2-3 McNaughton Flashcards
Alemtuzumab
Fully humanised monoclonal antibody to control inflammation
Targets CD52 - B and T cell destruction
Binds B cells and mark for destruction by cell based immunity
Used in B cell Chronic Lymphocytic Leukemia
Auto immune - target T cell markers
Acquired immunity is reset
Aspirin
Non-selective COX inhibitor
NSAID - irreversible inactivation
Donate acetyl group to serine near COX active site
Effective in low doses at preventing platelet aggregation
Removes pro-coagulatory effect of TXA2 secreted by platelets
Can cause salicylate poisoning, Reyes syndrome
Azathioprine
Inhibit immune cell proliferation
Inhibit synthesis of guanine, and DNA synthesis
Limited to B and T cells, as others have salvage pathways
Celecoxib
COX-2 selective NSAID
Too bulky to enter COX-1 channel
Do not inhibit prostanoid synthesis
Cimetidine
H2 selective antagonist
Treat gastric ulceration
Reduces gastric acid secretion
Clarithromycin
Antibiotic to treat Helicobacter Pylori
Cyclosporin
Calcineurin inhibitors, inhibit T cell proliferation
Inhibit early activation
Inhibit secretion of IL2
Dexamethasone
Long acting >48hrs clinically used corticosteroid
Dimenhydrinate
H1 antagonist
Limited use as antihistamine
CNS side effects - used to treat motion sickness
Ibuprofen
Reversible NSAID
Non-selective
Compete with arachidonic acid for binding COX enzymes
Infliximab
Monoclonal antibody to control inflammation
Targets (bind and sequesters) TNFa
Rheumatoid arthritis, Crohns disease
Ipratropium
Muscarinic antagonist
Asthma and respiratory diseases
Loratidine
3rd generation antihistamine (H1 antagonists)
Few CNS affects and no affect on heart
Methotrexate
Disease modifying anti-rheumatoid drugs
Inhibits folate biosynthesis, thymidine availability and DNA replication
Antiproliferative
used in cancer chemotherapy
Metoclopramide
D2 antagonist
anti-emetic
Mycophenolate
Autoimmune/prevent organ rejection
Inhibit immune cell proliferation
inhibit synthesis of guanosine and therefore inhibit DNA synthesis
The effect is limited to B, T cell proliferation
because other cells possess an alternative salvage pathway for guanosine synthesis
Omalizumab
Monoclonal targeting IgE
IgE mediated asthma
Omeprazole
Proton pump inhibitor
Reduce gastric acid secretion
Ondansetron
5-HT3 antagonist
anti-emetic
Paracetamol
Non-selective COX inhibitor
May act on COX-3 - CNS specific cyclo-oxygenase
Little anti-inflammatory effect
Prednisolone
Short acting (<24hrs) corticosteroid Prednisone is precursor
Ranitidine
H2 selective antagonist
Treat gastric ulceration
Reduces gastric acid secretion
Scopolamine
Muscarinic antagonist
Anti-emetic
Sirolimus
Autoimmune disease and prevent organ rejection
mTOR inhibitor (mammalian target of rapamycin) inhibitor
Blocks late activation of T and B cells
Sulfasalazine
Interfere with lymphocyte behaviour
Treat rheumatoid arthritis
Sumatriptan
5-HT1D agonist
Suppress migraine
NSAID (triptan)
Terminate an attack
Tacrolimus
Autoimmune/prevent organ rejection
Calcineurin inhibitor - prevent T cell proliferation
Inhibit secretion of IL2
Zafirlukast
Maintenance treatment of asthma
specific cysteinyl leukotriene receptor antagonists
D4 and E4 receptor antagonist
Zileuton
Maintenance treatment of asthma
Inhibitor of 5-lipoxygenase
Inhibit synthesis of leukotrienes
