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310 Pharm > 1st Exam > Flashcards

1st Exam Flashcards

1
Q

What is enteral administration?

A

Into the GI tract-oral, rectal, NG tube, etc. Most drugs absorbed in small intestine.

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2
Q

What is sublingual admin?

A

Placed under the tongue. Absorbed in capillaries, bypasses liver and gastric secretions. Enhanced potency.

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3
Q

What is buccal admin?

A

Placed between cheek and gum. Absorbed in capillaries, bypasses liver and gastric secretions. Enhanced potency.

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4
Q

What is topical admin?

A

Placed directly onto the skin. Transdermal. Absorbed through skin into blood stream.

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5
Q

What is parenteral admin?

A

Injection. Most dangerous as meds act quickly. Dosage accuracy and aseptic technique required.

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6
Q

Types of parenteral admin?

A

Intradermal, subcutaneous, intermuscular, intravenous, intraarterial

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7
Q

What is inhalation admin?

A

Oxygen, inhalers, etc.

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8
Q

What does pharmacology mean?

A

Study of drugs in living systems

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9
Q

Difference in ‘medication’ vs ‘drug’?

A

Medication: substances prescribed for a treatment that produces therapeutic effects.
Drug: chemical substance that produces a biologic response in a living system

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10
Q

Intradermal?

A

Injected into dermis (just under skin), creates wheal (bump)

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11
Q

Subcutaneous?

A

Injected into subcutaneous layer at 45 degree angle

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12
Q

Intermuscular?

A

Injected into muscle at 90 degree angle

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13
Q

1938

A

Federal Food, Drug, and Cosmetic Act required accurate labels of ingredients and warning labels. FDA created.

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14
Q

1970

A

Controlled Substances Act set controls on abusive drugs. DEA established.

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15
Q

1990

A

Omnibus Budget Reconciliation Act (OBRA) mandated all OTC drugs be listed in patient’s charts. Pharmacists must provide drug review and patient counseling for new prescriptions.

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16
Q

What is drug classification?

A

Name
Mode of action
Whether prescription or OTC (how purchased)

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17
Q

Controlled substance classifications.

A

1-5, 1 most dangerous (Heroin, LSD). Labeled as CI, CII, etc.

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18
Q

Legal prescription must have included:

A 
Patient info
Drug name
Dosage in proper units
Dosage form
Route of admin
Date written
Prescriber info/signature
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19
Q

What is biopharmaceutics?

A

Interrelatedness of chemical properties of a drug with its dosage form, route, and extent of systemic absorption.

The study of the chemical and physical properties of drugs and the biological effects they produce.

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20
Q

What is the term used for how a drug is compounded for delivery to a targeted area of the body?

A

Drug vehicle

Vehicle must be able to release drug at appropriate site

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21
Q

What is the term used for when a drug and vehicle are combined and used to deliver the drug? What are the 3 types?

A

Dosage form

Solid, liquid, gas

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22
Q

Examples of solid dosage forms

A

Tablet - active ingredient, fillers, dyes, disintegrator (turn drug into solution), outside coating, enteric—release into small intestine

Capsule - gelatin shell to mask taste, control release

Troches - lozenges

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23
Q

Examples of liquid dosage forms

A

Solutions - homogenous; drug dissolved in solvent

Emulsions - immiscible liquids

Suspensions - solid medication dispersed in liquid medium

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24
Q

Parenteral dosage form examples

A

Sub Q
IM
IV
Intradermal

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25
Q

Examples of gas dosage forms

A

Oxygen therapy
Anesthesia
Aerosol inhalers

Usually liquid medication in gas propellant- easily absorbed in lungs

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26
Q

What is disintegration?

A

Medication absorbed as liquid or gas
Solids must be liquefied before absorption
Ex: tablet into granules, into smaller particles, into solution, into absorption

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27
Q

What happens to the drug as it moves through the body?

A

Process of drug being absorbed, distributed, metabolized, eliminated

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28
Q

Effects of drugs

A

Cellular changes/drug actions
Physiologic changes/drug effects
-Systemic - reaches many areas of body
-Local - limited to administration area

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29
Q

Bioavailability

A

Proportion of administered drug that actually reaches systemic circulation (into blood stream)

Varies by: person, route, dose

Surface area available influences bioavailability
i.e. length of time for drug to reach destination

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30
Q

Influences of people processing drugs differently.

