15_HST110 Introduction to Renal Disease I - AKI 2017 Flashcards
What is definition of acute kidney injury (AKI)?
Sudden, often temporary, loss in kidney function (hours to days). An abrupt decrease in renal function
What is the definition of chronic kidney disease (CKD)?
Structural or functional kidney abnormalities with or without decreased GFR for > 3 months
What is the definition of end stage renal disease (ESRD)?
Total and permanent kidney failure
AKI encompasses both (X) injury to the kidney and acute (Y). Etiology of AKI can be from within the kidney or from external stresses to the kidney
X = direct Y = impairment of function
AKI can be defined as any of the following:
Increase in Cr by ≥ (X) mg/dL within 48 hours
Increase in Cr by ≥ 1.5 times the baseline within the prior (Y) days
Urine volume < (Z) mL/kg/hour for 6 hours
X = 0.3 Y = 7 Z = 0.5
What percent of hospital admissions are due to AKI?
5-13%
What percent of ICU patients have AKI?
1-25%
What is the mortality of AKI in ICU patients (in %)?
15-60%
Recovery potential: Animal studies show permanent damage following experimentally-induced AKI, including what 2 conditions?
tubulointerstitial fibrosis
damage to microvasculature
Multiple human studies show an increased risk of (X) and (Z) even after recovery from AKI
X = CKD Y = ESRD
Define Azotemia
Abnormally high levels of nitrogen-containing compounds (e.g., urea, creatinine) in the blood
Define Oliguria
Low urine output
< 400 mL/day but >100 mL/day
Also defined as < 0.5 mL/kg/hour in adults
Define Anuria
Absence of urine
<100 mL/day
What are the 3 causes of AKI, based on location in the urinary system?
1) Prerenal (“before the kidney”)
2) Intrinsic Renal (“inside the kidney”)
3) Postrenal (“After the kidney”)
Postrenal AKI is typically caused by an (X) to urinary flow, occuring at any level of the urinary tract (kidney, ureters, bladder, or urethra)
X = obstruction
Why is all AKI considered postrenal until proven otherwise?
Early diagnosis and prompt correction of obstruction can result in minimal permanent kidney damage
Uncorrected obstruction can lead to irreversible renal failure
~10% of AKI is postrenal. Not most common, but direct intervention is possible so you want to be able to rule it out early on
Name 3 causes of kidney-localized postrenal AKI
Stones
Cancer
Sloughed papilla
Name 8 causes of ureter-localized postrenal AKI
Stones Cancer Sloughed papilla Extrinsic tumors Retroperitoneal fibrosis Infection Blood clot Trauma
Name 4 causes of bladder-localized postrenal AKI
Cancer
Blood clot
Edema/inflammation
Posterior urethral valves
Name 3 causes of urethra-localized postrenal AKI
Prostate enlargement
Stones
Strictures
How does postrenal AKI cause reduction in GFR? Use a formulaic argument
GFR decreases as a result of an increase in P_BS
GFR = Kf * {P_GC - (P_BS + (PI)_GC)]
Obstruction to urinary flow increases tubular pressure throughout the kidney
Increase in tubular pressure is transmitted back to the Bowman’s space and increases the hydrostatic pressure of Bowman’s space
Therefore, the forces favoring filtration will be decreased, and GFR will fall
What abnormal anatomical features are common in a postrenal urinary obstruction?
Distended structures (renal calyces, renal pelvis), stones or other obstruction present, blocked ureter
Under ultrasound, an obstruction results in what condition or appearance in the kidney, characterized by increased water retention?
Hydronephrosis. Dark regions were water is accumulating are evident. Thinning of the cortex is also seen
Under CT, hydronephrosis appears as a (X) mass
X = bulbous, distended
Name 3 treatment options for postrenal AKI in order of increasing severity and ascending location of obstruction
1) Urethra level: Foley catheter
2) Ureter level: Ureteral stent
3) Kidney level (complete bypass): Percutaneous nephrostomy tubes
Prerenal AKI is instigated by a decrease in renal perfucion. Name 2 conditions this can result from
Decreased ECV
Hypotension
Why does prerenal AKI not represent true “kidney injury?”
No intrinsic abnormality to the renal parenchyma is seen
How can prerenal AKI be corrected?
With restoration of volume and circulatory deficits
Name 5 causes of prerenal AKI due to ECV depletion (with DECREASED ECF)
Blood loss GI losses Renal losses Skin losses Third spacing
Name 3 causes of prerenal AKI due to ECV depletion (with INCREASED ECF)
CHF
Cirrhosis
Nephrotic syndrom
Stenosis of what blood vessel can cause prerenal AKI?
Renal artery
Name 6 drugs that can cause prerenal AKI
NSAIDs ACE inhibitors ARBs Cyclosporine Tacrolimus IV contrast
How does prerenal AKI cause reduction in GFR? Use a formulaic argument
GFR decreases as a result of an decrease in P_GC
GFR = Kf * {P_GC - (P_BS + (PI)_GC)]
Significant reduction in renal perfusion results in a decrease in capillary hydrostatic pressure
What 3 drugs can cause direct afferent vasoconstriction resulting in prerenal AKI?
Cyclosporine
Tacrolimus
IV contrast
NSAIDs inhibit afferent vasodilation, inhibiting the autoregulatory role of (X), leading to prerenal AKI
X = prostaglandins
ACE inhibitors and ARBs block the efferent vasoconstrictive effects of (X), leading to prerenal AKI
X = angiotensin II
Intrinsic Renal AKI can accur at what 4 levels?
Glomerular
Tubular
Interstitial
Vascular
Name 1 example of intrinsic renal AKI at each of its 4 levels
Glomerular: Acute glomerulonephritis
Interstitial: Acute interstitial nephritis
Tubular: Acute tubular necrosis
Vascular: Vasculitis