1.Fracture biomechanics Flashcards
what is inorganic osteoid?
unmineralized bone made by osteoblast
osteoclast develops from which lineage?
monocytes
Describe an osteoclast
large, multinucleated cell
responsible for bone resorption
produce acid locally which helps with bone resorption
what makes up the organic ECM?
type 1 collagen and some ground substance such as proteoglycans
Know the macroscopic anatomy of the bone
-epiphysis
-metaphysis
-diaphysis
epiphysis is mostly cartilage- at the articular surfaces
where is cortical bone found
cortical bone aka compact bone is found at the shaft of long bones
what are some properties of cortical bone? density? cellularity?
how does it develop?
cortical bone is acellular and highly dense
it develops in proportion to stress
bone surrounds blood
where is trabecular bone found?
found on long bones, axial skeleton
its on the ends of the long bones
very porous, rich in nutrients/blood
blood surrounds bone
what connects the periosteum to the cortical bone?
sharpeys fibers
ECM made up of organic and inorganic substance, what are they
organic- type 1 collage
inorganic-hydroxyapatite
hydroxyapatite is laid down by ___ as ______
how Is it mineralized?
osteoblast as unmineralized osteoid
alkaline phosphatase -enzyme
What is significant about the primary and secondary ossification centers in relation to bone fractures
this is at the site of the growth plate/physis
this is usually where the bone fractures occur bc its the weakest area, and specifically at the zone of hypertrophy
what are some functions of bones
protective- ribs and skull
movement- muscles attach to it
shape- provides the body with a figure
blood cell production- BM RBC/WBC
IO vs EO
intramembranous ossification: no cartilage template
EO- endochondral ossification has a cartilage intermediate
what is an osteon, where is it found
its mineralized osteoid that becomes osteon
-this is cortical bone
is found at the metaphysis and diaphysis, its strongest at the diaphysis