’t work so good anymore!

41
Q

Lec

2. Resources deficit theory

A

Aging is associated with a reduction in the amount of attentional resources
- Result: deficit in demanding cognitive tasks
- Deficits are smaller when environment provides support
Support: when attentional resources are reduced in younger adults, they tend to show cognitive
deficits that resemble those of older adults.
Also support from neuroimaging studies:
- Attention relies strongly on the prefrontal cortex (PFC)
- Older adults tend to show decreased activation in part of PFC that are activated during
attention tasks in younger adults
- Older adults tend to show more bilateral pattern of PFC activity during attention tasks
- HAROLD

42
Q

Lec

3. Speed deficit theory

A

Older adults cognitive deficits reflect a general reduction in the speed of cognitive processes
Two mechanisms:
- The time required by early operations reduces the time available for later operations (limited
time mechanism)
- The products of early operations are lost or irrelevant by the time later operations are
completed (simultaneity mechanism)
Is one of the most popular cognitive aging theories!
Processing speed declines steadily with age.

What Mechansisms?
1. White matter deterioration
a. Deterioration of the myelin sheath aroung axons which support speed of neural
transmission along acons
2. Increase of neural network that supports cognitive performance
a. PASA and Harold = More ares an other ares of the brain recruited to perform a
cognitive task = Costs more time!

43
Q

Lec

4. Inhibition deficit theory

A

Age related cognitive decline is due to a decline in the inhibitory control of working memory contents
- When inhibitory control fails, goal-irrelevant information gains access to working memory
- Result: “mental clutter” which impairs working memory
Support: Older adults
- Better remember disconfirmed solutions
- Better remember to be forgotten information
Differences between:
- Regions that exert inhibition (inhibitory control regions)
o Often anterior regions
- Regions affected by inhibition
o Often posterior regions
- Older adults show weaker activity than younger adults in inhibitory control regions
- Older adults show greater activity in regions that are supposed to be inhibited (ie
disinhibition) than younger adults

44
Q
  1. Scaffolding Theory of Aging and Cognition
A

STAC model: accounts for the possibility of both deficient and preserved performance on cognitive
tasks
- Acknowledges that the aging brain must adapt to neural challenges including atrophy
- To cope: the brain builds alternative neural circuitry, or scaffolds
- Scaffolds: represent compensatory strategies and allow older adults to maintain a high level
of activation
Mode is not specific to old age, but to the life span as the brain is confronted with cognitive
challenges!!

45
Q

Interim SUMMARY

A

Age-related cognitive decline may be best understood in terms of a range of mechanisms, including:
Speed deficit, vision and hearing deficit, working memory deficit and inhibition deficit
Model that combines all: Scaffolding Theory of Aging and Cognition (STAC)
Behavioral performance of older adults: combined influence of age-related neurocognitive decline +
age-related compensatory processes

46
Q

Lec

Summary pt.1

A
  1. The basic hardware of cognition significantly declines with advanced age, although
    knowledge and expertise are relatively protected from age-related decline. Neural structures
    also show changes. Many brain structures show significant shrinkage, the integrity of the
    white matter decreases, and dopamine depletion occurs.
  2. In contrast to age-related declines in cognitive function and brain structure, functional brain
    activity increases with age, particularly in the frontal cortex. The proposed scaffolding theory
    of aging and cognition suggests that this increased functional activity is due to compensatory
    scaffolding, i.e. the recruitment of additional circuitry with age that shore up declining
    structures whose function has become noisy, inefficient, or both.
  3. Prefrontal cortex is the most flexible structure of the brain, and brain scaffolding processes in
    the aging brain largely reside in this structure
  4. Scaffolding is the brain’s response to cognitive challenge and is not unique to aging. Aging
    simply results in more frequent cognitive challenges at lower levels of intensity.
47
Q

Lec

Summary pt.2

A
  1. Scaffolded networks that develop with age may be less efficient than the original, direct and
    finely honed networks developed at younger ages.
  2. The aged brain is less efficient at generating scaffolding, and significant pathology (as occurs
    in e.g. AD) may entirely limit scaffolding operations.
  3. The causes of cognitive aging are multifactorial, and individuals will vary in both the
    magnitude of decline and the amount of protective scaffolding that can be activated.
  4. Scaffolding is promoted by cognitive activity. Evidence suggests that changes in cortical
    structures can occur as a result of external challenge, and growing evidence suggests that
    humans develop scaffolds as a result of stimulating experiences.
48
Q

Lec

Individual differences

A

Why do individuals vary in both the magnitude of cognitive decline and the amount of protective
scaffolding that can be activated?
- Variation in the level of cognitive decline
- Decline in brain structure ungleich sverity of cognitive decline!

49
Q

Lec

Cognitive reserve

A

Cognitive reserve: individual differences in cognitive processes or neural networks underlying task
performance allow some people to cope better with decline in brain structures than others.
Measurment of cognitive reserve:
- Intelligence (chrytellized intelligence), level of education, work level, literacy, integrity of social
relations, activities in spare time
- People with a low cognitive reserve show relatively early a decline in cognitive performance relative
to the decline in brain structures
- People with a high cognitive reserve show a relatively late a decline in cognitive performance relative
to the decline in brain structure

50
Q

Lec

When is behavior abnormal?

A

Is someone ill or just wooried?
Three factors that have a major influence on cognitive performance:
1. Age
2. Level of education
3. Gender
Always compare a performance with the performances of people of the same age, the same egnder
and the same level of education
Definition: a performance is abnormal when a person obtains a score that is 2SD=+ below the
average of the normative data sample (lowest or highest 2,27% of population)

51
Q

Lec

Differential Diagnosis

A

Definition: the determination of which of one of several diseases may be producing the symptoms
Common practice in neurology and also in the diagnosis of different types of dementia
Is used to prevent several errors, including:
1. Putting the emphasis on one or few results
2. If you often work with patients with AD you will have the tendency to diagnose this disease
more often
3. Putting the emphasis on results that confirm a diagnosis

52
Q

Lec Summary

A
  • Healthy aging is accompanied by structural decline of the brain (white and grey matter,
    neurotransmitter receptors and transporters)
  • Most cognitive functions show a steadily agerelated decline
  • Healthy aging is accompanied by changes in functional activity
    o PASA and HAROLD
  • The proposed scaffolding theory of aging and cognition suggests that this increased
    functional activity is due to compensatory scaffolding, i.e. the recruitment of additional circuitry with age that shores up declining structures whose function has become noisy,
    insufficient or both.
  • A performance is abnormal when a person obtains a score that is 2SD=+ below the average of
    the normative sample data
  • Always compare a performance with the performances of people of the same age, the same
    gender and the same level of education
  • Differential Diagnosis: the determination of which of one of several disease may be producing
    the symptoms
    o Important to prevent diagnostic errors
    o E-g- needed to determine whether complaints are due to healthy aging or a disease
    process.
    Differential diagnoses is the tree where you check the symptom from different diseases with the
    current symptoms, if all fit, you take that diagnose (confirmed or not confirmed