A 
Age( elderly & very young)
Nutritional status
Ethnicity
Existing physical condition (liver or kidney disease)
Immune status
Drug interactions
Administration route
State of mind
Gender 
Genetics 
Weight 
Environmental factors
Time of day
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31
Q

Influences of people processing drugs differently.

A 
Age( elderly & very young)
Nutritional status
Ethnicity
Existing physical condition (liver or kidney disease)
Immune status
Drug interactions
Administration route (injection faster than tablet)
State of mind
Gender 
Genetics 
Weight 
Environmental factors
Time of day
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32
Q

Systemic absorption locations

A 
(Administration site to blood stream)
Locations of absorption:
GI tract
Lungs
Mucous membranes
Eyes
Skin
Muscle
Subcutaneous fat/tissues

Chemical properties of drug & vehicle must be compatible

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33
Q

Factors influencing absorption

A

Surface area - more surface area = better absorption (GI tract vs. pulmonary alveoli)
Blood flow- blood must get to absorption site (ruggae, alveoli highly vascular) (poor circulation can slow absorption)
Altered blood flow reduces absorption
Concentration- most drugs passive transport thru membranes (high concentration to low concentration) [some active transport (drug attaches to carrier protein, protein takes drug across membranes)]

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34
Q

Absorption factors (chemically)

A 
Acid-base/pH
Most drugs weak acid or weak alkaline
Acid = stomach absorption
Alkaline = small intestine absorption
Neutral pH best for absorption
Neutral charge = better absorption

Drugs easily pass through barriers similar of pH

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35
Q

What is lipophilicity and what does it do?

A

Ability of drug to dissolve in lipids

Allows for cross through lipid layers
Must still dissolve in water
Easily absorbed through stomach mucosa
Alcohol & drugs with alcohol are lipid soluble
Just water soluble drugs don’t pass through
Give by other routes-ex IV

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36
Q

What is lipophilicity and what does it do?

A

Ability of drug to dissolve in lipids (fats)

Allows for cross through lipid layers
Must still dissolve in water
Easily absorbed through stomach mucosa
Alcohol & drugs with alcohol are lipid soluble
Just water soluble drugs don’t pass through
Give by other routes-ex IV

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37
Q

Affects food in stomach has on absorption factors

A

Can slow drug absorption (why “take on empty stomach”)

Can buffer effects of stomach irritating drugs (why “take with food”)

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38
Q

What is the chelation effect?

A

Compatibility with other drugs
If two drugs combine and form precipitate, absorption is diminished which is Chelation effect
Ex: Tetracycline + milk/dairy/antacids (Ca++) = insoluble complex
(Doesn’t help you, they bind together)

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39
Q

What is passive transport?

A 
Drug moves through cell membrane by diffusion
High to low concentration
Once equal, no more diffusion
Lipid solubility most important factor 
(Passive occurs most often)
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40
Q

What is active transport?

A

Requires energy from cell and carrier molecule
Enzyme or protein combines with drug molecule on membrane surface; carries it through, then dissociates

Pinocytosis: cell engulfs drug particle in membrane , pulls into cell, and releases it

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41
Q

At what location in circulatory system will the drug get to its target?

A

At capillaries and across membranes

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42
Q

Drug passes through stomach mucosa/cell membranes via _____ or ______ transport.

A

Active, passive

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43
Q

Drug travels to the action site through ___

A

The bloodstream

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44
Q

Once the drug arrives at the action site, it gets into the target tissues by passing _____

A

Through cell membranes

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45
Q

What is selective distribution?

