2 - Anesthesia Flashcards
Normal pH of local anesthetics:
5.5 - 6.0
Do not work well in infected tissue (more acidic environment)
Can add bicarb to buffer
How do most local anesthetics work?
Block Na channels and impair propagation of action potentials
Thinner nerve fibers and myelinated fibers are more easily blocked
Advantages of epi in locals
Vasoconstrictor
Increased duration of action
Decreased bleeding
Decreased volume needed for anesthesia
Disadvantages of epi in locals
Increased myocardial activity
Tachycardia
HTN
Dysrhythmias
Avoid in pts with known cardiac dz, HTN, DM, thyroid problems
Describe the ideal anesthetic
Short latency Superior penetration Non-addictive Completely reversible Low toxicity Stable and water soluble Non-irritating Inexpensive
MC adverse effects of local anesthetic
Urticaria
Erythema
Edema
Dermatitis
Txt - O2, Epinephrine, fluids, antihistamine, steroids
Toxicity from locals - prodromal sxs
Cicrumoral numbness / mouth tingling
Tinnitus
Lightheaded / dizzy
Metallic taste in mouth
Toxicity from locals - CV problems
HTN then HOTN
Tachy or brady
CV collapse
Toxicity from locals - severe CNS:
Tonic-clonic activity
ALOC -> unconsciousness
What do you do prior to injecting to avoid intravascular injection?
Aspirate first
Bupivicaine not recommended for:
Kids under 12yrs
Lidocaine dosing
Maximum dose 4mg/Kg WITHOUT epinephrine up to 300mg
Maximum dose 7mg/Kg WITH epinephrine up to 300mg
1% lidocaine has 10mg/ml •
2% lidocaine has 20mg/ml •
Onset 2-5 minutes •
Duration 0.5-2 hours
Management of toxicity
CNS sxs? Hyperventilate
CV sxs? IV fluids for HOTN, txt the arrhythmia
Malignant hyperthermia - MC to succ - txt with rapid cooling, bicarb, dantroline
Method for injecting local
Large coverage with one puncture (longer, small gauge needle
Bent 45 degrees, hub the needle, inject as you withdraw
Sequence of clinical anesthesia
Vasodilation - loss of sympathetic tone
Loss of pain/temp sensation
Loss of pressure sensation
Loss of motor function