13 - Drugs used in the treatment of angina pectoris Flashcards
1
Q
AMYL NITRITE class similar drugs moa uses se
A
- ultrashort acting nitrate
- none
- releases NO, increases cGMP, relaxes smooth muscle, especially vascular
- cyanide poisoning
- reflex tachycardia, orthostatic hypotension, headache, methemoglobinemia
2
Q
Monday disease
A
due to occupational exposure to nitrates
- alternating development of tolerance (during the work week) and loss of tolerance (over the weekend) every Monday
3
Q
NITROGLYCERINE class similar drugs moa uses se
A
- short-acting nitrate
- isosorbide dinitrate, isosorbide mononitrate
- releases NO, increases cGMP, relaxes smooth muscle, especially vascular
- angina, acs
- reflex tachycardia, orthostatic hypotension, headache, tolerance (transdermal)
dangerous hypotension with PDE inhibitors
4
Q
Nitrate induced headache
A
due to meningeal blood vessel vasodilation
5
Q
NIFEDIPINE class similar drugs moa uses se
A
- dhp ca ch blocker
- amlodipine, felodipine, nicardipine, nisoldipine, clevidipine, isradipine
- block voltage gated L type ca ch (vascular>cardiac)
- angina, hypertension
- constipation, pretibial edema, nausea, flushing, dizzines, gingival hyperplasia
6
Q
VERAPAMIL class similar drugs moa uses se
A
- non dhp ca ch blocker
- block voltage gated L type ca ch cardiac>vascular
- angina, hypertension, SVT, migraine
- constipation, pretibial edema, nausea, flushing, dizziness, gingival hyperplasia, heart failure, av block, sinus node depression
7
Q
DILTIAZEM class similar drugs moa uses se
A
- non dhp ca ch blocker
- block voltage gated L type ca ch cardiac>vascular
- angina, hypertension, svt, vasospasm, raynaud’s phenomenon, DOC FOR PRINZMETAL’S ANGINA
- constipation, pretibial edema, nausea, flushing, dizziness, heart failure, av block, sinus node depression
no gingival hyperplasia
8
Q
why is ca dependent neurotransmission or hormone release not affected by CCBS?
A
CCBS block L-type ca ch
- other functions use N, P, R types
9
Q
What drugs can cause gingival hyperplasia?
A
nifedipine
cyclosporine
phenytoin
verapamil
