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2MB MSK Cortext > 2- Connective Tissue Diseases > Flashcards

2- Connective Tissue Diseases Flashcards

1
Q

What is the basic pathology behind CTDs?

A

Autoimmunity producing antibodies against cells of the body

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2
Q

SLE is more common in whom?

A

Black people

Women 11:1 men

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3
Q

Which antibodies are associated with SLE?

A 
ANA
Anti-dsDNA
Anti-Sm
Anti-Ro
Anti-La
Anti-RNP
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4
Q

Complement levels are high in active SLE. True/False?

A

False

Low

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5
Q

Why is urinalysis done in SLE?

A

Look for glomerulonephritis

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6
Q

Outline management for mild (skin) SLE

A

Hydroxychloroquine
Topical steroid
NSAID

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7
Q

Outline management for moderate SLE

A

Immunosuppression

Steroid

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8
Q

Outline management for severe SLE

A

IV steroid

Cyclophosphamide

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9
Q

What is the basic pathogenesis in Sjogren’s syndrome?

A

Autoimmune destruction of exocrine glands

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10
Q

List clinical features of Sjogren’s syndrome

A

Dry mouth/eyes

Parotid swelling

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11
Q

Which autoantibodies are associated with Sjogren’s syndrome?

A

Anti-Ro

Anti-La

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12
Q

What is the basic pathogenesis in systemic sclerosis?

A

Excess collagen deposition, causing skin and organ changes

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13
Q

What is the difference between limited and diffuse systemic sclerosis?

A

Limited - mainly confined skin changes

Diffuse - rapid skin changes and early organ involvement

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14
Q

Which systemic sclerosis - limited or diffuse - is associated with anti-centromere Ab?

A

Limited

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15
Q

Which systemic sclerosis - limited or diffuse - is associated with anti-Scl-70 Ab?

A

Diffuse

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16
Q

What is a common skin change that occurs in systemic sclerosis?

A

Raynaud’s phenomenon

17
Q

CREST describes findings in systemic sclerosis - what does it stand for?

A 
Calcinosis
Raynaud's phenomenon
Oeseophageal dysmotility
Sclerodactyly
Telangiectasia
18
Q

List features of mixed CTD

A 
Raynaud's phenomenon
Arthralgia/arthritis
Myositis
Sclerodactyly
Pulmonary hypertension
ILD
19
Q

What does antiphospholipid syndrome increase the risk of?

A

Increased clotting, leading to thrombosis

20
Q

In females, what is the important common consequence of antiphospholipid syndrome (APS)?

A

Pregnancy loss

21
Q

Which immunological factors are associated with APS?

A

Lupus anticoagulant
Anti-cardiolipin antibody
Anti-beta-2-glycoprotein

22
Q

Outline treatment for APS

A

Anticoagulation for those with thrombosis

LMWH in pregnancy

2MB MSK Cortext (22 decks)

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