157b - Liver Tumors Flashcards
What is the #1 risk factor for hepatocellular carcinoma worldwide?
HBV
- Usually develops in a background of cirrhosis
- However, HBV can lead to HCC, even without cirrhosis
What is the major histologic finding of a hepatocellular adenoma?
No portal tract/bile duct
What are the risk factors for cholangiocarcinoma?
Anything that causes chronic inflammation in the biliary tree
- Parasites
- PSC
- Inflammatory bowel disease (usually UC)
What kind of liver tumor would have:
Glands with dirty necrosis in the glandular spaces
Metastatic colon cancer
- Usually multiple tumors
- Background liver is not cirrhotic
Which liver tumor is associated with frequent activation of WNT signaling?
Which gene is usually mutated?
Hepatoblastoma
(most common liver tumor of childhood; presents <3 y/o)
Mutation in the APC gene (familial adenosis polyposis)
What is the most common primary hepatic malignancy of adults?
Hepatocellular carcinoma
What is the most common benign neoplasm of the liver?
How should it be managed?
Hemangioma
If asymtomatic, can just be monitored; no risk of malignant transformation
What are the risk factors for hepatocellular adenoma?
Contraceptive pills
Steroids/hormones for body building
What is the most common liver neoplasm?
Metastatic from another site
Most commonly colon, lung, or breast
(But HCC is the most common primary liver tumor)
What kind of liver tumor has:
Fibrotic stroma with malignant-appearing ducts
Cholangiocarcinoma
What is the most common liver tumor of early childhood?
How should it be managed?
Hepatoblastoma
Resection + chemotherapy
(these are malignant)
Is a hepatocellular adenoma benign or malignant?
How should it be managed?
Benign
Should be resected anyway -
Risk of growth, bleeding, malignant transformation
