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Neuro B3 - Basal Gang + Parkinsons > 1f Basal Ganglia - neurotransmitters > Flashcards

1f Basal Ganglia - neurotransmitters Flashcards

1
Q

What neurotransmitter is released by the striatum? To what structures?

A

GABA - to GPe/GPi & GABA to Substantia Nigra Pars Reticulata

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2
Q

What neurotransmitter is released by the Globus Pallidus external? To what structure?

A

GABA to Subthalamic Nucleus

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3
Q

What neurotransmitter is released by the Globus Pallidus internal? To what structure?

A

GABA to Thalamus

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4
Q

What neurotransmitter is released by the Subthalamic Nucleus?

A

Glutamate to GPi

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5
Q

What is the GPi normally doing to the Thalamus?

A

tonic inhibition

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6
Q

What is the GPe normally doing to the Subthalamic Nucleus?

A

tonic inhibition

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7
Q

What is the Substantia Nigra Reticulata normally doing to the Superior Colliculus?

A

tonic inhibition

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8
Q

What neurotransmitter does the Substantia Nigra Pars Reticulata release? To what?

A

GABA to Superior Colliculus & Thalamus

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9
Q

What neurotransmitter does the Substantia Nigra Pars Compacta release? To what?

A

Dopamine to Striatum

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10
Q

What neurotransmitters are Striatum interneurons secreting?

A

Acetylcholine

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11
Q

What is the Direct Pathway?

A

corticostriatal cells –> striatum –> GPi : disinhibition of thalamus & movement is initiated

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12
Q

What is the Indirect Pathway?

A

corticaostriatal cells –> striatum –> GPe : disinhibition of Subthalamic Nucleus –> GPi : inhibition of Thalamus

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13
Q

What is the Nigrostriatal Pathway?

A

SNcompacta –> striatum –> [direct pathway] (GPi : disinhibition of thalamus & movement initiated)

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14
Q

What is the Striatonigral Pathway?

A

cortocstriatal cells –> striatum –> SNr : Disinhibition of Superior Colliculus resulting in saccadic eye movement (rapid, jerky eye movement)

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15
Q

What is the Hyperdirect Pathway?

A

corticostriatal cells –> subthalamic nucleus –> GPi : inhibition of Thalamus (enhancing indirect pathway)

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16
Q

What does the direct pathway do?

A

initiate movement

17
Q

What does the indirect pathway do?

A

inhibit movement

18
Q

What does the nigrostriatal pathway do?

A

lowers threshold fo rmovement

19
Q

What does the striatonigral pathway do?

A

control saccadic eye movement

20
Q

What does the hyperdirect pathway do?

A

facilitates indirect pathway

Neuro B3 - Basal Gang + Parkinsons (8 decks)

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