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Pharma > 09 - Adrenergic Pharmacology > Flashcards

09 - Adrenergic Pharmacology Flashcards

1
Q

Norepinephrine

A

primary transmitter at the sympathetic postganglionic neuron effector cell synapses in most tissues

exceptions:

  • eccrine sweat glands
  • vasodilator sympathetic fibers in skeletal muscle
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2
Q

Dopamine/Norepinephrine on renal blood vessels

A

dopamine vasodilates renal blood vessels

norepinephrine vasoconstricts

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3
Q

Tyrosine is hydroxylated by tyrosine hydroxylase to

A

DOPA

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4
Q

Tyrosine hydroxylase is inhibited by

A

metyrosine

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5
Q

DOPA is decarboxylated to

A

dopamine

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6
Q

dopamine is hydroxylated to

A

norepinephrine

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7
Q

NE and dopamine are transported into vesicles

inactivated by:

A

monoamine oxidase in the cytoplasm

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8
Q

increase stores of NE and dopamine

A

MAOIs

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9
Q

vesicular transport inhibted by

A

reserpine

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10
Q

entry of calcium triggers interaction among

A

SNARE proteins (VAMPs and SNAPs)

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11
Q

What are SNARE proteins

A

“SNAP (Soluble NSF Attachment Protein) REceptor”

The primary role of SNARE proteins is to mediate vesicle fusion, that is, the fusion of vesicles with their target membrane bound compartments (such as a lysosome). The best studied SNAREs are those that mediate docking of synaptic vesicles with the presynaptic membrane in neurons. These SNAREs are the targets of the bacterial neurotoxins responsible for botulism and tetanus.

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12
Q

entry of calcium inhibited by

promoted by

A

guanethidine

amphetamines and tyramine

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13
Q

diffusion and reupate via NET and DAT in synaptic cleft

inhibited by

A

cocaine and TCAs

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14
Q

metabolized by MAO and COMT into

inhibited by

A

metanephrines and VMA

MAOIs and COMT inhibitors (duh)

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15
Q

Site of autonomic drug action:

synthesis cholinergic and adrenergic inhibitors

A

hemicholinium

metyrosine

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16
Q

Site of autonomic drug action:

storage cholinergic and adrenergic inhibitors

A

vesamicol

reserpine

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17
Q

Site of autonomic drug action:

release cholinergic and adrenergic inhibitors

A

botulinium

guanethedine

18
Q

Site of autonomic drug action:

termination metabolism cholinergic and adrenergic inhibitors

A

neostigmine

MAOIs, COMTIs

19
Q

Site of autonomic drug action:

termination reuptake cholinergic and adrenergic inhibitors

A

none

cocaine, TCAs

20
Q

drug effects on adrenergic transmission

A

used in treatment of several diseases (pheochromocytoma, hypertension)
block sympathetic but NOT parasympathetic functions

other drugs promote catecholamine release - predictably cause sympathomimetics effects

21
Q

a1 adrenergic effects

- most vascular smooth muscle

A

contracts (increased vascular resistance)

22
Q

a1 adrenergic effects

- pupillary dilator muscle

A

contracts (mydriasis)

23
Q

a1 adrenergic effects

- pilomotor smooth muscle

A

contracts (erects hair)

24
Q

a1 adrenergic effects

- liver (in some species, eg, rat)

A

stimulates glycogenolysis

25
Q

a2 adrenergic effects

- adrenergic and cholinergic nerve terminals

A

inhibits transmitter release

26
Q

a2 adrenergic effects

- platelets

A

stimulates aggregation

27
Q

a2 adrenergic effects

- some vascular smooth muscle

A

contracts

28
Q

a2 adrenergic effects

- fat cells

A

inhibits lypolysis

29
Q

a2 adrenergic effects

- pancreatic B cells

A

inhibits insulin release

30
Q

B1 adrenergic effects

- heart

A

stimulates rate and force

31
Q

B1 adrenergic effects

- juxtaglomerular cells of kidney

A

stimulates renin release

32
Q

B2 adrenergic effects

- airways, uterine, and vascular smooth muscle

A

relaxes

33
Q

B2 adrenergic effects

- liver (human)

A

stimulates glycogenolysis

34
Q

B2 adrenergic effects

- pancreatic B cells

A

stimulates insulin release

35
Q

B2 adrenergic effects

- somatic motor neuron terminals (voluntary muscle)

A

causes tremor

36
Q

B2 adrenergic effects

- heart

A

stimulates rate and force

37
Q

B3 adrenergic effects

- fat cells

A

stimulates lipolysis

38
Q

dopamine1 (d1) adrenergic effects

- renal and other splanchnic blood vessels

A

dilates (decrease resistance)

39
Q

d2 adrenergic effects

- nerve terminals

A

inhibits adenylyl cyclase

40
Q

beta receptors mnemonic

A

1 heart, 2 lungs

b1 heart
b2 lungs

Pharma (7 decks)

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