A

Specific properties of drug affect movement (same properties, different distribution rate)
Some drugs have affinity for certain organs/cells (human chorionic gonadotropin targets ovaries-where absorbed)
Lipophilicity affects movement to target tissue
Blood-brain barrier
Placental barrier

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46
Q

Factors affecting distribution

A 
Cardiac output (amount of blood pumped per minute)
Regional blood flow (blood  supply to specific organ or tissue)
Drug reservoirs (specific sites that hold drugs. Ex:  plasma, fat tissue, bone)

Plasma proteins - drug binding to this inactivates the drug (free drugs, once used cause bound drugs to become free)

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47
Q

Distribution barriers

A

Blood-brain - drugs meant to cross must be lipid soluble, minimally binding to plasma

Placenta - not selective, lots of drugs can pass, first trimester most important

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48
Q

Metabolism of drugs

A

Chemical changes to drugs (change drug from fat soluble to water soluble-metabolite excreted)
Liver primary organ (also: kidneys, lungs, intestinal mucosa, plasma)
Types of chemical changes:
-Oxidation, hydrolysis, reduction (gain an e-)
-Conjugation (transform from lipid soluble to water soluble. Excrete thru biliary tract and/or kidneys)

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49
Q

Abnormal drug metabolism

A

Prolonged by: liver disease, cardiovascular disease, renal problems (won’t excrete properly), immature metabolizing enzyme systems (children), degenerating enzyme function (not able to process drugs).

Delay in excretion can mean overdose

First pass phenomenon: oral drug goes through liver first before general circulation. Drug can deteriorate before reaching general circulation if liver disease is present-less effective

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50
Q

First Pass Effect

A

PO drug: mouth—stomach—small intestine—mesenteric vascular system—portal vein—liver—systemic circulation.

Some of drug metabolized through this process, loses effectiveness- partial metabolism
May require higher dose of an oral drug

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51
Q

Methods that avoid first pass effect

A

Sublingual
Vaginal
Parenteral (water soluble)
Rectal

(Think water and oil-don’t want oil (lipids/fats) in your blood stream-could cause embolism)

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52
Q

Enterohepatic Recycling

A

Certain drugs once absorbed, move from bloodstream to liver, then through biliary tract.
Excreted in bile OR return to small intestine and back into bloodstream
Result: drug stays in body for a long time (risk of toxicity)

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53
Q

Half-life

A

Time it takes for presence of drug in the body to decrease by 50%
Influences frequency of administration in order to keep plasma levels even

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54
Q

Clearance Rate

A

How long it takes for a drug to completely leave body.

Slow clearance rate runs risk of drug toxicity

55
Q

Excretion

A

Kidneys: Most drugs excreted (unbound, water-soluble molecules. Drug molecules, intact/metabolized pass through kidneys, filtered out)

Intestines: metabolite (drug that was metabolized) excreted into bile, passes through intestines to feces

Respiratory system: if inhaled usually exhaled

Tertiary: breast milk, sweat, saliva (not as common)

56
Q

Complications of delayed excretion

A

Cumulative effect: delayed excretion & additional doses, concern with decreased kidney function, elderly

Toxicity: dangerous amount of drug

57
Q

A drug _____ is a substance into which a drug is compounded for primary delivery into the body.

A

Vehicle

58
Q

A combination of the active drug and the vehicle used to deliver the drug is called:

A

Dosage form

59
Q

Word meaning within the GI tract:

A

Enteral

60
Q

The medical abbreviation for the oral method of drug administration:

A

PO

61
Q

This enteral route involves the drug being taken by the mouth and swallowed:

A

Oral

62
Q

This enteral route involves the drug administered under the tongue:

A

Sublingual

63
Q

This enteral route involves the drug administered between the cheek and gums:

A

Buccal

64
Q

The enteral route that bypasses the mouth and intestines and is used when the patient cannot take a drug orally:

A

Rectal

65
Q

Drug administration route in which the drug is applied directly to the skin or mucous membrane, where it diffuses through the skin and into the bloodstream:

A

Topical

66
Q

A topical method of drug delivery that is not a lotion, foam, spray, gel, or ointment:

A

Transdermal patch

67
Q

This enteral route allows for rapid absorption and immediate onset of the drug:

A

Sublingual

68
Q

The medical abbreviation for every hour:

A

Qh

69
Q

This dosage form can be sugar-coated, compressed, film-coated, enteric-coated:

A

Tablet

70
Q

This type of coating is designed to pass through the stomach and release the medication into the small intestine:

A

Enteric coated

71
Q

Name three drug delivery forms:

