1.8 CJD

Question 1

Creutzfeldt Jakob Disease

Decontamination process

Answer 1

1. Cleaning
2. Disinfection
3. Sterilisation

Question 2

1. Cleaning

Answer 2

Removal debris
washing detergent
rinsing
drying

optimise effectiveness of disinfection / sterilisation

Question 3

2. Disinfection

Answer 3

Use sub
2% Chlorhex
in 70% alcohol or Na hypochlorite

kills most

bacteria (not endospore / TB)
Fungus

Further disinfection aldehydes
more effective
produce sterilisation over longer period

Question 4

3. Sterilisation

Answer 4

eg Autoclave

remove all bacteria virus spore fungus

Question 5

CJD`

Answer 5

Transmissible spongiform encephalopathy

abnormal infectious prion protein

divided:
sporadic
hered
acquire

Acquire cases
contam surgical equip / tissue transplantation (cornea / dura IgG)

Question 6

CJD

symp
Dx

Answer 6

characterised progressive fatal neurolg deterioration

neuropsych
cerebellar sym
sticky skin ~ unusual sensory symp

MRI
eeg
tonsillar bx
csf

Question 7

Minimising Intraop tmission

Answer 7

1. Standard infection control precautions
2. Asepsis invasive
3. ID of tissue @ increase risk
   tonsils adenoid post eye
4. Communication w/ haem + micro regard mx and protein tissue and blood specimen
5. equip in contact w/ high rsik tissue
   brain s/cord -
   quarantined or destroyed after use
   = laryngoscopes
6. Airway equip for tonsils / adenoid thrown away post op
7. disposable equipment encourage reliable + economically possible
8. reusable tracing

Question 8

CJD reduce w/ blood products

Answer 8

1. Min use blood production
2. leucodepletion white cell
3. majority plasma outside UK