16. Odontogenic cyst Flashcards
Definition of cyst?
A cyst is a pathological cavity filled by fluid or semi-fluid contents, not created by accumulation of pus.
What are the 3 types of epithelial residues?
Glands of Serres- ex dental lamina
Reduced enamel epithelium- ex enamel organ
Rests of Malassez- ex root sheath of Hertwig
What can cysts be classified into?
Developmental
Inflammatory, eg. radicular cyst
What is the order of incidence of cysts?
Radicular
Dentigerous
Keratocyst
Paradental cyst
Gingival, lateral periodontal
What are the characteristics of a radicular inflammatory cyst?
Always associated with non-vital tooth or canal
Apical, lateral and residual
Rare in decidous dentition
Causes bone expansion- growth 5mm a year
Frequently no symptoms
What is the radiology of radicular cyst?
Radiolucency with radiopaque margin
What is the theory of formation of radicular cyst from pulp necrosis?
Pulp necrosis
Periapical inflammation- periapical granuloma
Cytokines and growth factors
Proliferation of rests of Malassez
Cyst formation
What are the 3 theories of cyst formation for radicular cyst?
- Death and degeneration of epithelial cells in centre of mass
- Liquefaction necrosis and degeneration of granulation tissue in centre, and lining by epithelial rests
- Lining of abscess by epithelial rests
How do you get enlargement of a radicular cyst?
Increased hydrostatic pressure from hypertonic contents and semi-permeable lining induces further enlargement.
What are the 3 things you get during enlargement of a radicular cyst?
- Silent phase
- Bony expansion
- Egg shell crackling
Osteoclastic activity- PGF2 PGE2 and PGI
Proteolytic enzymes- capsule fibroblasts
What is the lining of a radicular cyst?
Fully or partially lined by non-keratinised squamous epithelium
40% mucous cell metaplasia
10% Rushton bodies
What is the capsule of radicular cyst?
Chronically inflamed fibrous tissue
Variable vascularity
Haemosiderin
Cholesterol crystals
Foreign body giant cells
What is the contents of the radicular cyst?
HYPERTONIC WATERY TO SEMI-SOLID
Water and electrolytes
Serums proteins
Cholesterol crystals
Breakdown products
What are cholesterol clefts?
During expansion of the cyst, you get haemorrhage into the walls of the cyst. Main Blood breakdown product is cholesterol. During processing, they dissolve out but you will get empty stick like clefts which are surrounded by macrophages and giant cells.
What can be used to stain haemosiderin?
Berlin blue- stains blue