A

Solid, liquid, gas

72
Q

Solid form of medication delivery that makes it easier to swallow, masks taste, and controls the release of the medicine:

A

Capsules

73
Q

A medical term for lozenge:

A

Troche

74
Q

Includes suspensions, emulsions, and solutions as a dosage form:

A

Liquid

75
Q

A homogenous mixture of solid, liquid, or gas dissolved in another liquid:

A

Solution

76
Q

Dosage form with two immiscible liquids:

A

Emulsion

77
Q

A solid medication dispersed in a liquid medium is called a:

A

Suspension

78
Q

General term for a medication delivery route that involves injection through layers of skin or mucous membranes:

A

Parenteral route

79
Q

A drug administered by any route other than the GI tract:

A

Parenteral route

80
Q

A parenteral route in which the medication is injected into the connective tissue under the dermis:

A

Subcutaneous

81
Q

A parenteral route in which the medication is injected into the subdural, arachnoid, or lumbar areas:

A

Intrathecal

82
Q

A parenteral route in which the medication is injected into a joint space:

A

Intraarticular

83
Q

Which is the only type of joint into which medications can be injected

A

Synovial

84
Q

Injection into the space outside the dura mater:

A

Epidural

85
Q

Space in the spine into which contrast media is injected:

A

Subarachnoid

86
Q

Parenteral administration of medications requires adherence to ____ technique

A

Aseptic

87
Q

When administering a drug via the parenteral route, what type of precautions must be taken?

A

Standard precautions

88
Q

Common IM injection site in the arm:

A

Deltoid muscle

89
Q

Common IM injection site in the leg:

A

Vastus lateralis muscle

90
Q

Common IM injection site in the torso

A

Gluteus maximus

91
Q

An IM injection is performed at a ___ degree angle to the body part

A

90

92
Q

A Sub Q injection is performed at a ____ degree angle to the body part

A

45

93
Q

Sub Q injections are absorbed at a faster or slower rate than IM injections?

A

Slower

94
Q

A method of IV medication administration in which a single dose of medication is administered at one time or as a ____

A

Bolus

95
Q

This method of IV medication administration involves the administration of a large amount of fluid over a period of time

A

Drip infusion

96
Q

What are the five “rights” of drug administration?

A

Right patient, route, time, drug, dose.

97
Q

How many times do you read the medication vial label before administering a drug/medication?

A

3

98
Q

The first time I read a medication label is:

A

When removed from shelf

99
Q

The second time I read a medication label is:

A

Removing drug from container

100
Q

The third time I read a medication label is:

A

When the container is replaced on the shelf/when the Md begins to administer the drug

101
Q

When you take a drug out of the cabinet to prepare it for use, what else do you check besides the name of the drug?

A

Expiration date

102
Q

When taken orally, where are most drugs absorbed?

A

Small intestine

103
Q

When given orally, drug effects generally take effect more ____ and ____ ______ than when given parenterally

A

Slowly, less efficently

104
Q

The advantage of the sublingual route is that the drug is absorbed directly into the capillaries and bypasses the:

A

Liver

105
Q

Sublingual administration also prevents the drug from being affected by what aspect of the GI tract?

A

Gastric and intestinal enzymes

106
Q

Topical absorption of medicines is increased when the patient’s skin is:

A

Thin

107
Q

Which of these absorb drugs more readily: skin or mucous membranes?

A

Mucous membranes

108
Q

Topical absorption of a drug can be increased when there is ______ drug concentration.

A

Increased

109
Q

This type of IV catheter is used to administer drugs, manage fluid volume, transfuse blood, take blood samples, monitor blood pressures or pressure in the heart.

A

Central venous line

110
Q

The tip of central venous lines are usually positioned here:

A

Superior vena cava

111
Q

Where in the SVC are central lines usually located?

A

2-3 cm above the right atrial junction

112
Q

What gas is commonly prescribed as a medicine?

A

Oxygen

113
Q

This is a common method by which gaseous medicines are delivered:

A

Aerosol inhalers

114
Q

Antiarrhythmic

A

Cardiac medications that block the electrical system of the heart, specifically the SA node, AV node, and bundle of His-all to decrease arrhythmias of the heart.

