15.2 Flashcards
1
Q
Porto-oncogene
A
Normal gene that promotes growth and mitosis of the cell. It doesn’t become an oncogene until it becomes mutated
2
Q
Oncogene
A
A Proto-oncogene that has been mutated to increase the activity of its product.
3
Q
Tumor suppressor genes
A
Genes that prevent uncontrolled growth or divisions. Example: Rb protein
4
Q
What genes involved in cancer formation are dominant? And recessive?
A
Ras oncogene is dominant - only 1 mutation causes cancer. P53 is recessive due to both copies of the gene needing to be mutated to cause cancer
5
Q
PTEN
A
Phosphatase and tensin homology deleted on the chromosome Ten.
6
Q
Why is p53 mutated in most cancer cells?
A
Normally it suppresses cell growth, without it the cell divides non-stop
