14. bone graft Flashcards

1
Q

explain the different mechanisms of bone healing

A

EO- endochondral ossification, cartilage template, found in long bones
IO-intramembranous ossification - flat bones, skull

cutting cones- makes the canaliculi- occurs in primary fracture/bone healing and remodeling

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

examine different types and functions of bone grafts

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

demonstate clinical assessment of bone healing

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

osteoblast
produce
derived from
turn into

A

produce osteoid
MSC
turn into osteocytes once trapped in lacunae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

osteoclast
derived from

A

activity is painful
resorb/destroy bone
hematopoietic stem cell
enzymatic breakdown of osteoid
multinucleated cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

primary vs secondary osteon form

A

osteon- found in cortical bone/lamelar bone

primary- during primary bone growth/development
osteoblast laying down osteoid

secondary-during remodeling- cutting cones, osteoclastic resorption activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

cutting cones

A

osteoclast resorbing bone and osteoblast following behind
occurs during primary bone repair/healing and remodeling

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

IO- intramembranous ossification

this increase the width of the bone

A

found in flat bones, inner and outlayer of long bones (periosteum/endosteum)
osteoblast differentiate from progenitor cell and lay down osteoid- do not need cartilage template

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

IO increases the ___ of bone
EO increases the ___ of bone

A

IO- width
EO- the length

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

EO- endochondral ossification

A

its a cartilage precursor

chondrocyte-zone of hypertrophy -calcification

increases LENGTH of bone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

prerequisites for bone healing

A

-rigid stabilization ( <2% strain)
-blood supply
-no infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

goals of stabilization

A

decrease interfragmentary strain

decrease fracture gap

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

direct bone healing/primary bone healing

A

< 1mm gap
cutting cones
no callus forms
needs rigid stability
secondary osteon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

indirect healing/secondary

A

will form a callus
both EO and IO
less stable, callus helps stabilize a fracture
inflammation–>callus–>remodeling

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

osteogenesis

A

osteoblast in bone material contribute to new bone growth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

osteoinduction

A

bone graft recruits osteoprogenitor cells and induced the formation of new bone

17
Q

osteoconduction

A

bone graft serves as a scaffold for osteoprogenitor cells

synthetic bone grafts are osteoconductive

18
Q

osteopromotion

A

enhances osteoinduction production without osteoinduction properties

19
Q

bone graft indications

A

speed healing, promote healing of infected areas and non-union

enhances healing and helps with bone loss

20
Q

autograft

A

graft from self

21
Q

allograft

A

graft some another animal

22
Q

xenograft

A

graft from a different species

23
Q

types of bone grafts

A

cancellous/spongy/trabecular bone

cortical/lamellar bone

corticocancellous

mineralized bone matrix

synthetic bone graft

24
Q

cancellous bone graft

A

autogenous is the GOLD standard

osteogenesis-osteoblast comes
osteoinductive - recruits progenitor cells
osteoconductive- scaffold for osteoprogenitor cells

25
cortical bone graft
mechanical support osteoconductive- scaffold for osteoprogenitor cells
26
harvesting cancellous bone graft
aseptic prepare surgical site in advance drill hole, collect cancellous bone
27
cancellous donor sites for large animal
ilium sternum
28
cancellous donor site for small animal