14. Skin Cancer Flashcards
Name 2 genetic factors that predispose to skin cancer
Gorlin’s syndrome
Xeroderma pigmentosa mutation
Recall 2 viral infections that may cause skin cancer and the type of skin cancer they are associated with
HHV8 - Kaposi’s sarcoma
HPV - SCC
In which population is malignant melanoma most common?
White - by far
What is the most common form of skin cancer?
Basal cell carcinoma
Which forms of skin cancer are keratinocyte-derived?
Basal cell carcinoma
Squamous cell carcinoma
From what sort of cell is malignant melanoma derived?
Melanocytes
What is the most common site of basal cell carcinoma?
Eyelids
Compare the risk of metastasis in skin carcinomas?
Basal = does not metastasize Squamous = risk of metastasis
What is the proper name for “melanoma in situ”
Lentigo maligna
What is a melanoma in situ?
Melanoma that is confined to epidermis with no risk of metastasis
Describe the appearance of a lentigo maligna
Brown, irregular shape, flat
Recall the 3 MAIN types of melanoma
Lentigo maligna
Superficial spreading malignant melanoma
Nodular malignant melanoma
Describe and differentiate superficial spreading and nodular melanoma
Superficial spreading = lateral proliferation and invasion of BM
Nodular = vertical proliferation with no previous horizontal growth
What sort of melanoma is found on the palms of the hands and soles of the feet?
Acral lentiginous melanoma
What sort of skin cancer did tree-man have?
Epidermodysplasia verruciformis
