2- equations Flashcards
1
Q
half life equation
A
t1/2= (0.693 x Vd ) / CL
2
Q
loading dose equation
A
loading dose =( Css x Vd ) bioavalibility (usually 1)
Css= desired concentration in plasma
3
Q
maintenence dose
A
(clearance x [plasma] wanted /bioavalibility) x dose interval
4
Q
theraputic index
A
toxic dose/ theraputic index
5
Q
volume of distribution =
A
Vd = dose / plasma concentration drug in L/Kg(!!!)
6
Q
what does a small Vd suggest
A
a small Vd suggests that drug is confined to plasma and ECF and so less reaches active site.
7
Q
how many micrograms in a miligram
A
1000
8
Q
how many miligrams in a gram
A
1000
9
Q
potency equation
A
concetration giving 50% max response
10
Q
oral bioavalibility
A
systemic circulation /IV
11
Q
renal clearance
A
urine concentration x urine flow / plasma concentration
