12.3 cell cycle clock: cyclins and cyclin dependent kinases Flashcards
1
Q
2 most likely types of regulatory molecules
A
protein kinases and
cyclins
2
Q
protein kinases
A
enzymes that activate/inactivate other proteins by phosphorylating them
3
Q
where do protein kinases work
A
g1
g2 checkpoints
4
Q
cyclins
A
activate kinases
-cyclically fluctuating concentration in the cell
5
Q
cyclin dependent kinases
A
Cdks
kinases dependent on cyclin to be activated
6
Q
MPF
A
cdk in frog eggs
-show how cyclin affects kinase
G2-> M
when cyclin accumulates in G2 phase, it activates kinase which phosphorylates proteins to initiate Mitosis
-then MPF destroys cyclin itself
