2

Question 1

glaucoma

Answer 1

=retinal damage and blindness

Question 2

muscarinic receptor activation side effects

Answer 2

• bradycardia and hypotension

- urinary and fecal continence etc etc

Question 3

nicotinic receptor activation side effects

Answer 3

• CNS
• autonomic ganglia
• NMJ: skeletal muscle “weakness”

Question 4

cholinesterase inhibitor (anticholinesterase)
reversible non substrate

Answer 4

edrophonium

Question 5

edrophonium

Answer 5

• ionized
• short acting (rapidly eliminated)
• uses: myasthenia gravis, w/ atropine reduce effects at muscarinic sites

Question 6

myasthenia gravis

Answer 6

= muscle weakness

• loss of NM receptors from muscle fibers
• dec transmission between motor neuron and muscle fiber

Question 7

cholinesterase inhibitor (anticholinesterase)
reversible substrate

Answer 7

carbamates

• physostigimine
• pyridostigmine
• tacrine
• donepezil

-all non ionized

Question 8

physostigimine

pyridostigmine

Answer 8

uses:

• GI and UB atony
• glaucoma
• atropine poisoning
• reversal of M and NM antagonist effect
• myasthenia gravis

Question 9

tacrine

donepezil

Answer 9

uses:

-alzheimer’s disease

Question 10

neostigmine

Answer 10

-ionized
-uses: same as physostigmine
(does not enter CNS ;] )

Question 11

cholinesterase inhibitor (anticholinesterase)
irreversible, substrate

Answer 11

echothiophate
malathion
parathion
sarin

• all non ionized
• side effects: muscle weakness and fatigue, autonomic signs (parasympathetic activation to organs)

Question 12

echothiophate

Answer 12

cholinesterase inhibitor (anticholinesterase)
irreversible, substrate
-uses: glaucoma

Question 13

malathion

parathion

Answer 13

cholinesterase inhibitor (anticholinesterase)
irreversible, substrate
-uses: insecticide

Question 14

sarin

Answer 14

cholinesterase inhibitor (anticholinesterase)
irreversible, substrate
-uses: nerve gases