17 Glaucoma Williams

Question 1

What are the two first choice classes for Glaucoma?

Answer 1

Prostaglandin Analogs or B-Blocking Agents

Question 2

When are Prostaglandin Analogs usually dosed?

Answer 2

QHS

Question 3

What is the primary indication for Prostaglandin Analogs?

Answer 3

Primary Open-Angle Glaucoma (POAG)

Question 4

When are Prostaglandin Analogs contraindicated?

Answer 4

Closed Angle Glaucoma

Question 5

What are some of the Prostaglandin Analogs used?

Answer 5

TafluPROST, BimatoPROST, LatanaPROST, TravoPROST, UnoPROSTone

Question 6

What are the more common ADRs with Prostaglandin Analogs?

Answer 6

Burning, dry eyes, itching. Increased length of eyelashes. Iris pigmentation. Conjunctival hyperemia (Tafluprost)

Question 7

How often are B-Blocking Agents usually dosed?

Answer 7

Typically given Q12h

Question 8

What are the B-1 Selective agents usually used?

Answer 8

LevobetaxOLOL (Betaxon), BetaxOLOL (Betoptic)

Question 9

What are the Non-Selective B-Blocking Agents used?

Answer 9

CarteOLOL, LevobunOLOL, MetipranOLOL, TimOLOL

Question 10

How do the alpha/beta Agonists work?

Answer 10

Increased outflow through trabecular meshworks

Question 11

What are the alpha/beta Agonists used?

Answer 11

Dipivefrin (Propine) given Q12h, not very effective

Question 12

How do alpha-2-Adrenergic Agonists work?

Answer 12

Decrease aqueous production

Question 13

What are the alpha-2-Adrenergic Agonists used?

Answer 13

ApracloNIDINE (Iopidine), BrimoNIDINE (Alphagan)

Question 14

How do Cholinergic Agents work?

Answer 14

Increase trabecular outflow

Question 15

What are the Cholinergic agents used?

Answer 15

Pilocarpine, Carbachol, Echothiophate

Question 16

What are the best agents for lowing IOP?

Answer 16

Carbonic Anhydrase Inhibitors

Question 17

When are Carbonic Anhydrase Inhibitors usually used?

Answer 17

3rd line. Prostaglandin or B-blocker first line, then combo, then this

Question 18

What is the better route for Carbonic Anhydrase Inhibitors administration?

Answer 18

Topical less effective than oral (but oral can cause acidosis, diuresis, or hyperuricemia)

Question 19

What are the Oral Carbonic Anhydrase Inhibitors used?

Answer 19

Methazolamide (most common), Acetazolamide

Question 20

What are the sol/susp Carbonic Anhydrase Inhibitors used?

Answer 20

Brinzolamide, Dorzolamide

Question 21

What drug has a high risk of potentiating Glaucoma?

Answer 21

Corticosteroids