Examples: atenolol, metoprolol, digoxin

115
Q

Antihypertensive

A

Cardiac medications that lower blood pressure which in turn decrease the pressure that a heart pumps.

Examples: amlodipine, lisinopril, valsartan, spironolactone.

116
Q

Diuretics

A

Cardiac-(aka water pills) eliminate excess fluid and sodium from the bloodstream. This helps with edema as well as other ailments.

Examples: hydrochlorothiazide, furosemide, metalozone

117
Q

Anticoagulant

A

Medications that help with patients who have a history or potential to develop blood clots.

Examples: heparin, enoxaparin, bivalirudin

118
Q

Antiplatelet

A

Medication that helps patients who have a history of an ischemic event to their heart or brain. The antiplatelet medication helps stop the excessive formation of platelets in those areas.

Examples: aspirin, clopidogrel, dipyridamole

119
Q

Thrombolytic

A

Medication that breaks up clots in the bloodstream due to stroke, MI, or lower leg ischemia. Patients who take this medication are at risk of excessive bleeding internally and externally.

Examples: urokinase, retaplase, alteplase

120
Q

Narcotic

A

ANALGESIC- Narcotic medications are high dose pain killers that have a potential for addiction.

Examples: hydrocodone, oxycodone, tramadol, morphine, butorphanol

121
Q

Nonsteroidal anti-inflammatory (NSAIDS)

A

ANALGESIC- Nonsteroidal anti-inflammatory (NSAIDS) treat pain related to inflammation.

Examples: ibuprofen, naprozen, ketorolacc, indomethacin

122
Q

Muscle relaxants

A

ANALGESIC-Muscle relaxants treat pain related to muscle spasms.

Examples: cyclobenzaprine, diazepam, lorazepam, clonazepam

123
Q

Antihistamines

A

Antihistamines block histamine production that causes itching, inflammation, and other allergic reactions.

Examples: hydroxyzine, diphenhydramine, loratadine, cetirizine

124
Q

Antidiabetic

A

ENDOCRINE-Antidiabetic medication help those who have trouble balancing blood sugars. Type 1 DM are insulin dependent, while Type 2 DM are non-insulin dependent.

Examples: metformin, glipizide, glyburide, pioglitazone

125
Q

Thyroid

A

ENDOCRINE-Thyroid medication treats hypothyroidism and can either enhance or block thyroid functions.

Examples: levothyroxine, thyroxine, methimazole, propylthiouracil

126
Q

Antiseizure

A

CENTRAL NERVOUS SYSTEM-Antiseizure (anticonvulsant) medications prevent, prolong the intervals between seizures, and treat seizure disorders.

Examples: diazepam, clonazepam, phenobarbital, phenytoin

127
Q

Antipsychotic

A

CENTRAL NERVOUS SYSTEM-Antipsychotic medications help to treat psychotic events such as hallucinations, bipolar/manic, schizophrenia, etc.

Examples: clozapine, haloperidol, divalproex, olanzapine

128
Q

Antidepressant

A

CENTRAL NERVOUS SYSTEM-Antidepressant medications treat clinical depression from neurotransmitter deficiencies.

Examples: amitriptyline, citalopram, buproprion, trazadone, imipramine

129
Q

Antianxiety

A

CENTRAL NERVOUS SYSTEM-Antianxiety medications treat anxiety.

Examples: diazepam, lorazepam, clonazepam, midazolam

130
Q

Antibiotic

A

ANTI-INFECTIVE -Antibiotic medications kill or suppress microorganisms responsible for infectious diseases.

Examples: penicillins, cephalosporins, ampicillin, cefurozine, tetracycline, clindamycin

131
Q

Antifungal

A

ANTI-INFECTIVE -Antifungal medications kill fungal organisms.

Example: fluconazole, clotrimazole, nystatin

132
Q

Antiviral

A

ANTI-INFECTIVE -Antiviral medications suppress and stop the spread of viruses in the human body.

Example: acyclovir, ribavirin, valacyclovir, interferon

133
Q

Chemotherapy

A

Chemotherapy medications are toxic compounds that stop the growth of cancerous cells in the body.

Examples: flurouracil, paclitaxel, bleomycin, etoposide

310 Pharm (2 decks)

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