17 Aging and Development Flashcards
Fertilization
The union of egg and sperm (ovum, ova) to form a zygote
Zona Pellucida
outer matrix surrounding the egg
Corona Radiata
outside the zona pellucida are few residual follicular cells from the ovarian follicle, called the corona radiata
Steps of Fertilization
- several sperm penetrate the corona radiata (but not the zona pellucida. First sperm to penetrate the zona pellucida triggers changes in the zona so others cant get in
- Sperm’s acrosomal enzymes digest a portion of the zona pellucida
- one sperm binds to and fuses with the egg’s plasma membrane
- sperm nucleus enters the egg
What prevents more than one sperm from entering the egg?
- The egg’s plasma membrane depolarizes from 265mv to 10mv, which helps prevent more sperm from attaching to the egg.
- Vesicles (cortical granule) within the egg releases enzymes that causes the zona pellucida to become impenetrable to other sperm
Development of embroyo after sperm and egg nuclei fuse
- Cleavage: cells undergo division (2,4,8, etc) without the embryo increasing in size
- Growth: cells continue to undergo division and size of embryo increases
- Morphogenesis: the embryo begins to take shape as cells migrate to specific locations
- Differentiation: cells take on specific structure and function (the nervous system is the first visible system fomed)
Extra-embryonic Membranes
- Chorion: forms the placenta, the organ that provides the embryo with nourishment and oxygen and rids it of waste
- Allantois: give rise to the urinary bladder, and the blood vessels of the umbilical cord that carry blood between the fetus and placenta
- Yolk sac: contains many blood vessels and where blood cells first form (there is a little yolk in humans, in contrast to eggs of other animals)
- Amnion: contains amniotic fluid that surrounds, cushions, and protects the embryo
Stages of Development
- pre-embryonic development - from moment of egg fertilization until end of 1st week
- embryonic development - from begin of 2nd week after fertilization until the end of the 2nd month
- fetal development - the 3rd throught the 9th month of development
- development after birth - stages of life including infancy, childhood, adolescence and adulthood
Pre-embyonic development
(1st week of development after fertilization)
- Cleavage: cell division that incrases the number of cells
- Morula: compact ball of embryonic cells
- Early blastocyst: inner cell mass that becomes the embryo covered by a layer of cell that becomes the chorion
- Implantation: embyo embeds into the uterine endometrial lining on approximately day 6 after fertilization
Embyonic Development: Week 2
- Pregnancy begins after implantation of fertilized egg
- Human Chorionic Gonadotropin (HCG) secreted by chorion. LIke LH, HCG maintains the corpus luteum in the ovary, which secretes progesterone to maintain the thick endometrium of the uterus - HCG is measured by the pregnancy test
- Inner cell mass becomes the embryonic disk that will go through gastrulation to become 3 primary germ cell layers of the embyo (endoderm, mesoderm, and ectoderm)
Ectoderm
(outer layer)
epidermis of skin, epithelial lining of oral cavity and rectum, nervous system
Mesoderm
(middle layer)
skeleton, muscular system, dermis of skin, cardiovascular system, urinary system, reproductive system, outer layers of respiratory system and digestive system
Endoderm
(inner layer)
epithelial lining of digestive tract and respiratory tract; associated glands of these sytems, epithelial lining of urinary bladder
Embryonic Development: Week 3
Nervous system begins to develop from ectoderm - is first system to be seen
The posterior neural tube will become the spinal cord and brain
Development of the hear begins from mesoderm
Embryonic Development: Weeks 4 & 5
4th week: embryo is appx 1/16 inch long. Chorionic villi and umbilical cord form. Limb buds form (later develop into legs and arms)
5th week: head enlarges. Eyes, ears and nose become prominent