2-4

Question 1

how much 02 is transported bound to hgb

Answer 1

98.5%

Question 2

how much 02 is dissolved in plasma

Answer 2

1.5%

Question 3

two forms of 02 transported in blood?

Answer 3

bound to hgb 98.5%
dissolved in plasma 1.5%

Question 4

how many O2 molecules can bind to one hgb molecule?

Answer 4

4 total
1 on each of the 4 pyrroles

Question 5

what is the max 02 carrying capacity of hgb in the blood(in ml/100ml of blood)?

Answer 5

20.1 ml 02

Question 6

percent saturation of hgb with 02 means?

Answer 6

the amount of 02 bound to hgb

Question 7

increased hydrogen
increased PC02
increased temp
increased 2,3 bpg
cause the increased/decreased O2 dissociation and shift the curve left/right?

Answer 7

increased dissociation(02 released, decreased affinity)/shift curve to the right

Question 8

decreased hydrogen
decreased PC02
decreased temp
decreased 2,3 bpg
cause the increased/decreased O2 dissociation and shift the curve left/right?

Answer 8

decreased dissociation(02 loaded, increased affinity)/shift the curve left

Question 9

What are the independent and dependent variables in the 02 hgb dissociation curve

Answer 9

independent-P02
dependent-S02

Question 10

What is the shape of the 02 hgb dissociation curve?

Answer 10

sigmoidal

Question 11

at what point does the 02 hgb dissociation curve transition form steep to nearly flat?

Answer 11

70

Question 12

at what point is the 02 hgb dissociation curve nearly flat

Answer 12

70-100

Question 13

at what point is the 02 hgb dissociation curve steepest

Answer 13

20-40

Question 14

what are the two components of blood oxygen content(Ca02) ?

Answer 14

Pa02-dissolved 02
Sa02-amount of hgb sites saturated with 02

Question 15

what are the independent and dependent variables in 02 hemoglobin dissociation curve?

Answer 15

P02-dissovled oxygen
S02- 02 saturated on hgb

Question 16

2,3 DPG does what when it binds to hgb

Answer 16

allosterically binds, decreasing affinity for 02, rightward shift

Question 17

what does storage of banked blood do to the content of 2,3 BPG?
what can we do about it?

Answer 17

banked blood has a low concentration of 2,3 BPG
we can hypoventilation the patient because hypoxemia causes increased 2,3 BPG

Question 18

what reaction converts C02 to bicarbonate ion?
What enzyme is necessary?

Answer 18

C02+H20—H2CO3 —H +HCO3
carbonic anhydrase catalyzes the formation of carbonic acid

Question 19

what 3 forms is C02 transported in the blood?

Answer 19

dissolved in plasma 5-10%
bound to proteins-globin part of hgb 5-10%
bicarbonate ion 80-90%

Question 20

Bohr effect: influence of CO2 and H+ on Hgb’s affinity for ____ (allosteric regulation)
__ PCO2 and ___ pH (tissues): ↓ affinity of O2 for Hgb (____ shift)
__ PCO2 and___ pH (lungs): ↑ affinity of O2 for Hgb (____ shift)

Answer 20

Bohr effect: influence of CO2 and H+ on Hgb’s affinity for O2 (allosteric regulation)
↑ PCO2 and ↓ pH (tissues): ↓ affinity of O2 for Hgb (right shift)
↓ PCO2 and ↑ pH (lungs): ↑ affinity of O2 for Hgb (left shift)

Question 21

Where in the circulatory system is the bohr effect important

Answer 21

tissues

Question 22

• Haldane effect: influence of O₂ on Hgb’s affinity for CO₂ and H⁺ (opposite of Bohr)
  
  • __ P_O2 (lungs): unload more CO₂ & H⁺
  • ___P_O2 (tissues): load more CO₂ & H⁺

Answer 22

• Haldane effect: influence of O₂ on Hgb’s affinity for CO₂ and H⁺ (opposite of Bohr)
  
  • increased P_O2 (lungs): unload more CO₂ & H⁺
  • decreased P_O2 (tissues): load more CO₂ & H⁺

Question 23

Where in the circulatory system is the haldene effect important

Answer 23

venous blood

Question 24

The C02 curve is what shape?

Answer 24

straight line

Question 25

C02 is ____more times more soluble than 02

Answer 25

24