16. Odontogenic cyst Flashcards

1
Q

Definition of cyst?

A

A cyst is a pathological cavity filled by fluid or semi-fluid contents, not created by accumulation of pus.

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2
Q

What are the 3 types of epithelial residues?

A

Glands of Serres- ex dental lamina
Reduced enamel epithelium- ex enamel organ
Rests of Malassez- ex root sheath of Hertwig

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3
Q

What can cysts be classified into?

A

Developmental
Inflammatory, eg. radicular cyst

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4
Q

What is the order of incidence of cysts?

A

Radicular
Dentigerous
Keratocyst
Paradental cyst
Gingival, lateral periodontal

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5
Q

What are the characteristics of a radicular inflammatory cyst?

A

Always associated with non-vital tooth or canal
Apical, lateral and residual
Rare in decidous dentition
Causes bone expansion- growth 5mm a year
Frequently no symptoms

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6
Q

What is the radiology of radicular cyst?

A

Radiolucency with radiopaque margin

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7
Q

What is the theory of formation of radicular cyst from pulp necrosis?

A

Pulp necrosis
Periapical inflammation- periapical granuloma
Cytokines and growth factors
Proliferation of rests of Malassez
Cyst formation

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8
Q

What are the 3 theories of cyst formation for radicular cyst?

A
  1. Death and degeneration of epithelial cells in centre of mass
  2. Liquefaction necrosis and degeneration of granulation tissue in centre, and lining by epithelial rests
  3. Lining of abscess by epithelial rests
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9
Q

How do you get enlargement of a radicular cyst?

A

Increased hydrostatic pressure from hypertonic contents and semi-permeable lining induces further enlargement.

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10
Q

What are the 3 things you get during enlargement of a radicular cyst?

A
  1. Silent phase
  2. Bony expansion
  3. Egg shell crackling
    Osteoclastic activity- PGF2 PGE2 and PGI
    Proteolytic enzymes- capsule fibroblasts
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11
Q

What is the lining of a radicular cyst?

A

Fully or partially lined by non-keratinised squamous epithelium
40% mucous cell metaplasia
10% Rushton bodies

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12
Q

What is the capsule of radicular cyst?

A

Chronically inflamed fibrous tissue
Variable vascularity
Haemosiderin
Cholesterol crystals
Foreign body giant cells

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13
Q

What is the contents of the radicular cyst?

A

HYPERTONIC WATERY TO SEMI-SOLID
Water and electrolytes
Serums proteins
Cholesterol crystals
Breakdown products

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14
Q

What are cholesterol clefts?

A

During expansion of the cyst, you get haemorrhage into the walls of the cyst. Main Blood breakdown product is cholesterol. During processing, they dissolve out but you will get empty stick like clefts which are surrounded by macrophages and giant cells.

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15
Q

What can be used to stain haemosiderin?

A

Berlin blue- stains blue

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16
Q

What is a dentigerous cyst?

A

Associated with crown of unerupted tooth
Primary or secondary dentition
Central, circumferential or lateral

17
Q

Where are dentigerous cysts most often found?

A

Mandible males
Lower 8, upper 3, upper 8, lower 4 and 5

18
Q

What is the radiographic appearance of dentigerous cyst?

A

Unilocular radiolucent area

19
Q

What happens if tooth erupts with dentigerous cyst?

A

If the tooth partially erupts, the cyst attached to the tooth becomes infected and forms a paradental cyst.

20
Q

What is the pathogenesis of a dentigerous cyst?

A

Cyst formation between crown and reduced enamel epithelium or within the epithelium Proliferation of reduced enamel epithelium- mitotic activity.
Follicular compression- increased venous outflow
Associated with inflammation from non-vital deciduous tooth

21
Q

What is the lining of a dentigerous cyst?

A

Thin, regular 2-5 cells thick non-keratinised squamous or flattened epithelium
Some mucous cell dysplasia

22
Q

What is the capsule of a dentigerous cyst?

A

Fibrous tissue
No inflammation
Cholesterol crystals
Epithelial rests

23
Q

What is the link of dentigerous cyst to ameloblastoma?

A

If the epithelium proliferates into the lumen forming an ameloblast like plexus, it is called unicystic ameloblastoma.

24
Q

What is the contents of dentigerous cyst?

A

Hypertonic
Proteinaceous
Yellowish
Cholesterol crystals

25
Q

What is a keratocyst?

A

Most common mandible in 3rd molars
Often few symptoms
Grow very large- in anterior posterior direction

26
Q

Can keratocysts recur?

A

Friable capsule
Mitotic activity
Daughter cysts

27
Q

What are keratocysts derived from?

A

Basal mucosal cells
Dental lamina rests

28
Q

What is the 4 points of pathogenesis of keratocysts?

A
  1. Growth of epithelium- mitotic activity
  2. Bone resorbing factors unlikely
  3. Hydrostatic forces- as in radicular cysts
  4. Localised areas of squame deposition, thus increasing pressure
29
Q

What is the lining of keratocyst?

A

Thin, regular 5-10 cells keratinised epithelium- usually parak but can be orthok
Basal cells- palisading columnar appearance
Suprabasal cells- abrupt transition to keratin forming cells
Lumen- wavy appearance
Mitotic activity
If inflammation, lining is of radicular cyst

30
Q

What is the capsule of keratocyst like?

A

Thin, free from inflammation
Satellite cyst
Epithelial rest

31
Q

What is the contents of keratocyst like?

A

Thick, white-grey cheesy material- keratin debris

32
Q

What is daughter cysts?

A

Groups of epithelial cells can break off from basement membrane and form cysts in the wall of cyst. When they start producing keratin, and enlarge they are satellite cysts.

33
Q

What is a gingival cyst?

A

Epstein pearls
Bohn’s nodules
Remnants of dental lamina proliferate to form small keratinising cysts

34
Q

What is a lateral periodontal cyst?

A

Associated with a vital tooth- canine premolar
Thin-non keratinised lining with epithelial plaques
Perhaps a dentigerous cyst that got displaced during eruption.

35
Q

What is a botryoid cyst?

A

Uncommon multiocular
Thin non-keratinised lining with epithelial plaques
Vital tooth- canine and premolar
Can recur

36
Q

What is a glandular odontogenic cyst?

A

Columnar or cuboidal epithelium
Anterior mandible multiocular
Occasional mucous cells
Crypt like cyst like spaces
It is locally invasive