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HEMA 2 > 1st Lecture - Prelim > Flashcards

1st Lecture - Prelim Flashcards

1
Q

defined as a method for controlling infection

A

Universal precaution

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2
Q

defined as all blood and certain body fluids are treated as if infected with hepa B, HIV, or disease-producing blood-borne pathogens

A

Universal precaution

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3
Q

Biohazard waste bin is in color?

A

yellow

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4
Q

sharps waste bin is in color?

A

red

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5
Q

helps in diagnosing bleeding disorder

A

platelet count

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6
Q

platelet functions?

A
  1. Primmary hemostasis
  2. Maintaning Capillary integrity
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7
Q

Platelet: Normal range?

A

150,000 - 450,000 /mm3

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8
Q

Largest hematopoietic stem cell in bone marrow

A

megakaryocyte

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8
Q

megakaryocyte maturations involves –?– where nuclear material reduplicates but nucleus does not divide

A

endoreduplication / endomitosis

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9
Q

platelets arise from what cell

A

megakaryocyte

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10
Q

carrier of CD34

A

progenitor cells

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11
Q

carrier of CD42

A

Terminal differentiation

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12
Q

3 progenitor cells

A
  1. BFU-Meg
  2. CFU-Meg
  3. LD-CFU-Meg
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13
Q

3 Terminal Differentiation Cells

A
  1. MK-I
  2. MK-II
  3. MK-III
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14
Q

Size: 20 - 50 um
Cytoplasm: non granular, small blunt pseudopods

A

Megakaryoblast

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15
Q

Size: 20 - 60 um
Cytoplasm: granules START to form
Nucleus: may show lobulation

A

Promegakaryocyte

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16
Q

Size: 30 - 90 um
Cytoplasm: finely and diffusely granular
Nucleus: multi-lobulation, chromatin is coarser, no nucleoli visible

A

Granular Megakaryocyte

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17
Q

Size: 40 - 120 um
Cytoplasm: course clumps of granules aggregating into little bundles which bud off (platelets)
Nucleus: multi-lobulation, no nucleoli visible

A

Mature Megakaryocyte

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18
Q

last stage of megakaryocytic series which has no visible nucleoli

A

Mature Megakaryocyte

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19
Q

stage of megakaryocytic series which granules begin to form

A

Promegakaryocyte

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20
Q

smallest among the stages of megakaryocytic series

A

Megakaryoblast

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21
Q

Product of the megakaryocytic series

A

platelets

22
Q

2 - 4 um

A

platelets

23
Q

cytoplasmic fragments of megakaryocyte

A

platelets

24
Q

Platelets survive within how many days

A

7-10 days

25
Q

1/3 of platelets are found in?

A

circulating pool

26
Q

2/3 of platelets are found in?

A

splenic platelet pool

27
Q

Anatomical parts of Platelet

A
  1. Peripheral zone
  2. Sol-gel zone
  3. Organelle zone
  4. Membranous system
28
Q

Platelet Normal function range:

A

> 100,000/uL

29
Q

Platelet hemorrhage range:

A

<10,000/uL

30
Q

platelet participate in hemostasis by providing negative charge phospholipid surface for ?

A

Factor V & Factor 2 Activation

31
Q

platelet participate in hemostasis by releasing substances that mediate ?

A

vasoconstriction, platelet aggregation, coagulation and vascular repair

32
Q

platelet participate in hemostasis by providing surface glycoproteins such as?

A

GP Ib and IIb/IIIa

33
Q

Peripheral zone is responsible for?

A

platelet adhesion and aggregation

34
Q

adhesion is?

A

attachment of platelets to the blood vessel

35
Q

aggregation is ?

A

attachment of platelets to each other

36
Q

The outer part of the Peripheral zone that is composed of glycoproteins

A

glycocalyx

37
Q

Glycocalyx is a Major GP responsible for?

A

Primary hemostasis

38
Q

A receptor for Von Willebrand factor responsible for platelet adhesion

A

GP Ib

39
Q

A receptor for Fibrinogen responsible for platelet aggregation

A

GP IIb/IIIa

40
Q

Parts of the Peripheral zone

A

glycocalyx, plasma membrane, and submembranous system

41
Q

Sol-gel zone is composed of

A

microfilament and microtubule

42
Q

Under microfilaments, the proteins found are responsible in creating contractile protein such as?

A

actomyosin or trombasthenin

43
Q

actomyosin or trombasthenin is important for clot —?

A

clot retraction

44
Q

it is composed of tubulin

A

microtubule

45
Q

protein tubulin maintains the —- of the platelet

A

shape

46
Q

Organelle zone is composed of?

A

mitochondria, alpha granules, & delta granules

47
Q

how many alpha granules is found per cell

A

50 - 80 per cell

48
Q

how many delta granules is found per cell

A

2 - 7 per cell

49
Q

It contains the ADP, ATP, Serotonin, Ca+ and Mg

A

Delta granules

50
Q

It contains Von Willebrand factor, factor 5, factor 4, etc

A

Alpha granules

51
Q

membranous sytem comprises of

A

Dense Tubular System and Open Canalicular System

52
Q

Dense tubular system is an endoplasmic reticulum that sequesters –?— for platelet activation

A

calcium

53
Q

Open Canalicular System is the —?— of the plasma membrane for release of granule content during platelet activation

A

invagination

HEMA 2 (2 decks)

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