13 - Simple Cortical Circuits Flashcards
What are two model synaptic circuits?
- Glutamate receptor responses
- GABA receptor responses
What are two neuronal model circuits?
- Pyramidal cells
- Interneurons
Two types of neurons used in simple cortical circuits
- Pyramidal cell
- Glutamatergic - Interneurons
- GABAergic
4 connection types in simple cortical circuits
- Excitatory
- feedforward
- feedback
- Inhibitory
- Feedforward
- Feedback
- Somatic
- Dendritic
____ receptor is a glutamate-operated LGIC (made from GluR1-4) with a linear I-V relationship and an Erev of ~0mV
Charge carries: Na+, some K+ (Ca++ only in receptors missing GluR2)
*AMPA *receptor is a glutamate-operated LGIC (made from GluR1-4) with a linear I-V relationship and an Erev of ~0mV
Charge carries: Na+, some K+ (Ca++ only in receptors missing GluR2)
AMPA receptor is a ____ (made from ____) with a ____ I-V relationship and an Erev of ____
Charge carries: ______ , some (______ only in receptors missing ___)
AMPA receptor is a glutamate-operated LGIC (made from GluR1-4) with a linear I-V relationship and an Erev of ~0mV
Charge carries: Na+, some K+ (Ca++ only in receptors missing GluR2)
NMDA receptor is a: ____ (made from ____)
I-V relationship: _____
Erev = ____
Charge carriers: ____, _____, ____
NMDA receptor is a: glutamate operated LGIC (made from NR1 + NR2A-D)
I-V relationship: non-linear (caused by Mg2+ block at neg voltages)
Erev = ~0mV
Charge carriers: Na+, Ca++, K+
____ receptor is a: glutamate operated LGIC (made from NR1 + NR2A-D)
I-V relationship: non-linear (caused by Mg2+ block at neg voltages)
Erev = ~0mV
Charge carriers: Na+, Ca++, K+
*NMDA *receptor is a: glutamate operated LGIC (made from NR1 + NR2A-D)
I-V relationship: non-linear (caused by Mg2+ block at neg voltages)
Erev = ~0mV
Charge carriers: Na+, Ca++, K+
Why is the I-V relationship of NMDA nonlinear?
Because there is a Mg++ block of the channel at negative voltages
GABAA - ____
Charge carriers: ____
Erev = ____
GABAA - GABA-operated LGIC
Charge carriers: *Cl-, HCO3-, *
Erev = -65mV
____ - GABA-operated LGIC
Charge carriers: Cl-, HCO3-,
Erev = -65mV
GABAA - GABA-operated LGIC
Charge carriers: Cl-, HCO3-,
Erev = -65mV
____ - GABA-activated GPCR
Activates: GIRK (inward rectifier)
Erev = -100mV
GABAB - GABA-activated GPCR
Activates: GIRK (inward rectifier)
Erev = -100mV
GABAB - ____
Activates: ____
Erev = ____
GABAB - GABA-activated GPCR
Activates: GIRK (inward rectifier)
Erev = -100mV
Pyramidal cell:
- ____ releasing
- Structure?
- Receptors?
Pyramidal cell:
- Glutamate releasing
- Structure?
- Large apical dendrite
- Large cell body (soma)
- Axon
- Receptors?
- NMDA, AMPA
- GABAA
- GABAB
Interneuron:
- ____ releasing
- Driven by ____
Interneuron:
- GABA releasing
- Driven by AMPA excitation
